About: Low-density lipoprotein is a potential predictor of poor prognosis in patients with coronavirus disease 2019

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About: Low-density lipoprotein is a potential predictor of poor prognosis in patients with coronavirus disease 2019 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Low-density lipoprotein is a potential predictor of poor prognosis in patients with coronavirus disease 2019
Creator	Wang, Hui Zhang, Yongxi Ye, Guangming Cao, Xiaoling Tan, Wenbin Fan, Junli Xu, Xianqun
Source	Elsevier; Medline; PMC; WHO
abstract	Abstract Background The pandemic of coronavirus disease 2019 (COVID-19) has become a global threat to public health. The lipid pathophysiology in COVID-19 is unknown. Methods In this retrospective longitudinal study, we monitored the serum lipids in 17 surviving and 4 non-surviving COVID-19 cases prior to their viral infections and duration the entire disease courses. Results In surviving cases, the low-density lipoprotein (LDL) levels decreased significantly on admission as compared with the levels before infection; the LDL levels remained constantly low during the disease progression and resumed to the original levels when patients recovered (pre-infection: 3.5 (3.0–4.4); on admission: 2.8 (2.3–3.1), p < .01; progression: 2.5 (2.3–3.0); discharge: 3.6 (2.7–4.1); median (IQR), in mmol/L). In non-surviving patients, LDL levels showed an irreversible and continuous decrease until death (1.1 (0.9–1.2), p = .02 versus the levels on admission). The ratio changes of LDL levels inversely correlated with ratio changes of high-sensitivity C-reactive protein levels. Logistic regression analysis showed increasing odds of lowered LDL levels associated with disease progression (odds ratio: 4.48, 95% IC: 1.55–12.92, p = .006) and in-hospital death (odds ratio: 21.72, 95% IC: 1.40–337.54, p = .028). Conclusions LDL levels inversely correlated to disease severities, which could be a predictor for disease progress and poor prognosis.
has issue date	2020-04-19(xsd:dateTime)
bibo:doi	10.1016/j.metabol.2020.154243
bibo:pmid	32320740
has license	els-covid
sha1sum (hex)	9f27ec4714710fa2e9add31ee5668ebb98fa1e46
schema:url	https://doi.org/10.1016/j.metabol.2020.154243
resource representing a document's title	Low-density lipoprotein is a potential predictor of poor prognosis in patients with coronavirus disease 2019
has PubMed Central identifier	PMC7166305
has PubMed identifier	32320740
schema:publication	Metabolism
resource representing a document's body	covid:9f27ec4714710fa2e9add31ee5668ebb98fa1e46#body_text
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