About: CD8+ T cell cross-reactivity against SARS-CoV-2 conferred by other coronavirus strains and influenza virus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	CD8+ T cell cross-reactivity against SARS-CoV-2 conferred by other coronavirus strains and influenza virus
Creator	Simmons, Alison Koohy, Hashem Buckley, Paul Lee, Chloe Napolitani, Giorgio Ogg, Graham Pereira Pinho, Woodhouse, Isaac
Source	BioRxiv
abstract	While individuals infected with coronavirus disease 2019 (COVID-19) manifested a broad range in susceptibility and severity to the disease, the pre-existing immune memory of related pathogens can influence the disease outcome. Here, we investigated the potential extent of T cell cross-reactivity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that can be conferred by other coronaviruses and influenza virus, and generated a map of public and private predicted CD8+ T cell epitopes between coronaviruses. Moreover, to assess the potential risk of self-reactivity and/or diminished T cell response for peptides identical or highly similar to the host, we identified predicted epitopes with high sequence similarity with human proteome. Lastly, we compared predicted epitopes from coronaviruses with epitopes from influenza virus deposited in IEDB to support vaccine development against different virus strains. We believe the comprehensive in silico profile of private and public predicted epitopes across coronaviruses and influenza viruses will facilitate design of vaccines capable of protecting against various viral infections.
has issue date	2020-05-20(xsd:dateTime)
bibo:doi	10.1101/2020.05.20.107292
has license	biorxiv
sha1sum (hex)	9ef9eff79c7d4b6f89ffed2c1c7b28350dc36c34
schema:url	https://doi.org/10.1101/2020.05.20.107292
resource representing a document's title	CD8+ T cell cross-reactivity against SARS-CoV-2 conferred by other coronavirus strains and influenza virus
schema:publication	bioRxiv
resource representing a document's body	covid:9ef9eff79c7d4b6f89ffed2c1c7b28350dc36c34#body_text
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