About: The UPR sensor IRE1α and the adenovirus E3-19K glycoprotein sustain persistent and lytic infections

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About: The UPR sensor IRE1α and the adenovirus E3-19K glycoprotein sustain persistent and lytic infections Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The UPR sensor IRE1α and the adenovirus E3-19K glycoprotein sustain persistent and lytic infections
Creator	Greber, F Hemmi, Silvio Hearing, Patrick Suomalainen, Maarit Burgert, Hans-Gerhard Hosie, Louise Jasiqi, Yllza Prasad, Vibhu Urs, &
Source	Medline; PMC
abstract	Persistent viruses cause chronic disease, and threaten the lives of immunosuppressed individuals. Here, we elucidate a mechanism supporting the persistence of human adenovirus (AdV), a virus that can kill immunosuppressed patients. Cell biological analyses, genetics and chemical interference demonstrate that one of five AdV membrane proteins, the E3-19K glycoprotein specifically triggers the unfolded protein response (UPR) sensor IRE1α in the endoplasmic reticulum (ER), but not other UPR sensors, such as protein kinase R-like ER kinase (PERK) and activating transcription factor 6 (ATF6). The E3-19K lumenal domain activates the IRE1α nuclease, which initiates mRNA splicing of X-box binding protein-1 (XBP1). XBP1s binds to the viral E1A-enhancer/promoter sequence, and boosts E1A transcription, E3-19K levels and lytic infection. Inhibition of IRE1α nuclease interrupts the five components feedforward loop, E1A, E3-19K, IRE1α, XBP1s, E1A enhancer/promoter. This loop sustains persistent infection in the presence of the immune activator interferon, and lytic infection in the absence of interferon.
has issue date	2020-04-24(xsd:dateTime)
bibo:doi	10.1038/s41467-020-15844-2
bibo:pmid	32332742
has license	cc-by
sha1sum (hex)	9ef89ffafd3be24d57aac0ab00cbf6f4c6c43a73
schema:url	https://doi.org/10.1038/s41467-020-15844-2
resource representing a document's title	The UPR sensor IRE1α and the adenovirus E3-19K glycoprotein sustain persistent and lytic infections
has PubMed Central identifier	PMC7181865
has PubMed identifier	32332742
schema:publication	Nat Commun
resource representing a document's body	covid:9ef89ffafd3be24d57aac0ab00cbf6f4c6c43a73#body_text
is schema:about of	named entity 'protein kinase' named entity 'chronic disease' named entity 'membrane proteins' named entity 'unfolded protein response' named entity 'persistent' named entity 'individuals' named entity 'levels' named entity 'UPR' named entity 'viruses' named entity 'kill' named entity 'activating transcription factor 6' named entity 'This' named entity 'AdV' named entity 'E1A' named entity 'immunosuppressed' named entity 'XBP1' named entity 'Cell biological' named entity 'E1A' named entity 'UPR' named entity 'adenovirus' named entity 'interferon' named entity 'IRE1α' named entity 'AdV' named entity 'glycoprotein' named entity 'E1A' named entity 'ATF6' named entity 'protein kinase' named entity 'IRE1α' named entity 'kinase' named entity 'promoter sequence' named entity 'mRNA splicing' named entity 'virus' named entity 'infection' named entity 'enhancer' named entity 'lytic' named entity 'IRE1α' named entity 'genetics' named entity 'chronic disease' named entity 'enhancer' named entity 'lives' named entity 'domain' named entity 'promoter' named entity 'AdV' named entity 'transcription' named entity 'PERK' named entity 'lytic infection' named entity 'lytic infection' named entity 'endoplasmic reticulum' named entity 'IRE1α' named entity 'immunosuppressed' named entity 'activating transcription factor 6' named entity 'E1A' named entity 'R-like' named entity 'IRE1α' named entity 'viruses' named entity 'nuclease' named entity 'interferon' named entity 'adenovirus' named entity 'glycoprotein' covid:arg/9ef89ffafd3be24d57aac0ab00cbf6f4c6c43a73 named entity 'UPR' named entity 'nuclease' named entity 'binding protein' named entity 'lumenal' named entity 'membrane proteins' named entity 'unfolded protein response' named entity 'UPR' named entity 'binding' named entity 'nuclease' named entity 'persistence' named entity 'endoplasmic reticulum' named entity 'triggers' named entity 'sensors'

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