About: Cardiac Injury Patterns and Inpatient Outcomes Among Patients Admitted with COVID-19

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Cardiac Injury Patterns and Inpatient Outcomes Among Patients Admitted with COVID-19
Creator	Raad, Mohamad Chehab, Omar Cook, Bernard Dabbagh, Mohammed Dagher, Carina Gorgis, Sarah Jamoor, Khaled Parikh, Sachin Singh, Gurjit Yan, Jerry Hajj, Inaya Harn, Meredith Hussein, Hajj Mccord, James Phd, Hussein
topic	covid:9eceff65c43ed5e00a6933595808da730dc29077#this
source	Elsevier; Medline; PMC
abstract	Although certain risk factors have been associated with increased morbidity and mortality in patients admitted with Coronavirus Disease 2019 (COVID-19), the impact of cardiac injury and high-sensitivity troponin-I (hs-cTnI) concentrations are not well described. In this large retrospective longitudinal cohort study, we analyzed the cases of 1044 consecutively admitted patients with COVID-19 from March 9(th) until April 15(th). Cardiac injury was defined by a hs-cTnI concentration >99(th) percentile. Patient characteristics, laboratory data, and outcomes were described in patients with cardiac injury and different hs-cTnI cut-offs. The primary outcome was mortality, and the secondary outcomes were length of stay, need for intensive care unit care or mechanical ventilation, and their different composites. The final analyzed cohort included 1020 patients. The median age was 63 years, 50% of patients were female, and 40% were white. 390 (38%) patients had cardiac injury on presentation. These patients were older (median age 70 years), had a higher cardiovascular disease burden, in addition to higher serum concentrations of inflammatory markers. They also exhibited an increased risk for our primary and secondary outcomes, with the risk increasing with higher hs-cTnI concentrations. Peak hs-cTnI concentrations continued to be significantly associated with mortality after a multivariate regression controlling for comorbid conditions, inflammatory markers, acute kidney injury, and acute respiratory distress syndrome. Within the same multivariate regression model, presenting hs-cTnI concentrations were not significantly associated with outcomes, and undetectable hs-cTnI concentrations on presentation did not completely rule out the risk for mechanical ventilation or death. In conclusion, cardiac injury was common in patients admitted with COVID-19. The extent of cardiac injury and peak hs-cTnI concentrations were associated with worse outcomes.
has issue date	2020-07-24(xsd:dateTime)
bibo:doi	10.1016/j.amjcard.2020.07.040
bibo:pmid	32829913
has license	no-cc
sha1sum (hex)	9eceff65c43ed5e00a6933595808da730dc29077
schema:url	https://doi.org/10.1016/j.amjcard.2020.07.040
resource representing a document's title	Cardiac Injury Patterns and Inpatient Outcomes Among Patients Admitted with COVID-19
has PubMed Central identifier	PMC7378523
has PubMed identifier	32829913
schema:publication	Am J Cardiol
resource representing a document's body	covid:9eceff65c43ed5e00a6933595808da730dc29077#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/9eceff65c43ed5e00a6933595808da730dc29077
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