About: A novel programed frameshift expresses the POL3 gene of retrotransposon Ty3 of yeast: Frameshifting without tRNA slippage

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About: A novel programed frameshift expresses the POL3 gene of retrotransposon Ty3 of yeast: Frameshifting without tRNA slippage Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A novel programed frameshift expresses the POL3 gene of retrotransposon Ty3 of yeast: Frameshifting without tRNA slippage
Creator	Zhao, Hong Farabaugh, Philip Vimaiadithan, Arunachaiam
Source	Elsevier; Medline; PMC
abstract	Abstract Most retroviruses and retrotransposons express their pol gene as a translational fusion to the upstream gag gene, often involving translational frameshifting. We describe here an unusual translational frameshift event occurring between the GAG3 and POL3 genes of the retrotransposon Ty3 of yeast. A +1 frameshift occurs within the sequence GCG AGU U (shown as codons of GAG3), encoding alanine-valine ( GCG A GUU ). Unlike other programed translational frameshifts described, this event does not require tRNA slippage between cognate or near-cognate codons in the mRNA. Two features distal to the GCG codon stimulate frameshifting. The low availability of the tRNA specific for the “hungry” serine codon, AGU, induces a translational pause required for frameshifting. A sequence of 12 nt distal to the AGU codon (termed the Ty3. “context”) also stimulates the event.
has issue date	1993-07-16(xsd:dateTime)
bibo:doi	10.1016/0092-8674(93)90297-4
bibo:pmid	8267715
has license	els-covid
sha1sum (hex)	9ec5aad7475f2285421292fae94f8568f72971fe
schema:url	https://doi.org/10.1016/0092-8674%2893%2990297-4
resource representing a document's title	A novel programed frameshift expresses the POL3 gene of retrotransposon Ty3 of yeast: Frameshifting without tRNA slippage
has PubMed Central identifier	PMC7172889
has PubMed identifier	8267715
schema:publication	Cell
resource representing a document's body	covid:9ec5aad7475f2285421292fae94f8568f72971fe#body_text
is schema:about of	named entity 'Slippage' named entity 'tRNA' named entity 'B-galactosidase' named entity 'tRNA' named entity 'PCR primers' named entity 'N-terminal' named entity 'reading frames' named entity 'Edman degradation' named entity 'Engelberg' named entity 'phenotypic effect' named entity 'codon' named entity 'tRNA' named entity 'GCG' named entity 'ribosomes' named entity 'frameshift' named entity 'integrase' named entity 'gene' named entity 'frameshifting' named entity 'nucleotide' named entity 'plasmid' named entity 'Kalnik' named entity 'cognate' named entity 'frameshifting' named entity 'tRNA' named entity 'random error' named entity 'frameshift' named entity 'Frameshifting' named entity 'retrotransposons' named entity 'origin of replication' named entity 'ternary complex' named entity 'codon' named entity 'gene' named entity 'frameshifting' named entity 'RNA sequence' named entity 'ribosomal' named entity 'codons' named entity 'GUU' named entity 'tRNA' named entity 'tRNA' named entity 'base pairing' named entity 'codon' named entity 'PCR' named entity 'plasmids' named entity 'codon' named entity 'nucleotide' named entity 'nucleotide' named entity 'tRNAs' named entity 'PCR' named entity 'nucleotide' named entity 'codon' named entity 'EF-Tu' named entity 'Frameshifting' named entity 'ribosomal' named entity 'codon' named entity 'mRNA' named entity 'closely related' named entity 'frameshift' named entity 'double-stranded DNA' named entity 'frameshift' named entity 'frameshift' named entity 'three-dimensional structure' named entity 'Oligonucleotides' named entity 'frameshift' named entity 'gene' named entity 'codon' named entity 'mRNA' named entity 'codons' named entity 'GCG' named entity 'codons' named entity 'codons' named entity 'lacZ' named entity 'frameshifting' named entity 'Frameshifting' named entity 'initiation codon' named entity 'Oligonucleotides' named entity 'mRNA' named entity 'sense codon' named entity 'seryl' named entity 'retroviral'

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