About: Rodent animal models: from mild to advanced stages of diabetic nephropathy

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Rodent animal models: from mild to advanced stages of diabetic nephropathy
Creator	Kaur, Manpreet Bedi, Onkar Kumar, Puneet Reddy, • Sachdeva, Shilpi
Source	PMC
abstract	Diabetic nephropathy (DN) is a secondary complication of both type 1 and type 2 diabetes, resulting from uncontrolled high blood sugar. 30–40 % of diabetic patients develop DN associated with a poor life expectancy and end-stage renal disease, causing serious socioeconomic problems. Although an exact pathogenesis of DN is still unknown, several factors such as hyperglycemia, hyperlipidemia, hypertension and proteinuria may contribute to the progression of renal damage in diabetic nephropathy. DN is confirmed by measuring blood urea nitrogen, serum creatinine, creatinine clearance and proteinuria. Clinical studies show that intensive control of hyperglycemia and blood pressure could successfully reduce proteinuria, which is the main sign of glomerular lesions in DN, and improve the renal prognosis in patients with DN. Diabetic rodent models have traditionally been used for doing research on pathogenesis and developing novel therapeutic strategies, but have limitations for translational research. Diabetes in animal models such as rodents are induced either spontaneously or by using chemical, surgical, genetic, or other techniques and depicts many clinical features or related phenotypes of the disease. This review discusses the merits and demerits of the models, which are used for many reasons in the research of diabetes and diabetic complications.
has issue date	2014-08-23(xsd:dateTime)
bibo:doi	10.1007/s10787-014-0215-y
bibo:pmid	25149089
has license	no-cc
sha1sum (hex)	9ebbbd67f2bfcfb14687d613be823b1cfd1475c6
schema:url	https://doi.org/10.1007/s10787-014-0215-y
resource representing a document's title	Rodent animal models: from mild to advanced stages of diabetic nephropathy
has PubMed Central identifier	PMC7101706
has PubMed identifier	25149089
schema:publication	Inflammopharmacology
resource representing a document's body	covid:9ebbbd67f2bfcfb14687d613be823b1cfd1475c6#body_text
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