About: Genetic characterization of porcine epidemic diarrhea virus in Korea from 1998 to 2013

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About: Genetic characterization of porcine epidemic diarrhea virus in Korea from 1998 to 2013 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Genetic characterization of porcine epidemic diarrhea virus in Korea from 1998 to 2013
Creator	Oem, Jae-Ku Lee, Myoung-Heon Kim, Seong-Hee Lee, Kyoung-Ki Park, Choi-Kyu Kim, In-Joong Bang-Hun, • Jung, Jongsun Kim, Hyun-Il Kim, Yeon-Hee Lee, Jung-Min
Source	Medline; PMC
abstract	The number of porcine epidemic diarrhea (PED) cases has increased over the past 20 years in Korea, with a major outbreak in 2013. A total of 27 Korean strains from 1998 to 2013 were analyzed (excluding the noncoding regions) and divided into two groups for comparison of the spike (S), ORF3, envelope (E), membrane (M), and nucleocapsid (N) genes with those of reference strains, vaccine strains, and previously identified strains based on phylogenetic analysis. Analysis of the selection patterns of PEDV isolated in Korea indicated positive selection of nine nonsynonymous sites in the S and N proteins and negative selection at 97 sites for all of the proteins. Interestingly, eight nonsynonymous mutations in S showed no significant pattern change over the 15-year period, and one of eight mutation sites was found only in IC05TK, GN05DJ, and KNU0802 in the epidemic years 2005 and 2008. These eight mutations were also present during the epidemic years in China. Furthermore, of the signs of positive selection in the S protein, the conservative substitutions were more frequent than radical substitutions in PEDVs, suggesting that the evolution of Korean strains has been slow. Serological cross-reactivity was detected between three field PEDVs and two vaccine strains, with different serum neutralization titers. In conclusion, although Korean PEDVs have been evolving slowly, their diverse antigenicity and genetics imply that multilateral efforts to prevent future PED outbreaks are required. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00705-015-2353-y) contains supplementary material, which is available to authorized users.
has issue date	2015-02-10(xsd:dateTime)
bibo:doi	10.1007/s00705-015-2353-y
bibo:pmid	25666198
has license	no-cc
sha1sum (hex)	9ea5729a5e0502724c7dc225b50323a913a9dea0
schema:url	https://doi.org/10.1007/s00705-015-2353-y
resource representing a document's title	Genetic characterization of porcine epidemic diarrhea virus in Korea from 1998 to 2013
has PubMed Central identifier	PMC7086719
has PubMed identifier	25666198
schema:publication	Arch Virol
resource representing a document's body	covid:9ea5729a5e0502724c7dc225b50323a913a9dea0#body_text
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