About: The immune gene repertoire of an important viral reservoir, the Australian black flying fox

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The immune gene repertoire of an important viral reservoir, the Australian black flying fox Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The immune gene repertoire of an important viral reservoir, the Australian black flying fox
Creator	Wang, Lin-Fa Crameri, Gary Cowled, Chris Field, Hume Tachedjian, Mary Baker, Michelle Janardhana, Vijaya Ng, Justin Feng, Zhi-Ping Papenfuss, Anthony
source	Medline; PMC
abstract	BACKGROUND: Bats are the natural reservoir host for a range of emerging and re-emerging viruses, including SARS-like coronaviruses, Ebola viruses, henipaviruses and Rabies viruses. However, the mechanisms responsible for the control of viral replication in bats are not understood and there is little information available on any aspect of antiviral immunity in bats. Massively parallel sequencing of the bat transcriptome provides the opportunity for rapid gene discovery. Although the genomes of one megabat and one microbat have now been sequenced to low coverage, no transcriptomic datasets have been reported from any bat species. In this study, we describe the immune transcriptome of the Australian flying fox, Pteropus alecto, providing an important resource for identification of genes involved in a range of activities including antiviral immunity. RESULTS: Towards understanding the adaptations that have allowed bats to coexist with viruses, we have de novo assembled transcriptome sequence from immune tissues and stimulated cells from P. alecto. We identified about 18,600 genes involved in a broad range of activities with the most highly expressed genes involved in cell growth and maintenance, enzyme activity, cellular components and metabolism and energy pathways. 3.5% of the bat transcribed genes corresponded to immune genes and a total of about 500 immune genes were identified, providing an overview of both innate and adaptive immunity. A small proportion of transcripts found no match with annotated sequences in any of the public databases and may represent bat-specific transcripts. CONCLUSIONS: This study represents the first reported bat transcriptome dataset and provides a survey of expressed bat genes that complement existing bat genomic data. In addition, these data provide insight into genes relevant to the antiviral responses of bats, and form a basis for examining the roles of these molecules in immune response to viral infection.
has issue date	2012-06-20(xsd:dateTime)
bibo:doi	10.1186/1471-2164-13-261
bibo:pmid	22716473
has license	cc-by
sha1sum (hex)	9ea2edcf3b251f6a0bc4d4c36aefe9fa91655a70
schema:url	https://doi.org/10.1186/1471-2164-13-261
resource representing a document's title	The immune gene repertoire of an important viral reservoir, the Australian black flying fox
has PubMed Central identifier	PMC3436859
has PubMed identifier	22716473
schema:publication	BMC Genomics
resource representing a document's body	covid:9ea2edcf3b251f6a0bc4d4c36aefe9fa91655a70#body_text
is schema:about of	named entity 'viruses' named entity 'activities' named entity 'black flying fox' named entity 'species' named entity 'control' named entity 'Rabies' named entity 'Pteropus alecto' named entity 'natural reservoir host' named entity 'Rabies' named entity 'antiviral' named entity 'Ebola' named entity 'bat species' named entity 'transcriptome' named entity 'low coverage' named entity 'megabat' named entity 'viral reservoir' named entity 'discovery' named entity 'thymus' named entity 'RNA extraction' named entity 'Japanese encephalitis' named entity 'UniProt' named entity 'Illumina' named entity 'Mx1' named entity 'CD94' named entity 'CD1b' named entity 'bat' named entity 'PKR' named entity 'immune genes' named entity 'amino acid' named entity 'Mx1' named entity 'plasma membrane' named entity 'signalling pathways' named entity 'species rich' named entity 'Nycomed' named entity 'bat' named entity 'Mx proteins' named entity 'line of defence' named entity 'interferon' named entity 'P. alecto' named entity 'Australian bat lyssavirus' named entity 'pattern recognition receptors' named entity 'OAS1' named entity 'loci' named entity 'homologue' named entity 'spleen' named entity 'Gene Ontology' named entity 'BLASTX' named entity 'clade' named entity 'viral diseases' named entity 'OAS3' named entity 'protamine' named entity 'bat' named entity 'bat' named entity 'previously identified' named entity 'oases' named entity 'co-evolutionary' named entity 'CD94' named entity 'bat' named entity 'mammalian species' named entity 'bat' named entity 'Cysteine' named entity 'IL-10R2' named entity 'cathepsin' named entity 'immune cells' named entity 'Phylogenetic analysis' named entity 'heterodimer' named entity 'IFN' named entity 'locus' named entity 'thymus' named entity 'RIG-I' named entity 'streptomycin' named entity 'NOD-like receptor'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software