About: CLEC2 and CLEC5A: Pathogenic Host Factors in Acute Viral Infections

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About: CLEC2 and CLEC5A: Pathogenic Host Factors in Acute Viral Infections Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	CLEC2 and CLEC5A: Pathogenic Host Factors in Acute Viral Infections
Creator	Hsieh, Shie-Liang Sung, Pei-Shan Al-Ahdal, Mohammed Rayes, Julie Van Vliet, Sandra
Source	Medline; PMC
abstract	The protective roles of endosomal toll-like receptors (TLRs) and cytosolic nucleic acid sensors are well elucidated, but the pathogenic host factors during viral infections remain unclear. Spleen tyrosine kinase (Syk)-coupled C-type lectins (CLECs) CLEC2 and CLEC5A are highly expressed on platelets and myeloid cells, respectively. CLEC2 has been shown to recognize snake venom aggretin and the endogenous ligand podoplanin and acts as a critical regulator in the development and immunothrombosis. Although CLEC2 has been reported to interact with type I immunodeficiency virus (HIV-1), its role in viral infections is still unclear. CLEC5A binds to fucose and mannose moieties of dengue virus membrane glycans, as well as to N-acetylglucosamine (GlcNAc)/N-acetylmuramic acid (MurNAc) disaccharides that form the backbone of L. monocytogenes peptidoglycans. Recently, we demonstrated that both CLEC2 and CLEC5A are critical in microbe-induced “neutrophil extracellular trap” (NET) formation and proinflammatory cytokine production. Moreover, activation of CLEC2 by dengue virus (DV) and H5N1 influenza virus (IAV) induces the release of extracellular vesicles (EVs), which further enhance NETosis and proinflammatory cytokine production via CLEC5A and Toll-like receptor 2 (TLR2). These findings not only illustrate the immunomodulatory effects of EVs during platelet-leukocyte interactions, but also demonstrate the critical roles of CLEC2 and CLEC5A in acute viral infections.
has issue date	2019-12-06(xsd:dateTime)
bibo:doi	10.3389/fimmu.2019.02867
bibo:pmid	31867016
has license	cc-by
sha1sum (hex)	9e953d462385492fa9cc2ada05c1fd357de8afed
schema:url	https://doi.org/10.3389/fimmu.2019.02867
resource representing a document's title	CLEC2 and CLEC5A: Pathogenic Host Factors in Acute Viral Infections
has PubMed Central identifier	PMC6909378
has PubMed identifier	31867016
schema:publication	Front Immunol
resource representing a document's body	covid:9e953d462385492fa9cc2ada05c1fd357de8afed#body_text
is schema:about of	named entity 'PLATELETS' named entity 'GLYCANS' named entity 'FORMATION' named entity 'TYPE I' named entity 'PEPTIDOGLYCANS' named entity 'CRITICAL' named entity 'BINDS' named entity 'INDUCED' named entity 'MEMBRANE' named entity 'EVS' named entity 'ACUTE' named entity 'PATHOGENIC' named entity 'VIRAL INFECTIONS' named entity 'SPLEEN TYROSINE KINASE' named entity 'IMMUNODEFICIENCY VIRUS' named entity 'RECOGNIZE' named entity 'IMMUNOMODULATORY' named entity 'SNAKE VENOM' named entity 'TOLL-LIKE RECEPTOR 2' named entity 'NUCLEIC ACID' named entity 'ITS' named entity 'BUT' named entity 'FINDINGS' named entity 'WITH TYPE' named entity 'LEUKOCYTE' named entity 'TO INTERACT WITH' named entity 'ROLE' named entity 'IAV' named entity 'EVs' named entity 'trap' named entity 'Host' named entity 'CLEC2' covid:arg/9e953d462385492fa9cc2ada05c1fd357de8afed named entity 'MICROBE' named entity 'TOLL-LIKE RECEPTORS' named entity 'ENDOGENOUS LIGAND' named entity 'EXTRACELLULAR' named entity 'ENHANCE' named entity 'CLEC2' named entity 'RECENTLY' named entity 'H5N1 INFLUENZA' named entity 'N-ACETYLGLUCOSAMINE' named entity 'TYPE' named entity 'THESE' named entity 'TRAP' named entity 'FORM' named entity 'NETOSIS' named entity 'VIRAL INFECTIONS' named entity 'HOST' named entity 'PATHOGENIC' named entity 'CLEC5A' named entity 'PROINFLAMMATORY CYTOKINE' named entity 'EFFECTS' named entity 'HOST' named entity 'LECTINS' named entity 'DEMONSTRATED' named entity 'FUCOSE' named entity 'BACKBONE' named entity 'PLATELET' named entity 'ACETYLMURAMIC ACID' named entity 'DISACCHARIDES' named entity 'EXTRACELLULAR VESICLES' named entity 'REGULATOR' named entity 'DENGUE VIRUS' named entity 'UNCLEAR' named entity 'REPORTED' named entity 'EXPRESSED' named entity 'ACUTE' named entity 'SENSORS' named entity 'DEVELOPMENT' named entity 'INFLUENZA VIRUS' named entity 'ROLES' named entity 'RELEASE' named entity 'HIGHLY' named entity 'MANNOSE' named entity 'CLEC5A' named entity 'MYELOID CELLS'

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