About: Molecular identification and transcriptional regulation of porcine IFIT2 gene

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About: Molecular identification and transcriptional regulation of porcine IFIT2 gene Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Molecular identification and transcriptional regulation of porcine IFIT2 gene
Creator	Liu, · Jing, Xiaoyan Song, Yanfang Yang, Xiuqin Zhang, Caixia
Source	Medline; PMC
abstract	IFN-induced protein with tetratricopeptide repeats 2 (IFIT2) plays important roles in host defense against viral infection as revealed by studies in humans and mice. However, little is known on porcine IFIT2 (pIFIT2). Here, we performed molecular cloning, expression profile, and transcriptional regulation analysis of pIFIT2. pIFIT2 gene, located on chromosome 14, is composed of two exons and have a complete coding sequence of 1407 bp. The encoded polypeptide, 468 aa in length, has three tetratricopeptide repeat motifs. pIFIT2 gene was unevenly distributed in all eleven tissues studied with the most abundance in spleen. Poly(I:C) treatment notably strongly upregulated the mRNA level and promoter activity of pIFIT2 gene. Upstream sequence of 1759 bp from the start codon which was assigned +1 here has promoter activity, and deltaEF1 acts as transcription repressor through binding to sequences at position − 1774 to − 1764. Minimal promoter region exists within nucleotide position − 162 and − 126. Two adjacent interferon-stimulated response elements (ISREs) and two nuclear factor (NF)-κB binding sites were identified within position − 310 and − 126. The ISRE elements act alone and in synergy with the one closer to start codon having more strength, so do the NF-κB binding sites. Synergistic effect was also found between the ISRE and NF-κB binding sites. Additionally, a third ISRE element was identified within position − 1661 to − 1579. These findings will contribute to clarifying the antiviral effect and underlying mechanisms of pIFIT2.
has issue date	2018-04-06(xsd:dateTime)
bibo:doi	10.1007/s11033-018-4179-7
bibo:pmid	29623507
has license	no-cc
sha1sum (hex)	9e9088f15a252e6eb8a2601e24a01997cfd6c6b1
schema:url	https://doi.org/10.1007/s11033-018-4179-7
resource representing a document's title	Molecular identification and transcriptional regulation of porcine IFIT2 gene
has PubMed Central identifier	PMC7088635
has PubMed identifier	29623507
schema:publication	Mol Biol Rep
resource representing a document's body	covid:9e9088f15a252e6eb8a2601e24a01997cfd6c6b1#body_text
is schema:about of	named entity 'gene' named entity 'studies' named entity 'PORCINE' named entity 'POLYPEPTIDE' named entity 'VIRAL INFECTION' named entity 'TREATMENT' named entity 'INTERFERON' named entity 'UNDERLYING' named entity 'PLAYS' named entity 'REGION' named entity 'LEVEL' named entity 'UPREGULATED' named entity 'HAVE' named entity '126' named entity 'EXPRESSION PROFILE' named entity 'ASSIGNED' named entity 'IFN' named entity 'ANTIVIRAL' named entity 'PROMOTER' named entity 'MECHANISMS' named entity 'PROMOTER ACTIVITY' named entity 'ENCODED' named entity 'EFFECT' named entity 'IFIT2' named entity 'MOTIFS' named entity 'HOST DEFENSE' named entity 'MRNA' named entity 'FOUND' named entity 'GENE' named entity 'HUMANS' named entity 'POLY' named entity 'COMPOSED OF' named entity 'CHROMOSOME 14' named entity 'DISTRIBUTED' named entity 'POSITION' named entity 'UPSTREAM' named entity 'ACTS' named entity 'START CODON' named entity 'THESE' named entity 'BINDING SITES' named entity 'FACTOR' named entity 'BINDING' named entity 'MOLECULAR IDENTIFICATION' named entity 'IDENTIFIED' named entity 'RESPONSE ELEMENTS' named entity 'BAB' named entity 'STRENGTH' named entity '1407' named entity 'IMPORTANT' named entity 'ANALYSIS' named entity '162' named entity 'DELTAEF1' named entity 'COMPLETE' named entity 'KNOWN' named entity 'SEQUENCES' named entity 'ROLES' named entity 'PERFORMED' named entity '28I' named entity 'REPEATS' named entity 'MOLECULAR CLONING' named entity '310' named entity 'GENE' named entity 'ELEMENT' named entity 'STIMULATED' named entity 'PROTEIN ' named entity 'SEQUENCE' named entity 'ADJACENT' named entity 'TISSUES' named entity 'NUCLEAR' named entity 'INDUCED' named entity 'ISRE' named entity 'MINIMAL' named entity 'STUDIES' named entity '2B1' named entity 'TRANSCRIPTIONAL REGULATION' named entity 'PORCINE' named entity 'LENGTH'

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