About: Detection of severe acute respiratory syndrome Coronavirus-2 in the tears of patients with Coronavirus disease 2019

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About: Detection of severe acute respiratory syndrome Coronavirus-2 in the tears of patients with Coronavirus disease 2019 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Detection of severe acute respiratory syndrome Coronavirus-2 in the tears of patients with Coronavirus disease 2019
Creator	Safi, Sare Arabi, • Karimi, Saeed Shahraki, Toktam
Source	Medline; PMC
abstract	OBJECTIVES: Since there are few reports on the ocular involvement of coronavirus disease 2019 (COVID-19) patients, this study aimed to assess the presence of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) in the tears of patients with COVID-19. METHODS: In this prospective case series, nasopharyngeal and tear sampling of 43 patients with severe COVID-19 were performed. The quantitative reverse transcription polymerase chain reaction (RT-PCR) was conducted to detect SARS-CoV-2. Ocular and systemic signs and symptoms were recorded from their medical history. RESULTS: The mean age of patients was 56 ± 13 years. The average disease time from initiation of symptoms was 3.27 days, range: 1–7 days. Forty-one patients (95.3%) had fever at the time of sampling. Only one patient had conjunctivitis. Thirty (69.8%) nasopharyngeal and three (7%) tear samples were positive for SARS-CoV-2. The result of tear sample was positive in the patient with conjunctivitis. All patients with positive tear RT-PCR results had positive nasopharyngeal RT-PCR results. CONCLUSIONS: Ocular manifestation was rare in this series of severe COVID-19 patients, however, 7% of the patients had viral RNA in their conjunctival secretions. Therefore, possibility of ocular transmission should be considered even in the absence of ocular manifestations.
has issue date	2020-05-18(xsd:dateTime)
bibo:doi	10.1038/s41433-020-0965-2
bibo:pmid	32424329
has license	no-cc
sha1sum (hex)	9e24d4d6217488b3aec85f28a32e73984a71baea
schema:url	https://doi.org/10.1038/s41433-020-0965-2
resource representing a document's title	Detection of severe acute respiratory syndrome Coronavirus-2 in the tears of patients with Coronavirus disease 2019
has PubMed Central identifier	PMC7232592
has PubMed identifier	32424329
schema:publication	Eye (Lond)
resource representing a document's body	covid:9e24d4d6217488b3aec85f28a32e73984a71baea#body_text
is schema:about of	named entity 'SARS-CoV-2' named entity 'range' named entity 'severe' named entity 'tear' named entity 'COVID-19' named entity 'Objectives' named entity 'manifestations' named entity 'severe' named entity 'tear' named entity 'CONSIDERED' named entity 'CONJUNCTIVITIS' named entity 'TEAR' named entity 'TIME' named entity 'POSITIVE FOR' named entity 'SEVERE COVID-19' named entity 'NASOPHARYNGEAL' named entity 'MEAN' named entity 'SERIES' named entity 'CONCLUSIONS' named entity 'ABSENCE OF' named entity 'THIRTY' named entity 'ASSESS' named entity 'SAMPLING' named entity 'tear' named entity 'nasopharyngeal' named entity 'assess' named entity 'COVID-19' named entity 'All' named entity 'transmission' named entity 'chain reaction' named entity 'initiation' named entity 'RT-PCR' named entity 'reverse transcription polymerase chain reaction' named entity 'nasopharyngeal' named entity 'conjunctivitis' named entity 'COVID' named entity 'RT-PCR' named entity 'Coronavirus disease 2019' named entity 'severe acute respiratory syndrome Coronavirus' named entity 'Singapore' named entity 'foreign body' named entity 'China' named entity 'World Health Organization' named entity 'SARS-CoV-2' named entity 'oxygen saturation' named entity 'outbreak of the coronavirus' named entity 'SARS-CoV-2' named entity 'mucus' named entity 'chills' named entity 'cough' named entity 'disease transmission' named entity 'RT-PCR' named entity 'computed tomography' named entity 'clinical diagnosis' named entity 'unilateral or bilateral' named entity 'SARS outbreak' named entity 'conjunctivitis' named entity 'RT-PCR' named entity 'cough' named entity 'conjunctival' named entity 'cross contamination' named entity 'COVID' named entity 'highly contagious' named entity 'conjunctival' named entity 'sample size' named entity 'heart rate' named entity 'viral RNA' named entity 'SARS-CoV-2 virus' named entity 'COVID' named entity 'RNA' named entity 'SARS-CoV-2' named entity 'foreign body' named entity 'RT-PCR' named entity '69.8%' named entity 'ophthalmologists' named entity 'ICU' named entity 'nasopharyngeal' named entity 'RT-PCR'

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