About: GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses

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About: GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses
Creator	Cihlar, Tomas Jordan, Robert Siegel, Dustin Arvey, Aaron Flint, Mike Perron, Michel Shrivastava-Ranjan, Punya Sudhamsu, Jawahar Clarke, Michael Lo, Michael Mackman, Richard Nichol, Stuart Ray, Adrian Spiropoulou, Christina Mcmullan, Laura Hotard, Anne Hui, Hon
Source	Medline; PMC
abstract	GS-5734 is a monophosphate prodrug of an adenosine nucleoside analog that showed therapeutic efficacy in a non-human primate model of Ebola virus infection. It has been administered under compassionate use to two Ebola patients, both of whom survived, and is currently in Phase 2 clinical development for treatment of Ebola virus disease. Here we report the antiviral activities of GS-5734 and the parent nucleoside analog across multiple virus families, providing evidence to support new indications for this compound against human viruses of significant public health concern.
has issue date	2017-03-06(xsd:dateTime)
bibo:doi	10.1038/srep43395
bibo:pmid	28262699
has license	cc-by
sha1sum (hex)	9dd6e3df008179b4c54ac823f76192a8a174b62d
schema:url	https://doi.org/10.1038/srep43395
resource representing a document's title	GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses
has PubMed Central identifier	PMC5338263
has PubMed identifier	28262699
schema:publication	Sci Rep
resource representing a document's body	covid:9dd6e3df008179b4c54ac823f76192a8a174b62d#body_text
is schema:about of	named entity 'PNEUMO' named entity 'indications' named entity 'Ebola virus disease' named entity 'nucleoside analog' named entity 'IS A' named entity 'NON-HUMAN PRIMATE' named entity 'COMPASSIONATE USE' named entity 'CONCERN' named entity 'ACROSS' named entity 'THERAPEUTIC EFFICACY' named entity 'ADMINISTERED' named entity 'ACTIVITIES' named entity 'HUMAN' named entity 'EBOLA' named entity 'PROVIDING' named entity 'PARENT' named entity 'CURRENTLY' named entity 'NUCLEOSIDE ANALOG' named entity 'NEW' named entity 'COMPOUND' named entity 'PUBLIC HEALTH' named entity 'MULTIPLE' named entity 'EBOLA VIRUS DISEASE' named entity 'NUCLEOSIDE ANALOG' named entity 'PRODRUG' named entity 'SIGNIFICANT' named entity 'CLINICAL DEVELOPMENT' named entity 'GS-5734' named entity 'FILO' named entity 'ITS' named entity 'MODEL OF' named entity 'VIRUS' named entity 'VIRUSES' named entity 'FAMILIES' named entity 'ANTIVIRAL' named entity 'INDICATIONS' named entity 'PATIENTS' named entity 'GS-5734' named entity 'PARENT' named entity 'PARAMYXOVIRUSES' named entity 'PHASE 2' named entity 'ADENOSINE' named entity 'TO SUPPORT' named entity 'EBOLA VIRUS INFECTION' named entity 'REPORT' named entity 'HERE' named entity 'TREATMENT' named entity 'EVIDENCE' named entity 'virus' named entity 'human' named entity 'negative strand RNA viruses' named entity 'virus' named entity 'prodrug' named entity 'virus' named entity 'NiV' named entity 'Here' named entity 'Ebola' named entity 'nucleoside analog' named entity 'coronaviruses' named entity 'respiratory syncytial virus' named entity 'distance matrix' named entity 'phylogenetic' named entity 'wild-type' named entity 'macrophages' named entity 'GS-5734'

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