About: Critically ill healthcare workers with the middle east respiratory syndrome (MERS): A multicenter study

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About: Critically ill healthcare workers with the middle east respiratory syndrome (MERS): A multicenter study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Critically ill healthcare workers with the middle east respiratory syndrome (MERS): A multicenter study
Creator	Balkhy, Hanan Fowler, Robert Alraddadi, Basem Al-Omari, Awad Al-Hameed, Fahad Almotairi, Abdullah Jose, Jesna Kharaba, Ayman Mandourah, Yasser Qushmaq, Ismael Shalhoub, Sarah Hayden, Frederick Al Harthy, Abdulrahman Mady, Ahmed Abdulmomen, Ahmed Al Khatib, Kasim Al Qasim, Eman Al-Ghamdi, Ghassan Ragab, Ahmed Solaiman, Othman Al Mekhlafi, Ghaleb Al-Aithanid, Abdulsalam Al-Raddadiid, Rajaa Arabiid, Yaseen Mersonid, Laura
Source	Medline; PMC
abstract	BACKGROUND: Middle East Respiratory Syndrome Coronavirus (MERS-CoV) leads to healthcare-associated transmission to patients and healthcare workers with potentially fatal outcomes. AIM: We aimed to describe the clinical course and functional outcomes of critically ill healthcare workers (HCWs) with MERS. METHODS: Data on HCWs was extracted from a multi-center retrospective cohort study on 330 critically ill patients with MERS admitted between (9/2012–9/2015). Baseline demographics, interventions and outcomes were recorded and compared between survivors and non-survivors. Survivors were approached with questionnaires to elucidate their functional outcomes using Karnofsky Performance Status Scale. FINDINGS: Thirty-Two HCWs met the inclusion criteria. Comorbidities were recorded in 34% (11/32) HCW. Death resulted in 8/32 (25%) HCWs including all 5 HCWs with chronic renal impairment at baseline. Non-surviving HCW had lower PaO2/FiO2 ratios 63.5 (57, 116.2) vs 148 (84, 194.3), p = 0.043, and received more ECMO therapy compared to survivors, 9/32 (28%) vs 4/24 (16.7%) respectively (p = 0.02).Thirteen of the surviving (13/24) HCWs responded to the questionnaire. Two HCWs confirmed functional limitations. Median number of days from hospital discharge until the questionnaires were filled was 580 (95% CI 568, 723.5) days. CONCLUSION: Approximately 10% of critically ill patients with MERS were HCWs. Hospital mortality rate was substantial (25%). Patients with chronic renal impairment represented a particularly high-risk group that should receive extra caution during suspected or confirmed MERS cases clinical care assignment and during outbreaks. Long-term repercussions of critical illness due to MERS on HCWs in particular, and patients in general, remain unknown and should be investigated in larger studies.
has issue date	2018-11-15(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0206831
bibo:pmid	30439974
has license	cc-by
sha1sum (hex)	9dcd697b97cd39fbeaf2c5f8be7d0bc139b84629
schema:url	https://doi.org/10.1371/journal.pone.0206831
resource representing a document's title	Critically ill healthcare workers with the middle east respiratory syndrome (MERS): A multicenter study
has PubMed Central identifier	PMC6237307
has PubMed identifier	30439974
schema:publication	PLoS One
resource representing a document's body	covid:9dcd697b97cd39fbeaf2c5f8be7d0bc139b84629#body_text
is schema:about of	named entity 'INTENSIVE CARE' named entity 'Intensive Care' named entity 'King Faisal Specialist Hospital' named entity 'Research Center' named entity 'SPECIALIST' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'ASSOCIATED' named entity 'LEADS' named entity 'HEALTHCARE WORKERS' named entity 'TRANSMISSION' named entity 'PATIENTS' named entity 'FATAL OUTCOMES' named entity 'KING' named entity 'HOSPITAL' named entity 'HEALTHCARE' named entity 'RESEARCH CENTER' named entity 'DEPARTMENT' covid:arg/9dcd697b97cd39fbeaf2c5f8be7d0bc139b84629 named entity 'healthcare-associated' named entity 'Middle East Respiratory Syndrome Coronavirus' named entity 'T-cell' named entity 'respiratory failure' named entity 'Immune dysregulation' named entity 'pregnant women' named entity 'long-term' named entity 'post-traumatic stress disorder' named entity 'ICU' named entity 'critically ill' named entity 'MERS-CoV' named entity 'antiviral' named entity 'critically ill' named entity 'pregnant women' named entity 'MERS' named entity 'Coronavirus' named entity 'pneumonia' named entity 'infection control' named entity 'clinical characteristics' named entity 'cohort studies' named entity 'HCW' named entity 'cohort studies' named entity 'MERS' named entity 'MERS' named entity 'HCW' named entity 'renal impairment' named entity 'MERS' named entity 'MERS-CoV' named entity 'quality of life' named entity 'MERS' named entity 'MERS' named entity 'health care' named entity 'renal impairment' named entity 'MERS' named entity 'shortness of breath' named entity 'general population' named entity 'rescue therapy' named entity 'Descriptive statistics' named entity 'Middle East Respiratory Syndrome Coronavirus'

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