About: Oral lesions in SARS-COV-2 infected patients: could the oral cavity be a target organ?

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About: Oral lesions in SARS-COV-2 infected patients: could the oral cavity be a target organ? Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Oral lesions in SARS-COV-2 infected patients: could the oral cavity be a target organ?
Creator	Melo, Silva Migliorati, Cesar Roger, Alan Santos-Silva, Alan Ana, ; Bianca, Thaís Boas Do Prado, Villas Brandão, Dds, Brandão Dds, Santos-Silva Froelich, Ana Gladys, ; Gladys, D Gueiros, Alcino Luiz, ; Nesrallah, Alo Prado-Ribeiro, Ana Prado-Ribeiro, Carolina Thayanara, ; Thaís, Bianca Villas Boas Do Prado, Gladys
Source	Elsevier; PMC
abstract	Several viruses transmitted through saliva, such as herpes simplex virus, cytomegalovirus and Zika virus are capable of infecting and replicating in the oral mucosa leading to painful oral ulcers. Few studies have described COVID-19 oral manifestations. There is growing evidence that angiotensin-converting enzyme 2 (ACE2), the main host cell receptor of SARS-CoV-2, is highly expressed on the epithelial cells of the tongue and salivary glands, which may explain the development of dysgeusia in COVID-19 patients. Hence, it is important to understand if SARS-CoV-2 can infect and replicate in oral keratinocytes and fibroblasts, causing oral ulcerations and superficial necrosis. Herein we report a series of eight cases of COVID-19 infected patients with oral necrotic ulcers and aphthous-like ulcerations affecting tongue, lips, palate and oropharynx that developed early in the course of disease following the development of dysgeusia. A short review of the literature regarding the important role of ACE2 in SARS-CoV-2 cellular entry is also provided bringing new insights to oral keratinocytes and minor salivary glands as potential targets.
has issue date	2020-08-18(xsd:dateTime)
bibo:doi	10.1016/j.oooo.2020.07.014
has license	no-cc
sha1sum (hex)	9d9df2989d2dc21ff83616fb40c4796979959738
schema:url	https://doi.org/10.1016/j.oooo.2020.07.014
resource representing a document's title	Oral lesions in SARS-COV-2 infected patients: could the oral cavity be a target organ?
has PubMed Central identifier	PMC7434495
schema:publication	Oral Surg Oral Med Oral Pathol Oral Radiol
resource representing a document's body	covid:9d9df2989d2dc21ff83616fb40c4796979959738#body_text
is schema:about of	named entity 'Manuscript' named entity 'infected' named entity 'REFERENCES' named entity 'oral cavity' named entity 'Oral' named entity 'Oral' named entity 'word count' named entity 'SARS-COV-2' named entity 'viral replication' named entity 'São Carlos' named entity 'neutrophils' named entity 'dysgeusia' named entity 'infection' named entity 'surrogate marker' named entity 'kidneys' named entity 'COVID' named entity 'normal body temperature' named entity 'ulcers' named entity 'COVID' named entity 'heart rate' named entity 'erythematous' named entity 'intensive care unit' named entity 'ageusia' named entity 'HSV-1' named entity 'anosmia' named entity 'microorganism' named entity 'c-reactive protein' named entity 'ACE2' named entity 'severe pain' named entity 'hypertension' named entity 'epithelial cells' named entity 'ulceration' named entity 'oral ulcerations' named entity 'SARS-Cov-2' named entity 'allergy' named entity 'SARS-CoV-2' named entity 'gustatory' named entity 'March 11' named entity 'dysgeusia' named entity 'lower lip' named entity 'lymphocytes' named entity 'sore throat' named entity 'epidemiological data' named entity 'fatigue' named entity 'SARS-CoV-2' named entity 'dysgeusia' named entity 'Biochemical' named entity 'odynophagia' named entity 'dyspnea' named entity 'tropism' named entity 'serum glucose' named entity 'respiratory symptoms' named entity 'oxygen saturation' named entity 'C-reactive protein' named entity 'ulcerations' named entity 'body temperature' named entity 'fever' named entity 'quarantine' named entity 'dental offices' named entity 'Head and neck' named entity 'hemoglobin' named entity 'erythema multiforme' named entity 'fever'

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