About: Antiviral activity of a Bacillus sp. P34 peptide against pathogenic viruses of domestic animals

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About: Antiviral activity of a Bacillus sp. P34 peptide against pathogenic viruses of domestic animals Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antiviral activity of a Bacillus sp. P34 peptide against pathogenic viruses of domestic animals
Creator	Brandelli, Adriano Fischer, Geferson Caetano De Castro, Clarissa D', Gilberto Da Silva E Silva, Fábio De Lima, Marcelo De Oliveira Hübner, Silvia De Souza Da Motta, Amanda Sant'anna, Voltaire Scopel E Silva, Débora Vargas, Avila
Source	Medline; PMC
abstract	P34 is an antimicrobial peptide produced by a Bacillus sp. strain isolated from the intestinal contents of a fish in the Brazilian Amazon basin with reported antibacterial activity. The aim of this work was to evaluate the peptide P34 for its in vitro antiviral properties against canine adenovirus type 2 (CAV-2), canine coronavirus (CCoV), canine distemper virus (CDV), canine parvovirus type 2 (CPV-2), equine arteritis virus (EAV), equine influenza virus (EIV), feline calicivirus (FCV) and feline herpesvirus type 1 (FHV-1). The results showed that the peptide P34 exhibited antiviral activity against EAV and FHV-1. The peptide P34 inhibited the replication of EAV by 99.9% and FHV-1 by 94.4%. Virucidal activity was detected only against EAV. When P34 and EAV were incubated for 6 h at 37 °C the viral titer reduced from 10(4.5) TCID(50) to 10(2.75) TCID(50), showing a percent of inhibition of 98.6%. In conclusion, our results demonstrated that P34 inhibited EAV and FHV-1 replication in infected cell cultures and it showed virucidal activity against EAV. Since there is documented resistance to the current drugs used against herpesviruses and there is no treatment for equine viral arteritis, it is advisable to search for new antiviral compounds to overcome these infections.
has issue date	2014-10-09(xsd:dateTime)
bibo:pmid	25477947
has license	no-cc
sha1sum (hex)	9d97b122ebffbbf28052287cae39cd6c6d3d7cb6
resource representing a document's title	Antiviral activity of a Bacillus sp. P34 peptide against pathogenic viruses of domestic animals
has PubMed Central identifier	PMC4204951
has PubMed identifier	25477947
schema:publication	Braz J Microbiol
resource representing a document's body	covid:9d97b122ebffbbf28052287cae39cd6c6d3d7cb6#body_text
is schema:about of	named entity 'P34' named entity 'ANTIVIRAL ACTIVITY' named entity 'drugs' named entity 'P34' named entity 'feline herpesvirus' named entity 'activity' named entity 'P34' named entity 'PERCENT' named entity 'INFECTIONS' named entity 'INFECTED CELL' named entity 'USED' named entity 'STRAIN' named entity 'BACILLUS SP.' named entity 'CANINE CORONAVIRUS' named entity 'ANTIVIRAL' named entity 'INHIBITION' named entity 'DOCUMENTED' named entity 'P34' named entity 'ANTIMICROBIAL PEPTIDE' named entity '99.9' named entity 'FHV' named entity 'RESULTS' named entity 'EQUINE VIRAL ARTERITIS' named entity 'PEPTIDE' named entity 'ACTIVITY' named entity 'PROPERTIES' named entity 'CURRENT' named entity 'CANINE DISTEMPER VIRUS' named entity 'CANINE PARVOVIRUS' named entity 'PEPTIDE' named entity 'FELINE CALICIVIRUS' named entity 'EQUINE INFLUENZA VIRUS' named entity 'IN VITRO' named entity 'THESE' named entity 'DOMESTIC ANIMALS' named entity 'ISOLATED' named entity 'INTESTINAL CONTENTS' named entity 'PATHOGENIC' named entity 'REPLICATION' named entity 'FELINE HERPESVIRUS TYPE 1' named entity 'VIRUSES' named entity 'BACILLUS SP.' named entity 'INHIBITED' named entity 'EQUINE ARTERITIS VIRUS' named entity 'BRAZILIAN' named entity 'INCUBATED' named entity 'NO TREATMENT' named entity 'TYPE 2' named entity 'ANTIVIRAL ACTIVITY' named entity 'SEARCH' named entity 'HERPESVIRUSES' named entity 'CONCLUSION' named entity 'CANINE ADENOVIRUS TYPE 2' named entity 'NEW' named entity 'DEMONSTRATED' named entity 'REDUCED' named entity 'ITS' named entity 'ANTIBACTERIAL' named entity 'CELL CULTURES' named entity 'DRUGS' named entity 'OUR' named entity 'WORK' named entity 'TCID' named entity '4.5' named entity 'FISH' named entity 'EVALUATE' named entity 'RESISTANCE TO' named entity 'DETECTED' named entity 'REPORTED' named entity 'OVERCOME' named entity '2.75' named entity 'AMAZON BASIN' named entity 'VIRAL TITER'

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