About: Immunohistochemical, in situ hybridization, and ultrastructural localization of SARS-associated coronavirus in lung of a fatal case of severe acute respiratory syndrome in Taiwan

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About: Immunohistochemical, in situ hybridization, and ultrastructural localization of SARS-associated coronavirus in lung of a fatal case of severe acute respiratory syndrome in Taiwan Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immunohistochemical, in situ hybridization, and ultrastructural localization of SARS-associated coronavirus in lung of a fatal case of severe acute respiratory syndrome in Taiwan
Creator	Su, Ih-Jen Hsiao, Cheng-Hsiang Rollin, Pierre Guarner, Jeannette Zaki, Sherif Shieh, Wun-Ju Wu, Mu-Zong Goldsmith, Cynthia Paddock, Christopher Ba, Laurie Mph, Michelle Tatti Phd, Kathleen
Source	Elsevier; Medline; PMC
abstract	Summary This article describes the pathological studies of fatal severe acute respiratory syndrome (SARS) in a 73-year-old man during an outbreak of SARS in Taiwan, 2003. Eight days before onset of symptoms, he visited a municipal hospital that was later identified as the epicenter of a large outbreak of SARS. On admission to National Taiwan University Hospital in Taipei, the patient experienced chest tightness, progressive dyspnea, and low-grade fever. His condition rapidly deteriorated with increasing respiratory difficulty, and he died 7 days after admission. The most prominent histopathologic finding was diffuse alveolar damage of the lung. Immunohistochemical and in situ hybridization assays demonstrated evidence of SARS-associated coronavirus (SARS-CoV) infection in various respiratory epithelial cells, predominantly type II pneumocytes, and in alveolar macrophages in the lung. Electron microscopic examination also revealed coronavirus particles in the pneumocytes, and their identity was confirmed as SARS-CoV by immunogold labeling electron microscopy. This report is the first to describe the cellular localization of SARS-CoV in human lung tissue by using a combination of immunohistochemistry, double-stain immunohistochemistry, in situ hybridization, electron microscopy, and immunogold labeling electron microscopy. These techniques represent valuable laboratory diagnostic modalities and provide insights into the pathogenesis of this emerging infection.
has issue date	2005-03-31(xsd:dateTime)
bibo:doi	10.1016/j.humpath.2004.11.006
bibo:pmid	15791576
has license	els-covid
sha1sum (hex)	9d71568fa7f2aa6c23bdbdc4367254a5c499f86a
schema:url	https://doi.org/10.1016/j.humpath.2004.11.006
resource representing a document's title	Immunohistochemical, in situ hybridization, and ultrastructural localization of SARS-associated coronavirus in lung of a fatal case of severe acute respiratory syndrome in Taiwan
has PubMed Central identifier	PMC7112064
has PubMed identifier	15791576
schema:publication	Human Pathology
resource representing a document's body	covid:9d71568fa7f2aa6c23bdbdc4367254a5c499f86a#body_text
is schema:about of	named entity 'LUNG' named entity 'died' named entity 'front matter' named entity 'dyspnea' named entity 'describe' named entity 'ultrastructural' named entity 'CASE' named entity 'STAIN' named entity 'PARTICLES' named entity 'PROMINENT' named entity 'DIFFUSE ALVEOLAR DAMAGE' named entity 'PATHOLOGICAL' named entity 'UNIVERSITY HOSPITAL' named entity 'DOUBLE' named entity 'CONFIRMED' named entity 'IN SITU HYBRIDIZATION' named entity 'HUMAN LUNG' named entity 'FATAL' named entity 'ALVEOLAR MACROPHAGES' named entity 'CELLULAR LOCALIZATION' named entity 'MATTER' named entity 'MICROSCOPIC EXAMINATION' named entity 'ONSET OF SYMPTOMS' named entity 'OUTBREAK' named entity 'ADMISSION' named entity 'EPICENTER' named entity 'INFECTION' named entity 'MUNICIPAL HOSPITAL' named entity 'DYSPNEA' named entity 'TAIWAN' named entity 'IDENTIFIED' named entity 'EXPERIENCED' named entity 'MAN' named entity 'ELECTRON' named entity 'IMMUNOHISTOCHEMISTRY' named entity 'SARS-COV' named entity 'LARGE' named entity 'LUNG TISSUE' named entity 'TAIWAN' named entity 'SARS-ASSOCIATED CORONAVIRUS' named entity 'FATAL' named entity 'RESPIRATORY' named entity 'VARIOUS' named entity 'INCREASING' named entity 'DETERIORATED' named entity 'ARTICLE' named entity 'CONDITION' named entity 'IDENTITY' named entity 'IN SITU HYBRIDIZATION' named entity 'LOCALIZATION' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'ELECTRON MICROSCOPY' named entity 'CORONAVIRUS' named entity 'COMBINATION' named entity 'IMMUNOGOLD LABELING' named entity 'SARS' named entity 'EVIDENCE OF' named entity 'LOW-GRADE FEVER' named entity 'TYPE II' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'THEIR' named entity 'REVEALED' named entity 'PROGRESSIVE' named entity 'TAIPEI' named entity 'ON ADMISSION' named entity 'PNEUMOCYTES' named entity 'DAYS' named entity 'LUNG' named entity 'STUDIES' named entity 'NATIONAL TAIWAN UNIVERSITY'

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