About: Exacerbation of Japanese Encephalitis by CD11c(hi) Dendritic Cell Ablation Is Associated with an Imbalance in Regulatory Foxp3(+) and IL-17(+)CD4(+) Th17 Cells and in Ly-6C(hi) and Ly-6C(lo) Monocytes

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About: Exacerbation of Japanese Encephalitis by CD11c(hi) Dendritic Cell Ablation Is Associated with an Imbalance in Regulatory Foxp3(+) and IL-17(+)CD4(+) Th17 Cells and in Ly-6C(hi) and Ly-6C(lo) Monocytes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Exacerbation of Japanese Encephalitis by CD11c(hi) Dendritic Cell Ablation Is Associated with an Imbalance in Regulatory Foxp3(+) and IL-17(+)CD4(+) Th17 Cells and in Ly-6C(hi) and Ly-6C(lo) Monocytes
Creator	Uyangaa, Erdenebelig Kim, Jin Patil, Ajit Bum, Seong Choi, Jin Kug Eo, Seong Hossain, Altaf Mohd, Ferdaus
topic	covid:9d12f3a201435c9d24dc9b356283edf8bd3a234d#this
Source	PMC
abstract	Japanese encephalitis (JE) is neuroinflammation characterized by uncontrolled infiltration of peripheral leukocytes into the central nervous system (CNS). We previously demonstrated exacerbation of JE following CD11c(hi) dendritic cell (DC) ablation in CD11c-DTR transgenic mice. Moreover, CD11c(hi) DC ablation led to abnormal differentiation of CD11b(+)Ly-6C(hi) monocytes and enhanced permeability of the blood-brain barrier (BBB), resulting in promoting the progression of JE. Here, we examined changes in lymphoid and myeloid-derived leukocyte subpopulations associated with pro- and anti-inflammation during JE progression. The analyses of this study focused on regulatory CD4(+)Foxp3(+) regulatory T cells (Tregs), IL-17(+)CD4(+) Th17 cells, and CD11b(+)Ly-6C(hi) and Ly-6C(lo) monocytes. CD11c(hi) DC ablation resulted in the accumulation of IL-17(+)CD4(+) Th17 cells in the CNS, thereby leading to lower ratio of Tregs to Th17 cells. This result was corroborated by the higher expression levels of IL-17 and RORγT in CD4(+) T cells from the brains of CD11c(hi) DC-ablated mice. In addition, CD11c(hi) DC-ablated mice showed higher frequency and total number of inflammatory CD11b(+)Ly-6C(hi) monocytes, whereas CD11b(+)Ly-6C(lo) monocytes were detected with lower frequency and total number in CD11c(hi) DC-ablated mice. Furthermore, CD11c(hi) DC ablation altered the phenotype and function of CD11b(+)Ly-6C(lo) monocytes, resulting in lower levels of activation marker and anti-inflammatory cytokine (IL-10 and TGF-β) expression. Collectively, these results indicate that CD11c(hi) DC ablation caused an imbalance in CD4(+) Th17/Treg cells and CD11b(+)Ly-6C(hi)/Ly-6C(lo) monocytes in the lymphoid tissue and CNS during JE progression. This imbalanced orchestration of pro- and anti-inflammatory leukocytes following CD11c(hi) DC ablation may contribute to the exacerbation of JE.
has issue date	2017-06-20(xsd:dateTime)
bibo:doi	10.4110/in.2017.17.3.192
bibo:pmid	28680381
has license	cc-by-nc
sha1sum (hex)	9d12f3a201435c9d24dc9b356283edf8bd3a234d
schema:url	https://doi.org/10.4110/in.2017.17.3.192
resource representing a document's title	Exacerbation of Japanese Encephalitis by CD11c(hi) Dendritic Cell Ablation Is Associated with an Imbalance in Regulatory Foxp3(+) and IL-17(+)CD4(+) Th17 Cells and in Ly-6C(hi) and Ly-6C(lo) Monocytes
has PubMed Central identifier	PMC5484650
has PubMed identifier	28680381
schema:publication	Immune Netw
resource representing a document's body	covid:9d12f3a201435c9d24dc9b356283edf8bd3a234d#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/9d12f3a201435c9d24dc9b356283edf8bd3a234d
is schema:about of	named entity 'CELL ABLATION' named entity 'JAPANESE ENCEPHALITIS' named entity 'IMBALANCE' named entity 'FUNCTION' named entity 'DETECTED' named entity 'EXAMINED' named entity 'ANTI-INFLAMMATORY CYTOKINE' named entity 'REGULATORY' named entity 'PERMEABILITY' named entity 'CONTRIBUTE ' named entity 'LEVELS' named entity 'MICE' named entity 'FREQUENCY' named entity 'CYTOKINE ' named entity 'PROMOTING' named entity 'ABNORMAL DIFFERENTIATION' named entity 'HIGHER' named entity 'DERIVED' named entity 'ACTIVATION' named entity 'RESULTING IN' named entity 'IL-17' named entity 'PRO-' named entity 'TOTAL NUMBER' named entity 'UNCONTROLLED' named entity 'DENDRITIC CELL' named entity 'RORGT' named entity 'EXACERBATION' named entity 'RESULT' named entity 'NETWORK' named entity 'THESE' named entity 'CAUSED' named entity 'NEUROINFLAMMATION' named entity 'demonstrated' named entity 'Foxp3' named entity 'CD4' named entity 'leukocytes' named entity 'Tregs' named entity 'expression' named entity 'CD11c' named entity 'Treg cells' named entity 'Japanese Encephalitis' named entity 'DENDRITIC CELL' named entity 'CHANGES' named entity 'ALTERED' named entity 'ADDITION' named entity 'LY-6C' named entity 'TRANSGENIC MICE' named entity 'MONOCYTES' covid:arg/9d12f3a201435c9d24dc9b356283edf8bd3a234d named entity 'PERIPHERAL' named entity 'PREVIOUSLY' named entity 'INFLAMMATORY' named entity 'RESULTS' named entity 'LOWER' named entity 'REGULATORY T CELLS' named entity 'ABLATION' named entity 'LY-6C' named entity 'ASSOCIATED WITH' named entity 'TH17 CELLS' named entity 'COMMUNICATION' named entity 'FOXP3' named entity 'CD11C' named entity 'CD4' named entity 'T CELLS' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'MONOCYTES' named entity 'BLOOD-BRAIN BARRIER' named entity 'CNS' named entity 'HERE' named entity 'STUDY' named entity 'LEADING' named entity 'JAPANESE ENCEPHALITIS'

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