About: In Vitro Bactericidal and Virucidal Efficacy of Povidone-Iodine Gargle/Mouthwash Against Respiratory and Oral Tract Pathogens

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About: In Vitro Bactericidal and Virucidal Efficacy of Povidone-Iodine Gargle/Mouthwash Against Respiratory and Oral Tract Pathogens Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	In Vitro Bactericidal and Virucidal Efficacy of Povidone-Iodine Gargle/Mouthwash Against Respiratory and Oral Tract Pathogens
Creator	Markus, Koburger-Janssen Torsten, Maren Zorn, Eickmann
Source	Medline; PMC
abstract	INTRODUCTION: Recent virus epidemics and rising antibiotic resistance highlight the importance of hygiene measures to prevent and control outbreaks. We investigated the in vitro bactericidal and virucidal efficacy of povidone-iodine (PVP-I) 7% gargle/mouthwash at defined dilution against oral and respiratory tract pathogens. METHODS: PVP-I was tested against Klebsiella pneumoniae and Streptococcus pneumoniae according to bactericidal quantitative suspension test EN13727 and against severe acute respiratory syndrome and Middle East respiratory syndrome coronaviruses (SARS-CoV and MERS-CoV), rotavirus strain Wa and influenza virus A subtype H1N1 according to virucidal quantitative suspension test EN14476. PVP-I 7% gargle/mouthwash was diluted 1:30 with water to a concentration of 0.23% (the recommended concentration for “real-life” use in Japan) and tested at room temperature under clean conditions [0.3 g/l bovine serum albumin (BSA), viruses only] and dirty conditions (3.0 g/l BSA + 3.0 ml/l erythrocytes) as an interfering substance for defined contact times (minimum 15 s). Rotavirus was tested without protein load. A ≥ 5 log(10) (99.999%) decrease of bacteria and ≥ 4 log(10) (99.99%) reduction in viral titre represented effective bactericidal and virucidal activity, respectively, per European standards. RESULTS: PVP-I gargle/mouthwash diluted 1:30 (equivalent to a concentration of 0.23% PVP-I) showed effective bactericidal activity against Klebsiella pneumoniae and Streptococcus pneumoniae and rapidly inactivated SARS-CoV, MERS-CoV, influenza virus A (H1N1) and rotavirus after 15 s of exposure. CONCLUSION: PVP-I 7% gargle/mouthwash showed rapid bactericidal activity and virucidal efficacy in vitro at a concentration of 0.23% PVP-I and may provide a protective oropharyngeal hygiene measure for individuals at high risk of exposure to oral and respiratory pathogens. FUNDING: Mundipharma Research GmbH & Co. KG (MRG).
has issue date	2018-04-09(xsd:dateTime)
bibo:doi	10.1007/s40121-018-0200-7
bibo:pmid	29633177
has license	no-cc
sha1sum (hex)	9d02db669e8701c83186d7d3aae69da2f2cb3d34
schema:url	https://doi.org/10.1007/s40121-018-0200-7
resource representing a document's title	In Vitro Bactericidal and Virucidal Efficacy of Povidone-Iodine Gargle/Mouthwash Against Respiratory and Oral Tract Pathogens
has PubMed Central identifier	PMC5986684
has PubMed identifier	29633177
schema:publication	Infect Dis Ther
resource representing a document's body	covid:9d02db669e8701c83186d7d3aae69da2f2cb3d34#body_text
is schema:about of	named entity 'IN VITRO' named entity 'GARGLE' named entity 'TRACT' named entity 'RESPIRATORY' named entity 'PATHOGENS' named entity 'EFFICACY' named entity 'POVIDONE-IODINE' named entity 'ORAL' named entity 'pathogens' named entity 'vaccination' named entity 'cytopathic effects' named entity 'vaccination' named entity 'swine flu outbreak in 2009' named entity 'mucosal surfaces' named entity 'methanol' named entity 'respiratory infection' named entity 'PVP-I' named entity 'bacteria' named entity 'aerosols' named entity 'MERS-CoV' named entity 'viruses' named entity 'hygiene' named entity 'influenza' named entity 'PVP-I' named entity 'virucidal' named entity 'H5N3' named entity 'hygiene' named entity 'influenza' named entity 'antibiotics' named entity 'gargle' named entity 'CHG' named entity 'PVP-I' named entity 'pathogens' named entity 'URTIs' named entity 'nonenveloped' named entity 'viral replication' named entity 'gram-negative' named entity 'virus' named entity 'Oral hygiene' named entity 'gargle' named entity 'Ebola' named entity 'morbidity' named entity '1:300' named entity 'virus' named entity 'gargling' named entity 'PVP-I' named entity 'virus' named entity 'dangerous pathogens' named entity 'horseradish peroxidase' named entity 'adenovirus' named entity 'microbial' named entity 'Klebsiella pneumoniae' named entity 'viruses' named entity 'nosocomial' named entity 'antiviral drugs' named entity 'oral cavity' named entity 'PVP-I' named entity '1:300' named entity 'gargling' named entity 'self-limiting' named entity 'ATCC' named entity 'SARS-CoV' named entity 'epidemiological' named entity 'gargle' named entity 'Klebsiella pneumoniae' named entity 'PVP-I' named entity 'PVP-I' named entity 'lecithin' named entity 'viruses' named entity 'pathogens' named entity 'rotavirus' named entity 'pathogens' named entity 'PVP-I' named entity 'clinical studies' named entity 'rotavirus' named entity 'gargle' named entity 'MERS-CoV' named entity 'protease' named entity 'minimum contact'

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