About: Epidemiology, Co-Infections, and Outcomes of Viral Pneumonia in Adults: An Observational Cohort Study

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Epidemiology, Co-Infections, and Outcomes of Viral Pneumonia in Adults: An Observational Cohort Study
Creator	Buller, Richard Storch, Gregory Bledsoe, Stephanie Hampton, Nicholas Meyers, Shelby Ritchie, David Kollef, Marin Micek, Scott Crotty, Matthew
Source	Medline; PMC
abstract	Advanced technologies using polymerase-chain reaction have allowed for increased recognition of viral respiratory infections including pneumonia. Co-infections have been described for several respiratory viruses, especially with influenza. Outcomes of viral pneumonia, including cases with co-infections, have not been well described. This was observational cohort study conducted to describe hospitalized patients with viral pneumonia including co-infections, clinical outcomes, and predictors of mortality. Patients admitted from March 2013 to November 2014 with a positive respiratory virus panel (RVP) and radiographic findings of pneumonia within 48 h of the index RVP were included. Co-respiratory infection (CRI) was defined as any organism identification from a respiratory specimen within 3 days of the index RVP. Predictors of in-hospital mortality on univariate analysis were evaluated in a multivariate model. Of 284 patients with viral pneumonia, a majority (51.8%) were immunocompromised. A total of 84 patients (29.6%) were found to have a CRI with 48 (57.6%) having a bacterial CRI. Viral CRI with HSV, CMV, or both occurred in 28 patients (33.3%). Fungal (16.7%) and other CRIs (7.1%) were less common. Many patients required mechanical ventilation (54%) and vasopressor support (36%). Overall in-hospital mortality was high (23.2%) and readmissions were common with several patients re-hospitalized within 30 (21.1%) and 90 days (36.7%) of discharge. Predictors of in-hospital mortality on multivariate regression included severity of illness factors, stem-cell transplant, and identification of multiple respiratory viruses. In conclusion, hospital mortality is high among adult patients with viral pneumonia and patients with multiple respiratory viruses identified may be at a higher risk.
has issue date	2015-12-18(xsd:dateTime)
bibo:doi	10.1097/md.0000000000002332
bibo:pmid	26683973
has license	cc-by
sha1sum (hex)	9cfaf4c8791d75c45d2d5c52a6e2da74363d2565
schema:url	https://doi.org/10.1097/md.0000000000002332
resource representing a document's title	Epidemiology, Co-Infections, and Outcomes of Viral Pneumonia in Adults: An Observational Cohort Study
has PubMed Central identifier	PMC5058945
has PubMed identifier	26683973
schema:publication	Medicine (Baltimore)
resource representing a document's body	covid:9cfaf4c8791d75c45d2d5c52a6e2da74363d2565#body_text
is schema:about of	named entity 'CO-INFECTIONS' named entity 'POLYMERASE' named entity 'PNEUMONIA' named entity 'HAVE' named entity 'RESPIRATORY VIRUSES' named entity 'CHAIN REACTION' named entity 'OBSERVATIONAL' named entity 'respiratory infections' named entity 'cases' named entity 'Pneumonia' named entity 'ADULTS' covid:arg/9cfaf4c8791d75c45d2d5c52a6e2da74363d2565 named entity 'RESPIRATORY INFECTIONS' named entity 'OUTCOMES' named entity 'VIRAL PNEUMONIA' named entity 'COHORT STUDY' named entity 'CO-INFECTIONS' named entity 'EPIDEMIOLOGY' named entity 'TECHNOLOGIES' named entity 'RECOGNITION' named entity 'ADVANCED' named entity 'OUTCOMES' named entity 'VIRAL' named entity 'INCLUDING' named entity 'INFLUENZA' named entity 'INCREASED' named entity 'USING' named entity 'VIRAL PNEUMONIA' named entity 'CASES' named entity 'ALLOWED' named entity 'DESCRIBED' named entity 'viruses' named entity 'viral pneumonia' named entity 'Advanced technologies' named entity 'Cohort Study' named entity 'radiographic' named entity 'Staphylococcus aureus' named entity 'co-infection' named entity 'co-infection' named entity 'ICU' named entity 'antibacterial' named entity 'Fisher's exact test' named entity 'assay' named entity 'viral pneumonia' named entity 'zanamivir' named entity 'chronic obstructive pulmonary disease' named entity 'ICU' named entity 'CMV' named entity 'viruses' named entity 'pneumonia' named entity 'HSV' named entity 'toxin' named entity 'rhinovirus' named entity 'respiratory infections' named entity 'AIDS' named entity 'hMPV' named entity 'APACHE II' named entity 'pathogens' named entity 'infection' named entity 'risk of death' named entity 'critically ill' named entity 'RSV' named entity 'viruses' named entity 'vasopressor' named entity 'immune response' named entity 'comorbidity' named entity 'ICU' named entity 'viruses' named entity 'co-infection' named entity '2009 H1N1 influenza pandemic' named entity 'adenovirus' named entity 'viruses' named entity 'viral pneumonia'

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