About: Human Parainfluenza Virus-Associated Respiratory Tract Infection among Children and Genetic Analysis of HPIV-3 Strains in Beijing, China

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About: Human Parainfluenza Virus-Associated Respiratory Tract Infection among Children and Genetic Analysis of HPIV-3 Strains in Beijing, China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Human Parainfluenza Virus-Associated Respiratory Tract Infection among Children and Genetic Analysis of HPIV-3 Strains in Beijing, China
Creator	Zhang, Yan Liu, Chunyan Shen, Kunling Xie, Zhengde An, Junjing Ji, Yixin Xu, Wenbo Cui, Aili Mao, Naiying Zhu, Zhen Yang, Weizhong Wang, Huanhuan Wang, Huiling Xu, Songtao Zhang, Xinxin
Source	Medline; PMC
abstract	The relevance of human parainfluenza viruses (HPIVs) to the epidemiology of acute respiratory infections (ARI) in China is unclear. From May 2008 to September 2010, 443 nasopharyngeal aspirates (NPAs) from hospitalized pediatric patients (age from 1 to 93 months) in Beijing were collected and screened for HPIVs and other common respiratory viruses by real-time RT-PCR. Sixty-two of 443 samples were positive for HPIVs with 4 positive for HPIV-2 and 58 positive for HPIV-3, indicating that HPIV-3 was the predominant virus present during the study period. A phylogenetic tree based on all the available HN (hemagglutinin-neuraminidase) sequences of HPIV-3 indicated that three distinct clusters (A,B, and C) were circulating with some temporal and regional clustering. Cluster C was further divided into sub-clusters, C1, C2, C3 and C4. HPIV-3 from Beijing isolates belonged to sub-cluster C3, and were grouped with the isolates from two Provinces of China and the neighboring country of Japan. Genetic analysis based on entire HN gene revealed that the HPIV-3 isolates from Beijing were highly similar with 97.2%–100% identity at the nucleotide level and these could be divided into two closely related lineages, C3a and C3b. These findings suggested that there was co-circulation of multiple lineages of HPIV-3 in the Beijing region during the study period. This is the first study to describe the epidemiology and molecular characterization of HPIVs in China.
has issue date	2012-08-28(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0043893
bibo:pmid	22937119
has license	cc-by
sha1sum (hex)	9ce08e8f877a798f4ff11d70112b69f92fc2427f
schema:url	https://doi.org/10.1371/journal.pone.0043893
resource representing a document's title	Human Parainfluenza Virus-Associated Respiratory Tract Infection among Children and Genetic Analysis of HPIV-3 Strains in Beijing, China
has PubMed Central identifier	PMC3429441
has PubMed identifier	22937119
schema:publication	PLoS One
resource representing a document's body	covid:9ce08e8f877a798f4ff11d70112b69f92fc2427f#body_text
is schema:about of	named entity 'ARI' named entity 'human parainfluenza viruses' named entity 'Beijing' named entity 'ASSOCIATED' named entity 'CHILDREN' named entity 'RELEVANCE' named entity 'CHINA' named entity 'HUMAN PARAINFLUENZA VIRUSES' named entity 'EPIDEMIOLOGY' named entity 'CHINA' named entity 'HUMAN PARAINFLUENZA VIRUS' named entity 'RESPIRATORY TRACT INFECTION' named entity 'GENETIC ANALYSIS' named entity 'ACUTE RESPIRATORY INFECTIONS' named entity 'BEIJING' named entity 'HPIV-3' named entity 'STRAINS' named entity 'UNCLEAR' named entity 'Genetic' named entity 'China' named entity 'HPIV-1' named entity 'positive control' named entity 'sequenced' named entity 'HPIV' named entity 'PCR' named entity 'OC43' named entity 'young children' named entity 'anti-sense' named entity 'HPIV' named entity 'Saudi Arabia' named entity 'nucleotide' named entity 'respiratory tract infection' named entity 'vaccination' named entity 'HPIV-1' named entity 'Beijing' named entity 'coding region' named entity 'Canada' named entity 'infection' named entity 'young children' named entity 'HPIV-1' named entity 'mainland China' named entity 'virus' named entity 'glycoprotein' named entity 'primer' named entity 'amino acid sequences' named entity 'hemagglutinin' named entity 'viruses' named entity 'HPIV' named entity 'infection' named entity '6-carboxyfluorescein' named entity 'PCR' named entity 'reverse transcription polymerase chain reaction' named entity 'cough' named entity 'reverse transcription' named entity 'HMPV' named entity 'biological functions' named entity 'viruses' named entity 'HPIV' named entity 'diagnostic assays' named entity 'frame-shift' named entity 'proof reading' named entity 'viruses' named entity 'PCR' named entity 'genetic diversity' named entity 'phylogenetic analyses' named entity 'Tom Hall' named entity 'China'

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