About: Polyomaviruses-associated respiratory infections in HIV-infected and HIV-uninfected children

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Polyomaviruses-associated respiratory infections in HIV-infected and HIV-uninfected children
Creator	Madhi, Shabir Kuschner, Zachary Kuwanda, Locadiah Madimabe, Richard Rabede, Zelda Cutland, Clare Adrian, Peter Klugman, Keith Nunes, Marta
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: Two recently discovered polyomaviruses (PyV), WU and KI, have been identified in respiratory-tract specimens from children with acute respiratory infections, although there are limited data in HIV-infected children. OBJECTIVES: To determine the prevalence and clinical manifestations of WUPyV and KIPyV-associated lower respiratory tract infections (LRTIs) hospitalization in HIV-infected and -uninfected children; and probe the role of pneumococcal co-infection. STUDY DESIGN: Nasopharyngeal aspirates were collected from a cohort of 39,836 children randomized to receive 9-valent pneumococcal conjugate vaccine (PCV9) or placebo when hospitalized for LRTIs, and were screened by PCR for WUPyV, KIPyV and other respiratory viruses. RESULTS: In placebo-recipients the prevalence of WUPyV was 6.3% (18/285) in HIV-infected and 13.9% (66/476) in HIV-uninfected children (p = 0.002). In WUPyV-positive LRTIs HIV-infected children had lower oxygen saturation at admission and a higher case fatality rate (11.1% vs. 0%; p = 0.04). KIPyV was identified in 10.2% (29/285) of HIV-infected and in 7.4% (35/476) of HIV-uninfected placebo-recipients with LRTIs (p = 0.13). HIV-infected compared to HIV-uninfected children with KIPyV-positive LRTIs had lower oxygen saturation, higher respiratory rate and longer duration of hospitalization. Co-infections with other respiratory-viruses were detected in 65.5% of WUPyV-positive LRTIs and in 75.0% of KIPyV-positive LRTIs. Among HIV-uninfected children, there was a lower incidence of hospitalization for clinical pneumonia episodes in which KIPyV (80%; 95% CI: 41, 93) and WUPyV (49%; 95% CI: 9, 71) were identified among PCV9-recipients compared to placebo-recipients. CONCLUSIONS: Polyomaviruses were commonly identified in HIV-infected and -uninfected children hospitalized for LRTIs, frequently in association with other viruses and may contribute to the pathogenesis of pneumococcal pneumonia.
has issue date	2014-10-28(xsd:dateTime)
bibo:doi	10.1016/j.jcv.2014.10.013
bibo:pmid	25467863
has license	no-cc
sha1sum (hex)	9cdb6e1de26241f4502b23f0f56292e619b9bdc2
schema:url	https://doi.org/10.1016/j.jcv.2014.10.013
resource representing a document's title	Polyomaviruses-associated respiratory infections in HIV-infected and HIV-uninfected children
has PubMed Central identifier	PMC7173307
has PubMed identifier	25467863
schema:publication	J Clin Virol
resource representing a document's body	covid:9cdb6e1de26241f4502b23f0f56292e619b9bdc2#body_text
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