About: Crimean-Congo Hemorrhagic Fever in Humanized Mice Reveals Glial Cells as Primary Targets of Neurological Infection

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About: Crimean-Congo Hemorrhagic Fever in Humanized Mice Reveals Glial Cells as Primary Targets of Neurological Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Crimean-Congo Hemorrhagic Fever in Humanized Mice Reveals Glial Cells as Primary Targets of Neurological Infection
Creator	Bergeron, Éric Zivcec, Marko Zaki, Sherif Goldsmith, Cynthia Nichol, Stuart Spiropoulou, Christina Keck, James Spengler, Jessica Keating, M Coleman-Mccray, Joann Bollweg, Brigid Harmon, Jessica Mcelroy, Anita
Source	Medline; PMC
abstract	Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral hemorrhagic disease seen exclusively in humans. Central nervous system (CNS) infection and neurological involvement have also been reported in CCHF. In the current study, we inoculated NSG-SGM3 mice engrafted with human hematopoietic CD34(+) stem cells with low-passage CCHF virus strains isolated from human patients. In humanized mice, lethal disease develops, characterized by histopathological change in the liver and brain. To date, targets of neurological infection and disease have not been investigated in CCHF. CNS disease in humanized mice was characterized by gliosis, meningitis, and meningoencephalitis, and glial cells were identified as principal targets of infection. Humanized mice represent a novel lethal model for studies of CCHF countermeasures, and CCHF-associated CNS disease. Our data suggest a role for astrocyte dysfunction in neurological disease and identify key regions of infection in the CNS for future investigations of CCHF.
has issue date	2017-05-08(xsd:dateTime)
bibo:doi	10.1093/infdis/jix215
bibo:pmid	28482001
has license	hybrid-oa
sha1sum (hex)	9ca8879f5a14ceb3ef1a73068956f3ac638d8669
schema:url	https://doi.org/10.1093/infdis/jix215
resource representing a document's title	Crimean-Congo Hemorrhagic Fever in Humanized Mice Reveals Glial Cells as Primary Targets of Neurological Infection
has PubMed Central identifier	PMC5853341
has PubMed identifier	28482001
schema:publication	The Journal of Infectious Diseases
resource representing a document's body	covid:9ca8879f5a14ceb3ef1a73068956f3ac638d8669#body_text
is schema:about of	named entity 'dysfunction' named entity 'mice' named entity 'future' named entity 'TARGETS' named entity 'ROLE' named entity 'CRIMEAN-CONGO HEMORRHAGIC FEVER' named entity 'CD34' named entity 'MENINGITIS' named entity 'LIVER' named entity 'AND BRAIN' named entity 'SEEN' named entity 'PASSAGE' named entity 'HAVE' named entity 'VIRAL' named entity 'NOVEL' named entity 'LOW' named entity 'CNS' named entity 'INVESTIGATED' named entity 'STUDIES' named entity 'GLIAL CELLS' named entity 'IDENTIFY' named entity 'IDENTIFIED' named entity 'MODEL' named entity 'NEUROLOGICAL DISEASE' named entity 'CCHF VIRUS' named entity 'CURRENT' named entity 'NEUROLOGICAL' named entity 'DISEASE' named entity 'STUDY' named entity 'HEMATOPOIETIC' named entity 'PRINCIPAL' named entity 'MICE' named entity 'SUGGEST' named entity 'CRIMEAN-CONGO HEMORRHAGIC FEVER' named entity 'REVEALS' named entity 'KEY' named entity 'ASTROCYTE' named entity 'HUMAN' named entity 'REGIONS' named entity 'FUTURE' named entity 'NEUROLOGICAL INFECTION' named entity 'DATE' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'GLIOSIS' named entity 'HISTOPATHOLOGICAL' named entity 'STRAINS' named entity 'TARGETS' named entity 'LETHAL' named entity 'NEUROLOGICAL INFECTION' named entity 'GLIAL CELLS' named entity 'HUMANIZED MICE' named entity 'TICK' named entity 'INVESTIGATIONS' named entity 'HUMANS' named entity 'STEM CELLS' named entity 'CHARACTERIZED' named entity 'HUMANIZED MICE' named entity 'MENINGOENCEPHALITIS' named entity 'PATIENTS' named entity 'REPORTED' named entity 'HEMORRHAGIC DISEASE' named entity 'DEVELOPS' named entity 'OUR' named entity 'INVOLVEMENT' named entity 'IS A' named entity 'DATA' named entity 'ISOLATED' named entity 'REPRESENT' named entity 'CNS DISEASE'

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