About: Hot, humid air decontamination of aircraft confirmed that high temperature and high humidity are critical for inactivation of infectious, enveloped ribonucleic acid (RNA) virus

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About: Hot, humid air decontamination of aircraft confirmed that high temperature and high humidity are critical for inactivation of infectious, enveloped ribonucleic acid (RNA) virus Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Hot, humid air decontamination of aircraft confirmed that high temperature and high humidity are critical for inactivation of infectious, enveloped ribonucleic acid (RNA) virus
Creator	Buhr, Tony Young, Alice Mackie, Ryan Miller, Charles Barnette, Harold Bensman, Misty Bohmke, Matthew Borgers-Klonkowski, Erica Gutting, Bradford Hamilton, Shelia Hammer, Emlyn Hammon, Mark Innocenti, Jennifer Kennihan, Neil Kimani, Monique Lilly, Samuel Luck, Brooke Minter, Zachary Osborn, Emily Yates, Vanessa
topic	covid:9c61e7f6c95d674d337943915c3f8e25a815970c#this
Source	BioRxiv
abstract	Aims To develop infectious (live/dead) enveloped virus test indicators and Response Surface Methodology (RSM) models that evaluate survival of an enveloped ribonucleic acid (RNA) virus on contaminated aircraft materials after exposure to hot, humid air (HHA). Methods and Results Enveloped RNA bacteriophage Phi6 (Φ6) was dried on wiring insulation, aircraft performance coating (APC), polypropylene, and nylon at ≥ 8 log10 plaque-forming units (PFU) test coupon-1. Only 2.4 log10 inactivation was measured on APC at 70°Celsius (°C), 5% relative humidity (RH) after 24 h. In contrast, HHA RSM models showed a 90% probability of a 7-log10 inactivation at ≥63°C, 90% RH after 1 h, and decontamination kinetics were similar across different materials. HHA decontamination of C-130 and C-17 aircraft showed >7 log10 and ≥5.9 log10 inactivation of enveloped virus on 100 and 110 test indicators, respectively, with a 1-h treatment, excluding ramp-up and ramp-down times. Conclusions Enveloped RNA virus test indicators were successfully developed, lab tested for HHA decontamination, analyzed for RSM, and field-tested in aircraft demonstrations. Significance and Impact of the Study The utility of HHA decontamination was demonstrated after inactivating enveloped RNA virus on aircraft with a 1-h HHA treatment within aircraft temperature and RH limits.
has issue date	2020-07-20(xsd:dateTime)
bibo:doi	10.1101/2020.07.20.212365
has license	biorxiv
sha1sum (hex)	9c61e7f6c95d674d337943915c3f8e25a815970c
schema:url	https://doi.org/10.1101/2020.07.20.212365
resource representing a document's title	Hot, humid air decontamination of aircraft confirmed that high temperature and high humidity are critical for inactivation of infectious, enveloped ribonucleic acid (RNA) virus
schema:publication	bioRxiv
resource representing a document's body	covid:9c61e7f6c95d674d337943915c3f8e25a815970c#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/9c61e7f6c95d674d337943915c3f8e25a815970c
is schema:about of	named entity 'acid' named entity 'critical' named entity 'Running' named entity 'enveloped' named entity 'temperature' named entity 'EVALUATE' named entity 'aircraft' named entity 'humid' named entity 'humid air' named entity 'RNA' named entity 'RNA' named entity 'Enveloped Virus' named entity 'virus' named entity 'decontamination' named entity 'Decontamination' named entity 'Humid Air' named entity 'pathovar' named entity 'log10' named entity 'EPA' named entity 'enveloped virus' named entity 'serially diluted' named entity 'enveloped virus' named entity 'enveloped virus' named entity 'log reduction' named entity 'Van Etten' named entity 'SARS-CoV-2' named entity 'HHA' named entity 'orders of magnitude' named entity 'smallpox' named entity 'assay' named entity 'C-130' named entity 'Design of Experiment' named entity 'log10' named entity 'lab tests' named entity 'pH7' named entity 'enveloped virus' named entity 'spore' named entity 'biosafety' named entity 'Dover Air Force Base' named entity '5.5' named entity 'C-17' named entity 'mammalian cells' named entity 'Autoclaved' named entity 'data fitting' named entity 'C-130' named entity 'protein' named entity 'cauterized' named entity 'ethanol' named entity 'virus' named entity 'Design of Experiments' named entity 'Switzerland' named entity 'HHA' named entity 'sterilization' named entity 'Escherichia coli' named entity 'Microbial' named entity 'Virus' named entity 'host cells' named entity 'humidity' named entity 'virus' named entity 'HHA' named entity 'HHA' named entity 'spores' named entity 'COVID19'

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