About: Coinfection with Haemophilus parasuis serovar 4 increases the virulence of porcine circovirus type 2 in piglets

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About: Coinfection with Haemophilus parasuis serovar 4 increases the virulence of porcine circovirus type 2 in piglets Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Coinfection with Haemophilus parasuis serovar 4 increases the virulence of porcine circovirus type 2 in piglets
Creator	He, Qigai Liu, Xiaoli Wang, Yang Li, Wentao Charreyre, Catherine Fan, Shenxian Gu, Changqin Liu, Shuqing
Source	Medline; PMC
abstract	BACKGROUND: Postweaning multisystemic wasting syndrome (PMWS) is an emerging disease in swine. Pigs with PMWS are often infected with a variety of other pathogens, including bacteria, viruses and mycoplasm, in addition to porcine circovirus type 2 (PCV2). PCV2 and Haemophilus parasuis serovar 4 (HPS4) coinfection remain epidemic in China. METHODS: Here we report construction of a three-week-old naturally farrowed, colostrum-deprived (NFCD) piglet’s infection model and demonstrate that PCV2-infected piglets with the HPS4 coinfection increased the virulence of PCV2 and these pathogens interact acquired PMWS. RESULTS: All the single infected piglets were transiently bacteremic or viremic. All the PCV2/HPS4 coinfected piglets developed PMWS, characterized by dyspnea, anorexia, prostration and lose weight severely. Co-infection with PCV2 and HPS4 resulted in an increased amount of virus in serum and tissues, presented a slower generation and lower levels of antibodies against PCV2. Co-infection with PCV2 and HPS4 resulted in further reductions in total and differential peripheral blood leukocyte counts. Meantime, PCV2/ HPS4 coinfection potentiated the severity of lung and lymphoid lesions by PCV2-associated, increased the virulence of PCV2-antigen and enhanced the incidence of PMWS in piglets. CONCLUSION: Co-infection with PCV2 and HPS4 induce the exacerbation of system injuries and enhance the pathogenicity of PCV2 in piglets.
has issue date	2017-11-21(xsd:dateTime)
bibo:doi	10.1186/s12985-017-0890-6
bibo:pmid	29157279
has license	cc-by
sha1sum (hex)	9c492e76efc05b17e67a3e09c7e3ac44cca89e29
schema:url	https://doi.org/10.1186/s12985-017-0890-6
resource representing a document's title	Coinfection with Haemophilus parasuis serovar 4 increases the virulence of porcine circovirus type 2 in piglets
has PubMed Central identifier	PMC5696968
has PubMed identifier	29157279
schema:publication	Virol J
resource representing a document's body	covid:9c492e76efc05b17e67a3e09c7e3ac44cca89e29#body_text
is schema:about of	named entity 'China' named entity 'virulence' named entity 'type' named entity 'SEROVAR' covid:arg/9c492e76efc05b17e67a3e09c7e3ac44cca89e29 named entity 'BACKGROUND' named entity 'HAEMOPHILUS PARASUIS' named entity 'PORCINE CIRCOVIRUS TYPE 2' named entity 'PIGS' named entity 'COINFECTION' named entity 'PORCINE CIRCOVIRUS TYPE 2' named entity 'HAEMOPHILUS PARASUIS' named entity 'VIRULENCE' named entity 'COINFECTION' named entity 'CHINA' named entity 'INCREASES' named entity 'INCLUDING' named entity 'SEROVAR' named entity 'DISEASE' named entity 'BACTERIA' named entity 'INFECTED' named entity 'PATHOGENS' named entity 'VARIETY' named entity 'EPIDEMIC' named entity 'SWINE' named entity 'ADDITION' named entity 'VIRUSES' named entity 'POSTWEANING MULTISYSTEMIC WASTING SYNDROME' named entity 'type' named entity 'Pigs' named entity 'porcine circovirus' named entity 'Haemophilus' named entity 'genome replication' named entity 'IL-1β' named entity 'severe weight loss' named entity 'PMWS' named entity 'PCV2' named entity 'synergistic' named entity 'kidney' named entity 'PCV2' named entity 'PCV2' named entity 'inflammatory responses' named entity 'immune complex' named entity 'HPS4' named entity 'IL-1β' named entity 'vaccine' named entity 'HPS4' named entity 'PCV2' named entity 'inflammatory cytokines' named entity 'Hubei Province' named entity 'PCV2' named entity 'PCV2' named entity 'monocytes' named entity 'ad libitum' named entity 'virulence' named entity 'LPS' named entity 'diarrhea' named entity 'secretion' named entity 'bacterial pathogens' named entity 'heat shock proteins' named entity 'infection' named entity 'coinfected' named entity 'PCV2' named entity 'PCV2' named entity 'PCV2' named entity 'PCV2' named entity 'coronavirus' named entity 'porcine parvovirus' named entity 'control group' named entity 'mRNA expression' named entity 'mRNA expression' named entity 'infection' named entity 'co-infection' named entity 'HPS4'

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