About: Characterizing the Pregnancy Immune Phenotype: Results of the Viral Immunity and Pregnancy (VIP) Study

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About: Characterizing the Pregnancy Immune Phenotype: Results of the Viral Immunity and Pregnancy (VIP) Study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Characterizing the Pregnancy Immune Phenotype: Results of the Viral Immunity and Pregnancy (VIP) Study
Creator	Moran, Thomas Kraus, T Kraus, Thomas Lo, Y Sperling, Rhoda Garrido, Jose Engel, S Engel, Stephanie Escribese, M Escribese, Maria Garrido, J Kellerman, : Kellerman, Lisa Lo, Yungtai Loubeau, M Loubeau, Martine Singh, T Singh, Tricia Sperling, R Wallenstein, : Wallenstein, S Wallenstein, Sylvan
Source	PMC
abstract	PURPOSE: The increased risk of morbidity and mortality from certain microbial infections and the demonstrated improvements in the clinical course of some autoimmune diseases support the existence of pregnancy-related alterations in immune status. Elucidating the changes in innate and adaptive immunity during gestation may improve pregnancy outcomes and facilitate the development of targeted therapies for autoimmune diseases. METHOD: The Viral Immunity and Pregnancy (VIP) study evaluated over 50 subjects longitudinally at three time points during pregnancy and at two time points post-delivery. Leukocyte enumeration was performed; functional responses of NK cells and CD4 T cells were analyzed, and soluble factors such as cytokines, defensins, and steroid hormones were measured in maternal blood. RESULTS: In comparison to the post-partum period, the latter part of pregnancy was characterized by significant increases in blood phagocytes and pDCs and decreases in the number and activity of NK and T cells. Alterations were found in antimicrobial proteins and serum cytokines. CONCLUSIONS: These data show that pregnancy is not a period of immunosuppression but an alteration in immune priorities characterized by a strengthening of innate immune barriers and a concomitant reduction in adaptive/inflammatory immunity in the later stages of pregnancy.
has issue date	2011-12-24(xsd:dateTime)
bibo:doi	10.1007/s10875-011-9627-2
bibo:pmid	22198680
has license	no-cc
sha1sum (hex)	9c24ea320a94f89c6802d968806b3d5273882ecf
schema:url	https://doi.org/10.1007/s10875-011-9627-2
resource representing a document's title	Characterizing the Pregnancy Immune Phenotype: Results of the Viral Immunity and Pregnancy (VIP) Study
has PubMed Central identifier	PMC7086597
has PubMed identifier	22198680
schema:publication	J Clin Immunol
resource representing a document's body	covid:9c24ea320a94f89c6802d968806b3d5273882ecf#body_text
is schema:about of	named entity 'morbidity' named entity 'improve' named entity 'targeted therapies' named entity 'Pregnancy' named entity 'CHANGES' covid:arg/9c24ea320a94f89c6802d968806b3d5273882ecf named entity 'development' named entity 'improvements' named entity 'Pregnancy' named entity 'morbidity' named entity 'autoimmune diseases' named entity 'pregnancy' named entity 'pregnancy' named entity 'autoimmune diseases' named entity 'immune status' named entity 'gestation' named entity 'LOD' named entity 'morbidity' named entity 'CD56' named entity 'influenza' named entity 'TNFα' named entity 'pregnancy' named entity 'post partum' named entity 'serum samples' named entity 'vaccine' named entity 'IL-4' named entity 'vaccine' named entity 'alcohol' named entity 'MCP-1' named entity 'cytokines' named entity 'monocytes' named entity 'influenza' named entity 'postpartum' named entity 'Invitrogen' named entity 'Millipore' named entity 'viral replication' named entity 'CD8 T cells' named entity 'estrogen' named entity 'CD19+' named entity 'phagocytes' named entity 'viable pregnancy' named entity 'immunosuppressive therapy' named entity 'PBMCs' named entity 'MIP-1β' named entity 'phagocytic cells' named entity 'influenza infection' named entity 'immune response' named entity 'NK cell' named entity 'postpartum' named entity 'CD4' named entity 'informed consent' named entity 'anemia' named entity 'immunoregulatory' named entity 'antiviral' named entity 'CD3' named entity 'IL-8' named entity 'prenatal visit' named entity 'memory T cells' named entity 'Th2' named entity 'CD3'

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