About: Accelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Accelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Accelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence
Creator	Chen, Min Jiang, Jin Lian, Xiao-Dong Pang, Wei Song, Jia-Hao Tian, Ren-Rong Zhang, Gao-Hong Zhang, Lin-Tao Zhang, Ming-Xu Zhang, Xiao-Liang Zheng, Hong-Yi Zheng, Yong-Tang
Source	Medline; PMC
abstract	The elderly population infected with HIV-1 is often characterized by the rapid AIDS progression and poor treatment outcome, possibly because of immunosenescence resulting from both HIV infection and aging. However, this hypothesis remains to be fully tested. Here, we studied 6 young and 12 old Chinese rhesus macaques (ChRM) over the course of three months after simian immunodeficiency virus (SIV) SIVmac239 infection. Old ChRM showed a higher risk of accelerated AIDS development than did young macaques, owing to rapidly elevated plasma viral loads and decreased levels of CD4(+) T cells. The low frequency of naïve CD4(+) T cells before infection was strongly predictive of an increased disease progression, whereas the severe depletion of CD4(+) T cells and the rapid proliferation of naïve lymphocytes accelerated the exhaustion of naïve lymphocytes in old ChRM. Moreover, in old ChRM, a robust innate host response with defective regulation was associated with a compensation for naïve T cell depletion and a high level of immune activation. Therefore, we suggest that immunosenescence plays an important role in the accelerated AIDS progression in elderly individuals and that SIV-infected old ChRM may be a favorable model for studying AIDS pathogenesis and researching therapies for elderly AIDS patients.
has issue date	2017-02-24(xsd:dateTime)
bibo:doi	10.1038/s41598-017-00084-0
bibo:pmid	28232735
has license	cc-by
sha1sum (hex)	9bd22fc1297bd20710ca26f6e79b6339d576bb74
schema:url	https://doi.org/10.1038/s41598-017-00084-0
resource representing a document's title	Accelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence
has PubMed Central identifier	PMC5428349
has PubMed identifier	28232735
schema:publication	Sci Rep
resource representing a document's body	covid:9bd22fc1297bd20710ca26f6e79b6339d576bb74#body_text
is schema:about of	named entity 'exhaustion' named entity 'simian immunodeficiency virus (SIV)' named entity 'Old' named entity 'AIDS' named entity 'pathogenesis' named entity 'disease' named entity 'host response' named entity 'T cells' named entity 'innate' named entity 'rhesus macaques' covid:arg/9bd22fc1297bd20710ca26f6e79b6339d576bb74 named entity 'tested' named entity 'rapidly' named entity 'predictive' named entity 'accelerated' named entity 'patients' named entity 'CD4' named entity 'plasma' named entity 'immune' named entity 'CD4' named entity 'population' named entity 'infected' named entity 'Therefore' named entity 'regulation' named entity 'immunosenescence' named entity 'AIDS' named entity 'pathogenesis' named entity 'CD4 +' named entity 'elderly individuals' named entity 'rhesus macaques' named entity 'immunosenescence' named entity 'rhesus macaques' named entity 'T cell' named entity 'remains' named entity 'CD4 +' named entity 'expression levels' named entity 'SIV' named entity 'anergy' named entity 'STLV' named entity 't-tests' named entity 'IBM' named entity 'TAKARA' named entity 'infection' named entity 'infection' named entity 'signaling pathways' named entity 'thymic' named entity 'Ki67' named entity 'inflammation' named entity 'lymphocytes' named entity 'gene' named entity 'infection' named entity 'mRNA expression' named entity 'Immunophenotyping' named entity 'CD4' named entity 'CD4 +' named entity 'CD8' named entity 'SIV' named entity 'CD80' named entity 'infection' named entity 'Mamu' named entity 'down-regulated' named entity 'cell count' named entity 'lymphocytes' named entity 'naïve B cell' named entity 'flow cytometry' named entity 'flow cytometric' named entity 'RPL13A' named entity 'AIDS' named entity 'CD8 +' named entity 'gradient centrifugation'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software