About: Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses

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About: Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses
Creator	Wuhrer, Manfred Sanders, Rogier Vlaar, Alexander Van Drunen, Cornelis Brouwer, Philip Caniels, Tom Van Baarle, Frank Van Gils, Marit Vidarsson, Gestur Bonta, Peter Van Der Straten, Karlijn Allahverdiyeva, Sona Aman, Jurjan Bogaard, Jan Chen, Hung-Jen De Taeye, Steven De Winther, Menno Den Dunnen, Jeroen Godelieve De Bree, Golebski, Korneliusz Griffith, Guillermo Hoepel, Willianne Jonkers, René Larsen, Mads Linty, Federica Manz, Xue Neele, Annette Nouta, Jan Umc Covid-19 Biobank, Amsterdam Willemsen, Lisa
source	BioRxiv
abstract	For yet unknown reasons, severely ill COVID-19 patients often become critically ill around the time of activation of adaptive immunity. Here, we show that anti-Spike IgG from serum of severely ill COVID-19 patients induces a hyper-inflammatory response by human macrophages, which subsequently breaks pulmonary endothelial barrier integrity and induces microvascular thrombosis. The excessive inflammatory capacity of this anti-Spike IgG is related to glycosylation changes in the IgG Fc tail. Moreover, the hyper-inflammatory response induced by anti-Spike IgG can be specifically counteracted in vitro by use of the active component of fostamatinib, an FDA- and EMA-approved therapeutic small molecule inhibitor of Syk. One sentence summary Anti-Spike IgG promotes hyper-inflammation.
has issue date	2020-07-13(xsd:dateTime)
bibo:doi	10.1101/2020.07.13.190140
has license	biorxiv
sha1sum (hex)	9bc583d41faedb2f01ee075c3b0b888531715482
schema:url	https://doi.org/10.1101/2020.07.13.190140
resource representing a document's title	Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses
schema:publication	bioRxiv
resource representing a document's body	covid:9bc583d41faedb2f01ee075c3b0b888531715482#body_text
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