About: Serious Adverse Health Events, Including Death, Associated with Ingesting Alcohol-Based Hand Sanitizers Containing Methanol

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About: Serious Adverse Health Events, Including Death, Associated with Ingesting Alcohol-Based Hand Sanitizers Containing Methanol — Arizona and New Mexico, May–June 2020 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Serious Adverse Health Events, Including Death, Associated with Ingesting Alcohol-Based Hand Sanitizers Containing Methanol — Arizona and New Mexico, May–June 2020
Creator	Clarke, Kevin Chang, Arthur Deblina Datta, ; Kenneth, ; Schmit, Kristine Bixler, Danae Brandon, ; Brooks, Daniel Dudley, Steven Lind, Jennifer Mayette, Annaliese Melgar, Michael Pindyck, Talia Seifert, Steven Smolinske, Susan Yip, Luke Farshad, ; Komatsu, K Shirazi, Mazda Warrick, J
Source	Medline; PMC
abstract	Alcohol-based hand sanitizer is a liquid, gel, or foam that contains ethanol or isopropanol used to disinfect hands. Hand hygiene is an important component of the U.S. response to the emergence of SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19). If soap and water are not readily available, CDC recommends the use of alcohol-based hand sanitizer products that contain at least 60% ethyl alcohol (ethanol) or 70% isopropyl alcohol (isopropanol) in community settings (1); in health care settings, CDC recommendations specify that alcohol-based hand sanitizer products should contain 60%-95% alcohol (≥60% ethanol or ≥70% isopropanol) (2). According to the Food and Drug Administration (FDA), which regulates alcohol-based hand sanitizers as an over-the-counter drug, methanol (methyl alcohol) is not an acceptable ingredient. Cases of ethanol toxicity following ingestion of alcohol-based hand sanitizer products have been reported in persons with alcohol use disorder (3,4). On June 30, 2020, CDC received notification from public health partners in Arizona and New Mexico of cases of methanol poisoning associated with ingestion of alcohol-based hand sanitizers. The case reports followed an FDA consumer alert issued on June 19, 2020, warning about specific hand sanitizers that contain methanol. Whereas early clinical effects of methanol and ethanol poisoning are similar (e.g., headache, blurred vision, nausea, vomiting, abdominal pain, loss of coordination, and decreased level of consciousness), persons with methanol poisoning might develop severe anion-gap metabolic acidosis, seizures, and blindness. If left untreated methanol poisoning can be fatal (5). Survivors of methanol poisoning might have permanent visual impairment, including complete vision loss; data suggest that vision loss results from the direct toxic effect of formate, a toxic anion metabolite of methanol, on the optic nerve (6). CDC and state partners established a case definition of alcohol-based hand sanitizer-associated methanol poisoning and reviewed 62 poison center call records from May 1 through June 30, 2020, to characterize reported cases. Medical records were reviewed to abstract details missing from poison center call records. During this period, 15 adult patients met the case definition, including persons who were American Indian/Alaska Native (AI/AN). All had ingested an alcohol-based hand sanitizer and were subsequently admitted to a hospital. Four patients died and three were discharged with vision impairment. Persons should never ingest alcohol-based hand sanitizer, avoid use of specific imported products found to contain methanol, and continue to monitor FDA guidance (7). Clinicians should maintain a high index of suspicion for methanol poisoning when evaluating adult or pediatric patients with reported swallowing of an alcohol-based hand sanitizer product or with symptoms, signs, and laboratory findings (e.g., elevated anion-gap metabolic acidosis) compatible with methanol poisoning. Treatment of methanol poisoning includes supportive care, correction of acidosis, administration of an alcohol dehydrogenase inhibitor (e.g., fomepizole), and frequently, hemodialysis.
has issue date	2020-08-14(xsd:dateTime)
bibo:doi	10.15585/mmwr.mm6932e1
bibo:pmid	32790662
has license	cc-by
sha1sum (hex)	9b488e265b10808f135210f716dbf7a4b939ea69
schema:url	https://doi.org/10.15585/mmwr.mm6932e1
resource representing a document's title	Serious Adverse Health Events, Including Death, Associated with Ingesting Alcohol-Based Hand Sanitizers Containing Methanol — Arizona and New Mexico, May–June 2020
has PubMed Central identifier	PMC7440116
has PubMed identifier	32790662
schema:publication	MMWR Morb Mortal Wkly Rep
resource representing a document's body	covid:9b488e265b10808f135210f716dbf7a4b939ea69#body_text
is schema:about of	named entity 'Alcohol-Based Hand Sanitizers' named entity 'hand sanitizer' named entity 'clinical diagnosis' named entity 'alcohol-based hand sanitizers' named entity 'nausea' named entity 'ethanol poisoning' named entity 'fda' named entity 'supportive care' named entity 'bicarbonate' named entity 'methanol' named entity 'methanol' named entity 'medical attention' named entity 'signs and symptoms' named entity 'alcohol use disorder' named entity 'alcohol' named entity 'Medical records' named entity 'hand sanitizer' named entity 'CDC' named entity 'Alaska Native' named entity 'mEq/L' named entity 'Arizona' named entity 'milliequivalents' named entity 'methanol poisoning' named entity 'alcohol' named entity 'methanol' named entity 'health care' named entity 'dermal' named entity 'poison' named entity 'methanol poisoning' named entity 'alcohol-based hand sanitizers' named entity 'disinfect' named entity 'Arizona' named entity 'metabolite' named entity 'methanol poisoning' named entity 'public health' named entity 'pediatric patients' named entity 'poison' named entity 'public health' named entity 'methanol poisoning' named entity 'United States' named entity 'FDA' named entity 'Alcohol-based hand sanitizers' named entity 'methanol poisoning' named entity '3, 4' named entity 'washing hands' named entity 'sequelae' named entity 'medical attention' named entity 'visual impairment' named entity 'methanol' named entity 'index of suspicion' named entity 'COVID' named entity 'handwashing' named entity 'hand sanitizer' named entity 'methanol' named entity 'soap and water' named entity 'acidosis' named entity 'disability' named entity 'ethanol' named entity '3, 4' named entity 'metabolic acidosis' named entity 'alcohol dehydrogenase' named entity 'U.S.'

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