About: Pre- and Postexposure Use of Human Monoclonal Antibody against H5N1 and H1N1 Influenza Virus in Mice: Viable Alternative to Oseltamivir

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Pre- and Postexposure Use of Human Monoclonal Antibody against H5N1 and H1N1 Influenza Virus in Mice: Viable Alternative to Oseltamivir
Creator	Goudsmit, Jaap Koudstaal, Wouter Brakenhoff, Just Friesen, Robert Koldijk, Martin Weverling, Gerrit Cornelissen, Lisette
source	PMC
abstract	New strategies to prevent and treat influenza virus infections are urgently needed. A recently discovered class of monoclonal antibodies (mAbs) neutralizing an unprecedented spectrum of influenza virus subtypes may have the potential for future use in humans. Here, we assess the efficacies of CR6261, which is representative of this novel class of mAbs, and oseltamivir in mice. We show that a single injection with 15 mg/kg CR6261 outperforms a 5-day course of treatment with oseltamivir (10 mg/kg/day) with respect to both prophylaxis and treatment of lethal H5N1 and H1N1 infections. These results justify further preclinical evaluation of broadly neutralizing mAbs against influenza virus for the prevention and treatment of influenza virus infections
has issue date	2009-12-15(xsd:dateTime)
bibo:doi	10.1086/648378
bibo:pmid	19911992
has license	no-cc
sha1sum (hex)	9aa38acaf58c4f7bdc2b8fce4a75f660abf314a2
schema:url	https://doi.org/10.1086/648378
resource representing a document's title	Pre- and Postexposure Use of Human Monoclonal Antibody against H5N1 and H1N1 Influenza Virus in Mice: Viable Alternative to Oseltamivir
has PubMed Central identifier	PMC7110231
has PubMed identifier	19911992
schema:publication	J Infect Dis
resource representing a document's body	covid:9aa38acaf58c4f7bdc2b8fce4a75f660abf314a2#body_text
is schema:about of	named entity 'MICE' named entity 'Antibody' named entity 'H1N1' named entity 'Human' named entity 'NOVEL' named entity 'POTENTIAL' named entity 'TO PREVENT' named entity 'INFLUENZA VIRUS' named entity 'MONOCLONAL ANTIBODIES' named entity 'RESULTS' named entity 'HERE' named entity 'HUMANS' named entity 'PREVENTION' named entity 'JUSTIFY' named entity 'PRECLINICAL' named entity 'CLASS' named entity 'EVALUATION' named entity 'MICE' named entity 'OSELTAMIVIR' named entity 'VIABLE' named entity 'ALTERNATIVE' named entity 'H1N1 INFLUENZA' named entity 'PRE' named entity 'INFLUENZA VIRUS' named entity 'OSELTAMIVIR' named entity 'TREAT' named entity 'NEW' named entity 'SINGLE' named entity 'H5N1' named entity 'SPECTRUM' named entity 'ASSESS' named entity 'NEEDED' named entity 'INFECTIONS' named entity 'H1N1' named entity 'RECENTLY' named entity 'MG%' named entity 'THESE' named entity 'TREATMENT' named entity 'INJECTION' named entity 'PROPHYLAXIS' named entity 'HUMAN' named entity 'MAY HAVE' named entity 'LETHAL' named entity 'SUBTYPES' named entity 'REPRESENTATIVE' named entity 'MONOCLONAL ANTIBODY' named entity 'FUTURE' named entity 'USE' named entity 'COURSE' named entity 'USE OF' named entity 'RESPECT' named entity 'STRATEGIES' named entity 'DAY' named entity 'H5N1' named entity 'monoclonal antibodies' named entity 'evaluation' named entity 'neutralizing' named entity 'infections' named entity 'mice' named entity 'mAbs' named entity 'Influenza Virus' named entity 'spectrum' named entity 'antibody' named entity 'CR6261' named entity 'pharmacy' named entity 'WSN' named entity 'Signs of disease' named entity 'oseltamivir' named entity 'weight loss' named entity 'monotherapy' named entity 'infection' named entity 'prophylactic' named entity 'WSN' named entity 'control group' named entity 'antibody'

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