About: Efficacy of glucocorticoids for the treatment of macrolide refractory mycoplasma pneumonia in children: meta-analysis of randomized controlled trials

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Efficacy of glucocorticoids for the treatment of macrolide refractory mycoplasma pneumonia in children: meta-analysis of randomized controlled trials Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Efficacy of glucocorticoids for the treatment of macrolide refractory mycoplasma pneumonia in children: meta-analysis of randomized controlled trials
Creator	Yang, Hyeon-Jong Kim, Hyun Choi, Miyoung Li, Donghe Choi, Yun Kim, Soo Lee, Kyung Lee, Yong Seo, Ju Sol, In
Source	Medline; PMC
abstract	BACKGROUND: Mycoplasma pneumoniae is one of the most common pathogens causing community acquired pneumonia in children. Although the rate of macrolide-refractory Mycoplasma pneumoniae (MRMP) has increased, systemic glucocorticoids as a treatment option has not been validated yet. The purpose of this study was to assess the efficacy of glucocorticoids add-on in the treatment of MRMP in children through systematic review and meta-analysis. METHODS: Data sources A systematic literature search was conducted using ten electronic bibliographic databases including English, Korean, Chinese and Japanese languages, up to March 8, 2018. Study selection The study was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist and selected randomized control trials which compared the efficacy of glucocorticoids add-on to macrolide in the treatment of MRMP in children. Data extraction Two independent reviewers extracted: primary outcomes as hospital days, fever duration, and change in C-reactive protein (CRP) and main analysis was performed through meta-analysis with random effects model. RESULTS: Twenty-four unique randomized controlled trials met the inclusion criteria. The mean length of hospital stay in glucocorticoids treatment group was significantly shorter than that in conventional macrolide-treatment group (Weighted mean difference (WMD) = − 4.03 days). The mean length of fever duration was significantly shorter in the glucocorticoid treatment group in comparison with the conventional treatment group (WMD = -3.32 days). Level of CRP after treatment was significantly lower in the glucocorticoid treatment group than that in the conventional treatment group (WMD = -16.03). Sensitivity analysis and subgroup analysis showed no significant improvement in heterogeneity. As limitations of the study, most of the studies included were from a single country and we were unable to control for heterogeneity across interventions, lack of standardized measures, and different time points of assessments across studies. CONCLUSIONS: Glucocorticoid add-on treatment for MRMP can significantly shorten the duration of fever and hospital stay and decrease the level of CRP. These results should be confirmed by adequately powered studies in the future.
has issue date	2019-12-18(xsd:dateTime)
bibo:doi	10.1186/s12890-019-0990-8
bibo:pmid	31852460
has license	cc-by
sha1sum (hex)	9a8ffdaee3a800f0e6867b63ffd109e9c30621b8
schema:url	https://doi.org/10.1186/s12890-019-0990-8
resource representing a document's title	Efficacy of glucocorticoids for the treatment of macrolide refractory mycoplasma pneumonia in children: meta-analysis of randomized controlled trials
has PubMed Central identifier	PMC6921474
has PubMed identifier	31852460
schema:publication	BMC Pulm Med
resource representing a document's body	covid:9a8ffdaee3a800f0e6867b63ffd109e9c30621b8#body_text
is schema:about of	named entity 'Mycoplasma pneumoniae' named entity 'causing' named entity 'bibliographic databases' named entity 'conducted' named entity 'ANALYSIS' named entity 'MARCH' named entity 'BACKGROUND' named entity 'SYSTEMATIC REVIEW' named entity 'INCLUDING' named entity '2018' named entity 'ASSESS' named entity 'CHILDREN' named entity 'DATA SOURCES' named entity 'KOREAN' named entity 'DATABASES' named entity 'CHINESE' named entity 'UP TO' named entity 'MYCOPLASMA PNEUMONIAE' named entity 'COMMON' named entity 'SYSTEMIC' named entity 'EFFICACY' named entity 'PATHOGENS' named entity 'LANGUAGES' named entity 'USING' named entity 'META' named entity 'MACROLIDE' named entity 'MACROLIDE' named entity 'LITERATURE SEARCH' named entity 'REFRACTORY' named entity 'COMMUNITY ACQUIRED PNEUMONIA' named entity 'EFFICACY' named entity 'TREATMENT' named entity 'MYCOPLASMA PNEUMONIA' named entity 'GLUCOCORTICOIDS' named entity 'TREATMENT OPTION' named entity 'ELECTRONIC' named entity 'JAPANESE' named entity 'STUDY' named entity 'TREATMENT' named entity 'META-ANALYSIS' named entity 'CAUSING' named entity 'ONE OF' named entity 'REFRACTORY' named entity 'CHILDREN' named entity 'RANDOMIZED CONTROLLED TRIALS' named entity 'RATE' named entity 'PURPOSE' named entity 'METHODS' named entity 'VALIDATED' named entity 'ENGLISH' named entity 'GLUCOCORTICOIDS' named entity 'INCREASED' named entity 'systematic review' named entity 'glucocorticoids' named entity 'meta-analysis' named entity 'Mycoplasma pneumoniae' named entity 'bibliographic databases' named entity 'community acquired pneumonia' named entity 'Data sources' named entity 'macrolide' named entity 'refractory' named entity 'macrolide' named entity 'meta-analysis' named entity 'CRP' named entity 'selective reporting' named entity 'electronic search' named entity 'China' named entity 'glucocorticoids' named entity 'bronchitis' named entity 'WMD' named entity 'antibiotics' named entity 'lactate dehydrogenase'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software