About: Zebrafish TRIM25 Promotes Innate Immune Response to RGNNV Infection by Targeting 2CARD and RD Regions of RIG-I for K63-Linked Ubiquitination

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About: Zebrafish TRIM25 Promotes Innate Immune Response to RGNNV Infection by Targeting 2CARD and RD Regions of RIG-I for K63-Linked Ubiquitination Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Zebrafish TRIM25 Promotes Innate Immune Response to RGNNV Infection by Targeting 2CARD and RD Regions of RIG-I for K63-Linked Ubiquitination
Creator	Liu, Wei Jia, Peng Zhang, Yong-An Jia, Kuntong Jin, Yilin Xiang, Yangxi Yi, Meisheng Zhang, Wanwan Xiang, Zhang
Source	Medline; PMC
abstract	RIG-I-like receptors (RLRs) play important roles in response to virus infection by regulating host innate immune signaling pathways. Meanwhile, the RLR signaling pathway is also tightly regulated by host and virus to achieve the immune homeostasis between antiviral responses and virus survival. Here, we found that zebrafish TRIM25 (zbTRIM25) functioned as a positive regulator of RLR signaling pathway during red spotted grouper nervous necrosis virus (RGNNV) infection. Post-RGNNV infection, zbTRIM25 expression was obviously inhibited and ectopic expression of zbTRIM25 led to enhanced expression of RLR signaling pathway-related genes. Overexpression and knockdown analysis revealed that zbTRIM25 promoted zebrafish RIG-I (zbRIG-I)-mediated IFN signaling and inhibited RGNNV replication. Mechanistically, zbTRIM25 bound to zbRIG-I; in particular, the SPRY domain of zbTRIM25 interacted with the tandem caspase activation and recruitment domains (2CARD) and repressor domain (RD) regions of zbRIG-I. zbTRIM25 promoted the K63 polyubiquitination of 2CARD and RD regions of zbRIG-I. Furthermore, zbTRIM25-mediated zbRIG-I activation of IFN production was enhanced by K63-linked ubiquitin, indicating that zbTRIM25-mediated zbRIG-I polyubiquitination was essential for RIG-I-triggered IFN induction. In conclusion, these findings reveal a novel mechanism that zbTRIM25 positively regulates the innate immune response by targeting and promoting the K63-linked polyubiquitination of zbRIG-I.
has issue date	2019-12-03(xsd:dateTime)
bibo:doi	10.3389/fimmu.2019.02805
bibo:pmid	31849979
has license	cc-by
sha1sum (hex)	9a87a6bf36af7342e6bbb2e13da6181a8c0bab27
schema:url	https://doi.org/10.3389/fimmu.2019.02805
resource representing a document's title	Zebrafish TRIM25 Promotes Innate Immune Response to RGNNV Infection by Targeting 2CARD and RD Regions of RIG-I for K63-Linked Ubiquitination
has PubMed Central identifier	PMC6901795
has PubMed identifier	31849979
schema:publication	Front Immunol
resource representing a document's body	covid:9a87a6bf36af7342e6bbb2e13da6181a8c0bab27#body_text
is schema:about of	named entity 'targeting' named entity 'regulating' named entity 'RLR' named entity 'grouper' named entity 'genes' named entity 'activation' named entity 'homeostasis' named entity 'linked' named entity 'zebrafish' named entity 'ESSENTIAL' named entity 'RESPONSE TO VIRUS' named entity 'RECRUITMENT' named entity 'VIRUS INFECTION' named entity 'RED' named entity 'INDICATING' named entity 'ECTOPIC EXPRESSION' named entity 'INDUCTION' named entity 'TARGETING' named entity 'FOUND' named entity 'EXPRESSION' named entity 'PROMOTING' named entity 'ACTIVATION' named entity 'REGIONS' named entity 'RESPONSES' named entity 'REGULATING' named entity 'RIG-I' named entity 'ANTIVIRAL' named entity 'MEDIATED' named entity 'IMMUNE' named entity 'POST' named entity 'INTERACTED' named entity 'SIGNALING PATHWAYS' named entity 'POLYUBIQUITINATION' named entity 'RLR SIGNALING PATHWAY' named entity 'VIRUS' named entity 'K63' named entity 'OVEREXPRESSION' named entity 'PARTICULAR' named entity 'INNATE IMMUNE RESPONSE' named entity 'PLAY' named entity 'REGULATED' named entity 'RELATED' named entity 'SURVIVAL' named entity 'HERE' named entity 'ANALYSIS' named entity 'NOVEL' named entity 'LED' named entity 'CASPASE ACTIVATION' named entity 'MECHANISM' named entity 'SIGNALING' named entity 'REPRESSOR' named entity 'RECEPTORS' covid:arg/9a87a6bf36af7342e6bbb2e13da6181a8c0bab27 named entity 'TANDEM' named entity 'IMPORTANT' named entity 'THESE' named entity 'CITATION' named entity 'ZEBRAFISH' named entity 'PRODUCTION' named entity 'HOST' named entity 'RIG-I' named entity 'ZEBRAFISH' named entity 'TARGETING' named entity 'K63' named entity 'TRIM25' named entity 'RESPONSE TO' named entity 'INNATE IMMUNE RESPONSE' named entity 'UBIQUITINATION' named entity 'REPLICATION' named entity 'FINDINGS' named entity 'INFECTION' named entity 'INHIBITED' named entity 'ENHANCED'

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