About: Preparation, characterization and preliminary in vivo studies of inactivated SARS-CoV vaccine

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About: Preparation, characterization and preliminary in vivo studies of inactivated SARS-CoV vaccine Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Preparation, characterization and preliminary in vivo studies of inactivated SARS-CoV vaccine
Creator	Wang, Jian Qingyu, Zhu Tang, Lin Zhang, Xumin Wang, Caiping Chang Guohui, Cheng Xiaojie, Huiying, Shi Jun, Y Man, Y Qin Ede, Shuangli, L Xishu, Chen Ze, Chen Zhifen, Ding
source	Medline; PMC
abstract	A large quantity of SARS-CoV virus was proliferated in Vero cells, inactivated with β-propiolactone, then purified by Sepharose 4FF column chromatography to prepare inactivated vaccine. The vaccine was identified by Western blot, mass spectrographic analysis, ELISA and electron microscopy. The vaccine with or without aluminum hydroxide adjuvant was inoculated into female BALB/c mice at different dosages. The result showed that the antibodies to SARS-CoV were induced in the mice. The antibody levels induced by the vaccine with aluminum hydroxide were higher than those without aluminum hydroxide.
has issue date	2003-01-01(xsd:dateTime)
bibo:doi	10.1360/03wc464
bibo:pmid	32214708
has license	no-cc
sha1sum (hex)	9a6631817877e5924183cd6e4c88ac6aade44978
schema:url	https://doi.org/10.1360/03wc464
resource representing a document's title	Preparation, characterization and preliminary in vivo studies of inactivated SARS-CoV vaccine
has PubMed Central identifier	PMC7088751
has PubMed identifier	32214708
schema:publication	Chin Sci Bull
resource representing a document's body	covid:9a6631817877e5924183cd6e4c88ac6aade44978#body_text
is schema:about of	named entity 'MASS' named entity 'BALB' named entity 'ELECTRON MICROSCOPY' named entity 'PURIFIED' named entity 'ADJUVANT' named entity 'levels' named entity 'The' named entity 'antibody' named entity 'vaccine' named entity 'INACTIVATED' named entity 'RESULT' named entity 'SARS-COV' named entity 'ANTIBODIES' named entity 'IDENTIFIED BY' named entity 'ANTIBODY' named entity 'COLUMN CHROMATOGRAPHY' named entity 'WESTERN BLOT' named entity 'MICE' named entity 'ELISA' named entity 'PRELIMINARY' named entity 'CHARACTERIZATION' named entity 'FEMALE' named entity 'INACTIVATED' named entity 'ALUMINUM HYDROXIDE' named entity 'QUANTITY' named entity 'VIRUS' named entity 'STUD' named entity 'IN VIVO' named entity 'PREPARATION' named entity 'IES' named entity 'ANALYSIS' named entity 'VACCINE' named entity 'PROPIOLACTONE' named entity 'HIGHER' named entity 'VERO CELLS' named entity 'INDUCED' named entity 'LARGE' named entity 'SEPHAROSE' named entity 'LEVELS' named entity 'TO PREPARE' named entity 'DIFFERENT' named entity 'INACTIVATED VACCINE' named entity 'DOSAGES' covid:arg/9a6631817877e5924183cd6e4c88ac6aade44978 named entity 'induced' named entity 'Vero' named entity 'cells' named entity 'aluminum hydroxide' named entity 'vivo' named entity 'antibodies' named entity 'aluminum hydroxide' named entity 'mice' named entity 'inoculated' named entity 'SARS-CoV' named entity 'adjuvant' named entity 'vaccine' named entity 'SARS-CoV' named entity 'Laboratory Animal' named entity 'antibody titer' named entity 'serum' named entity 'vaccine' named entity 'subunit vaccine' named entity 'Labsystems' named entity 'epidemic' named entity 'antibody' named entity 'SARS' named entity 'influenza vaccine'

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