About: Molecular analysis of sarcoidosis lymph nodes for microorganisms: a case

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About: Molecular analysis of sarcoidosis lymph nodes for microorganisms: a case–control study with clinical correlates Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Molecular analysis of sarcoidosis lymph nodes for microorganisms: a case–control study with clinical correlates
Creator	Smith, Prudence Prentice, Jennifer Robinson, Lary Sandin, Ramon Sengupta, Dhruba
Source	Medline; PMC
abstract	INTRODUCTION: Sarcoidosis is an incurable, chronic granulomatous disease primarily involving the lungs and lymph nodes of unknown aetiology, treated with non-specific anti-inflammatory/immunosuppressive drugs. Persistently symptomatic patients worsen with a disabling, potentially fatal clinical course. To determine a possible infectious cause, we correlated in a case-control study the clinical information with the presence of bacterial DNA in sarcoidosis mediastinal lymph nodes compared with control lymph nodes resected during cancer surgery. METHODS: We retrospectively studied formalin-fixed, paraffin-embedded, mediastinal lymph nodes from 30 patients with sarcoidosis and 30 control patients with lung cancer. Nucleic acids were extracted from nodes, evaluated by ribosomal RNA PCR for bacterial 16S ribosomal DNA and the results were sequenced and compared with a bacterial sequence library. Clinical information was correlated. RESULTS: 11/30 (36.7%) of lymph nodes from patients with sarcoidosis had detectable bacterial DNA, significantly more than control patient lymph nodes (2/30, 6.7%), p=0.00516. At presentation, 19/30 (63.3%) patients with sarcoidosis were symptomatic including all patients with detectable bacterial DNA. Radiographically, there were 18 stage I and 12 stage II patients. All stage II patients were symptomatic and 75% had PCR-detectable bacteria. After a mean follow-up of 52.8±32.8 months, all patients with PCR-detectable bacteria in this series were persistently symptomatic requiring treatment. DISCUSSION: 36.6% of patients with sarcoidosis had detectable bacterial DNA on presentation, all of these patients were quite symptomatic and most were radiographically advanced stage II. These findings suggest that bacterial DNA-positive, symptomatic patients have more aggressive sarcoidosis that persists long term and might benefit from antimicrobial treatment directed against this presumed chronic granulomatous infection.
has issue date	2013-12-21(xsd:dateTime)
bibo:doi	10.1136/bmjopen-2013-004065
bibo:pmid	24366580
has license	cc-by-nc
sha1sum (hex)	9a494f17a77c5920be077ac59abc8a7546f4ee67
schema:url	https://doi.org/10.1136/bmjopen-2013-004065
resource representing a document's title	Molecular analysis of sarcoidosis lymph nodes for microorganisms: a case–control study with clinical correlates
has PubMed Central identifier	PMC3884606
has PubMed identifier	24366580
schema:publication	BMJ Open
resource representing a document's body	covid:9a494f17a77c5920be077ac59abc8a7546f4ee67#body_text
is schema:about of	named entity 'CLINICAL' named entity 'LYMPH NODES' named entity 'CASE-CONTROL STUDY' named entity 'MOLECULAR ANALYSIS' named entity 'MICROORGANISMS' named entity 'SARCOIDOSIS' named entity 'microorganisms' named entity 'microorganisms' named entity 'case-control study' named entity 'long-term' named entity 'tuberculosis' named entity 'Open Access' named entity 'electronic medical record' named entity 'antibacterial' named entity 'sarcoidosis' named entity 'tumour necrosis factor-α' named entity 'sample size' named entity 'lymph nodes' named entity 'granulomatous' named entity 'PCR' named entity 'gastroenterologists' named entity 'organism' named entity 'immunological response' named entity 'sarcoidosis' named entity 'stage 3' named entity 'xylene' named entity 'diarrhoea' named entity 'Lung nodules' named entity 'follow-up' named entity 'mediastinal' named entity 'radiographic' named entity 'lymph nodes' named entity 'sarcoidosis' named entity 'false-positive' named entity 'histological' named entity 'atelectasis' named entity 'control patients' named entity 'cell-wall' named entity 'sarcoidosis' named entity 'lesion' named entity 'Mycobacterium leprae' named entity 'sarcoidosis' named entity 'clinical presentation' named entity 'primers' named entity 'tuberculosis' named entity 'isoniazid' named entity 'lymph nodes' named entity 'cellular immune response' named entity 'Open Access' named entity 'epithelioid' named entity 'sarcoidosis' named entity 'mucous membrane' named entity 'Propionibacterium acnes' named entity 'uterine' named entity 'adrenal' named entity 'immune reaction' named entity 'immune response' named entity 'Crohn's disease' named entity 'lymph nodes' named entity 'India' named entity 'microorganism' named entity 'beryllium' named entity 'sequenced' named entity 'Johne's disease' named entity 'follow-up' named entity 'Microbiology' named entity 'granulomatous reaction' named entity 'Gram-negative' named entity 'principal investigator' named entity 'tonsil' named entity 'adenopathy' named entity 'bronchospasm' named entity 'adenopathy' named entity 'Mycobacterium tuberculosis' named entity 'sarcoidosis' named entity 'cough' named entity 'sarcoidosis'

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