About: Dissemination of Internal Ribosomal Entry Sites (IRES) Between Viruses by Horizontal Gene Transfer

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Dissemination of Internal Ribosomal Entry Sites (IRES) Between Viruses by Horizontal Gene Transfer
Creator	Hellen, Christopher Pestova, Tatyana Arhab, Yani Bulakhov, Alexander
topic	covid:99a19061d6f204c08bfefd6a93dac35e47489a17#this
Source	Medline; PMC
abstract	Members of Picornaviridae and of the Hepacivirus, Pegivirus and Pestivirus genera of Flaviviridae all contain an internal ribosomal entry site (IRES) in the 5′-untranslated region (5′UTR) of their genomes. Each class of IRES has a conserved structure and promotes 5′-end-independent initiation of translation by a different mechanism. Picornavirus 5′UTRs, including the IRES, evolve independently of other parts of the genome and can move between genomes, most commonly by intratypic recombination. We review accumulating evidence that IRESs are genetic entities that can also move between members of different genera and even between families. Type IV IRESs, first identified in the Hepacivirus genus, have subsequently been identified in over 25 genera of Picornaviridae, juxtaposed against diverse coding sequences. In several genera, members have either type IV IRES or an IRES of type I, II or III. Similarly, in the genus Pegivirus, members contain either a type IV IRES or an unrelated type; both classes of IRES also occur in members of the genus Hepacivirus. IRESs utilize different mechanisms, have different factor requirements and contain determinants of viral growth, pathogenesis and cell type specificity. Their dissemination between viruses by horizontal gene transfer has unexpectedly emerged as an important facet of viral evolution.
has issue date	2020-06-04(xsd:dateTime)
bibo:doi	10.3390/v12060612
bibo:pmid	32512856
has license	cc-by
sha1sum (hex)	99a19061d6f204c08bfefd6a93dac35e47489a17
schema:url	https://doi.org/10.3390/v12060612
resource representing a document's title	Dissemination of Internal Ribosomal Entry Sites (IRES) Between Viruses by Horizontal Gene Transfer
has PubMed Central identifier	PMC7354566
has PubMed identifier	32512856
schema:publication	Viruses
resource representing a document's body	covid:99a19061d6f204c08bfefd6a93dac35e47489a17#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/99a19061d6f204c08bfefd6a93dac35e47489a17
is schema:about of	named entity 'conserved' named entity 'recombination' named entity 'genera' named entity 'Picornaviridae' named entity 'UTR' named entity 'ribosomal' named entity 'independently' named entity 'Horizontal' named entity 'HORIZONTAL GENE TRANSFER' named entity 'HAVE' named entity 'IMPORTANT' named entity 'PEGIVIRUS' named entity 'CONSERVED' named entity 'PATHOGENESIS' named entity 'TRANSLATION' named entity 'VIRAL EVOLUTION' named entity 'EVOLVE' named entity 'INCLUDING' named entity 'DIVERSE' named entity 'IRESs' named entity 'move' named entity 'identified' named entity 'evolve' named entity 'genera' named entity 'Hepacivirus' named entity 'Hepacivirus' named entity 'genus' named entity 'pathogenesis' named entity 'Flaviviridae' named entity 'genomes' named entity 'ribosomal' named entity 'genus' named entity 'untranslated region' named entity 'Picornaviridae' named entity 'sequence homology' named entity 'metagenomic data' named entity 'Aphthovirus' named entity 'IRESs' named entity 'IRESs' named entity '80S ribosome' named entity 'Bat' named entity 'eIF2' named entity 'IRESs' named entity 'chimeric' named entity 'sequence homology' named entity '5'UTRs' named entity 'classical swine fever virus' named entity 'cap-binding' named entity 'Mosavirus' named entity 'Pestivirus' named entity 'innate immune responses' named entity 'repressors' named entity 'recombination' named entity 'CrPV' named entity 'blue line' named entity 'IRES' named entity 'Wuhan' named entity 'pegivirus' named entity 'stemloop' named entity 'eIF4F' named entity 'covariation' named entity 'Dicistroviridae' named entity 'triplet' named entity 'Sapelovirus' named entity 'initiation codon' named entity 'pathogenesis' named entity 'pestivirus' named entity 'Sequence identity' named entity 'Taura syndrome' named entity 'IRESs' named entity 'genomes' named entity 'recombination' named entity 'skink' named entity 'heritable' named entity 'sequence identity' named entity 'proximal'

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