About: Gendered effects on inflammation reaction and outcome of COVID‐19 patients in Wuhan

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Gendered effects on inflammation reaction and outcome of COVID‐19 patients in Wuhan
Creator	Wang, Ke Xu, Shuyun Zhou, Min Li, Xiaochen Shi, Jing Zhou, Ying Tao, Yu Wu, Bo Qin, Lu Xie, Liu, ; Zhang, ; Xie, Min Cheng, Chongsheng Yu, Muqing Yue, Junqing Yang, Zhenyu
Source	Medline; PMC
abstract	BACKGROUND: The rapid outbreak of coronavirus disease 2019 (COVID‐19) has turned into a public health emergency of international concern. Epidemiological research showed that gender was associated with the severity of COVID‐19, but the underlying mechanism of gender predisposition remains poorly understood. We aim to study the gendered differences in inflammation reaction, and the association with severity and mortality of COVID‐19. METHODS: In this retrospective study, we enrolled 548 COVID‐19 inpatients from Tongji Hospital from January 26 to February 5, 2020, and followed up to March 3, 2020. Epidemiological, demographic and clinical features, and inflammatory indexes were collected and compared between males and females. Cox proportional hazard regression model was applied to identify gendered effect on mortality of COVID‐19 after adjusting age, comorbidity and smoking history. Multiple linear regression method was used to explore the influence of sex on inflammation reaction. RESULTS: Males had higher mortality than females did (22.2% vs. 10.4%), with the HR of 1.923 (95% CI, 1.181‐3.130); elder age and comorbidity were significantly associated with decease of COVID‐19 patients. Excess inflammation reaction was related to severity of COVID‐19. Male patients had greater inflammation reaction, with higher levels of IL‐10, TNF‐α, LDH, ferritin and hsCRP, but lower lymphocyte count than females adjusted by age and comorbidity. CONCLUSIONS: Gender, age, and comorbidity are critical risk factors for mortality of COVID‐19. Excess innate immunity and proinflammation activity, and deficiency in adaptive immunity response promote males especially elder males to develop cytokine storm, causing potential ARDS, multiple organ failure and decease. This article is protected by copyright. All rights reserved.
has issue date	2020-06-04(xsd:dateTime)
bibo:doi	10.1002/jmv.26137
bibo:pmid	32497297
has license	no-cc
sha1sum (hex)	99243ed977ec57f29798fee3e4cb5a748a7bb56c
schema:url	https://doi.org/10.1002/jmv.26137
resource representing a document's title	Gendered effects on inflammation reaction and outcome of COVID‐19 patients in Wuhan
has PubMed Central identifier	PMC7300463
has PubMed identifier	32497297
schema:publication	J Med Virol
resource representing a document's body	covid:99243ed977ec57f29798fee3e4cb5a748a7bb56c#body_text
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