About: Autopsy analyses in acute exacerbation of idiopathic pulmonary fibrosis

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About: Autopsy analyses in acute exacerbation of idiopathic pulmonary fibrosis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Autopsy analyses in acute exacerbation of idiopathic pulmonary fibrosis
Creator	Mukae, Hiroshi Ishii, Hiroshi Kohno, Shigeru Harada, Tatsuhiko Imanaga, Tomotoshi Ishimatsu, Yuji Ishimoto, Hiroshi Kadota, Jun-Ichi Kushima, Hisako Matsumoto, Nobuhiro Naito, Keisuke Nakazato, Masamitsu Oda, Keishi Watanabe, Kentaro Yamada, Sohsuke Yatera, Kazuhiro
Source	PMC
abstract	BACKGROUND: Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is associated with high mortality. However, few studies have so far reviewed analyses of autopsy findings in patients with AE-IPF. METHODS: We retrospectively reviewed 52 consecutive patients with AE-IPF who underwent autopsies at five university hospitals and one municipal hospital between 1999 and 2013. The following variables were abstracted from the medical records: demographic and clinical data, autopsy findings and complications during the clinical course until death. RESULTS: The median age at autopsy was 71 years (range 47–86 years), and the subjects included 38 (73.1%) males. High-dose corticosteroid therapy was initiated in 45 (86.5%) patients after AE-IPF. The underling fibrotic lesion was classified as having the usual interstitial pneumonia (UIP) pattern in all cases. Furthermore, 41 (78.8%) patients had diffuse alveolar damage (DAD), 15 (28.8%) exhibited pulmonary hemorrhage, nine (17.3%) developed pulmonary thromboembolism and six (11.5%) were diagnosed with lung carcinoma. In addition, six (11.5%) patients developed pneumothorax prior to death and 26 (53.1%) developed diabetes that required insulin treatment after the administration of high-dose corticosteroid therapy. In addition, 15 (28.8%) patients presented with bronchopneumonia during their clinical course and/or until death, including fungal (seven, 13.5%), cytomegalovirus (six, 11.5%) and bacterial (five, 9.6%) infections. CONCLUSIONS: The pathological findings in patients with AE-IPF represent not only DAD, but also a variety of pathological conditions. Therefore, making a diagnosis of AE-IPF is often difficult, and the use of cautious diagnostic approaches is required for appropriate treatment.
has issue date	2014-09-01(xsd:dateTime)
bibo:doi	10.1186/s12931-014-0109-y
bibo:pmid	25176016
has license	cc-by
sha1sum (hex)	990f222ee5a26b7b1c09cfff878a1c987efd44b3
schema:url	https://doi.org/10.1186/s12931-014-0109-y
resource representing a document's title	Autopsy analyses in acute exacerbation of idiopathic pulmonary fibrosis
has PubMed Central identifier	PMC4243719
has PubMed identifier	25176016
schema:publication	Respir Res
resource representing a document's body	covid:990f222ee5a26b7b1c09cfff878a1c987efd44b3#body_text
is schema:about of	named entity 'ASSOCIATED WITH' named entity 'MORTALITY' covid:arg/990f222ee5a26b7b1c09cfff878a1c987efd44b3 named entity 'Acute' named entity 'Acute exacerbation' named entity 'pulmonary hemorrhage' named entity 'tetrahydrochloride' named entity 'Alveolar' named entity 'pulmonary hypertension' named entity 'pulmonary embolism' named entity 'hypoxemia' named entity 'IPF' named entity 'DAD' named entity 'diagnostic criteria' named entity 'autopsy' named entity 'alveoli' named entity 'DAD' named entity 'hemorrhage' named entity 'hypoxic' named entity 'Pneumocystis pneumonia' named entity 'staining' named entity 'aspergillosis' named entity 'collagen' named entity 'HRCT' named entity 'postmortem' named entity 'DAD' named entity 'abscess' named entity 'pulmonary infection' named entity 'lungs' named entity 'IPF' named entity 'acute respiratory distress syndrome' named entity 'UIP' named entity 'lung carcinoma' named entity 'pneumothorax' named entity 'staining' named entity 'immunosuppressive agents' named entity 'IPF' named entity 'DAD' named entity 'cytomegalovirus' named entity 'corticosteroid therapy' named entity 'lung adenocarcinoma' named entity 'pulmonary embolism' named entity 'hypoxemia' named entity 'corticosteroid therapy' named entity 'lungs' named entity 'pulmonary infections' named entity 'histopathological' named entity 'autopsy' named entity 'type II' named entity 'interstitial pneumonia' named entity 'IPF' named entity 'fibrin' named entity 'peroxidase' named entity 'bronchiolitis obliterans organizing pneumonia' named entity 'infectious diseases' named entity 'Pulmonary hemorrhage' named entity 'respiratory failure' named entity 'infectious diseases' named entity 'pulmonary hypertension' named entity 'Grocott's methenamine silver stain' named entity 'laboratory tests' named entity 'IPF' named entity 'DAD' named entity 'medical records' named entity 'mechanical ventilation' named entity 'Gram staining'

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