About: Mesodynamics in the SARS nucleocapsid measured by NMR field cycling

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mesodynamics in the SARS nucleocapsid measured by NMR field cycling
Creator	Kern, Dorothee Ae, Alfred Ae, Labeikovsky Ae, Ming Clarkson Ae, Michael Eisenmesser, Elan Wladimir, A
Source	Medline; PMC
abstract	Protein motions on all timescales faster than molecular tumbling are encoded in the spectral density. The dissection of complex protein dynamics is typically performed using relaxation rates determined at high and ultra-high field. Here we expand this range of the spectral density to low fields through field cycling using the nucleocapsid protein of the SARS coronavirus as a model system. The field-cycling approach enables site-specific measurements of R (1) at low fields with the sensitivity and resolution of a high-field magnet. These data, together with high-field relaxation and heteronuclear NOE, provide evidence for correlated rigid-body motions of the entire β-hairpin, and corresponding motions of adjacent loops with a time constant of 0.8 ns (mesodynamics). MD simulations substantiate these findings and provide direct verification of the time scale and collective nature of these motions.
has issue date	2009-07-30(xsd:dateTime)
bibo:doi	10.1007/s10858-009-9347-6
bibo:pmid	19641854
has license	cc-by-nc
sha1sum (hex)	98e85066186167e53509cadef5d5389f2087da2e
schema:url	https://doi.org/10.1007/s10858-009-9347-6
resource representing a document's title	Mesodynamics in the SARS nucleocapsid measured by NMR field cycling
has PubMed Central identifier	PMC2728245
has PubMed identifier	19641854
schema:publication	J Biomol NMR
resource representing a document's body	covid:98e85066186167e53509cadef5d5389f2087da2e#body_text
is schema:about of	named entity 'ENABLES' named entity 'SENSITIVITY' named entity 'COLLECTIVE' named entity 'SITE' named entity 'LOW' named entity 'RESOLUTION' named entity 'CYCLING' named entity 'DISSECTION' named entity 'MD SIMULATIONS' named entity 'PROVIDE' named entity 'SPECIFIC' named entity 'MAGNET' named entity 'LOOPS' named entity 'MODEL SYSTEM' named entity 'COMPLEX PROTEIN' named entity 'NATURE' named entity 'TUMBLING' named entity 'DATA' named entity 'DIRECT' named entity 'PROTEIN DYNAMICS' named entity 'RIGID' named entity 'RELAXATION' named entity 'NUCLEOCAPSID' named entity 'SARS' covid:arg/98e85066186167e53509cadef5d5389f2087da2e named entity 'EXPAND' named entity 'PERFORMED' named entity 'ENCODED' named entity 'NOE' named entity 'SARS CORONAVIRUS AS' named entity 'CORRELATED' named entity 'PROTEIN ' named entity 'FIELD' named entity 'BODY' named entity 'CYCLING' named entity 'NMR' named entity 'ADJACENT' named entity 'APPROACH' named entity 'SPECTRAL' named entity 'SCALE' named entity 'USING' named entity 'ENTIRE' named entity 'DETERMINED' named entity 'MOTIONS' named entity 'HERE' named entity 'MEASURED' named entity 'TIME' named entity 'MOLECULAR' named entity 'MEASUREMENTS' named entity 'EVIDENCE FOR' named entity 'FIELD' named entity 'FINDINGS' named entity 'TIME CONSTANT' named entity 'RATES' named entity 'HIGH' named entity '0.8' named entity 'FASTER' named entity 'NUCLEOCAPSID PROTEIN' named entity 'VERIFICATION' named entity 'RANGE' named entity 'DENSITY' named entity 'THESE' named entity 'Protein' named entity 'spectral density' named entity 'nucleocapsid' named entity 'SARS' named entity 'correlation time' named entity 'NaCl' named entity 'correlation time' named entity 'protein' named entity 'free theory' named entity 'BIC' named entity 'Lipari' named entity 'protein' named entity 'protein'

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