About: Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early prognostic marker for severe COVID-19

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About: Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early prognostic marker for severe COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early prognostic marker for severe COVID-19
Creator	Rötzschke, Olaf Leo, Yee-Sin Lee, Bernett Larbi, Anis Carissimo, Guillaume Chan, Hao Lye, David Ng, Lisa Young, Barnaby Chee, Rhonda Sin-Ling Kumar Andiappan, Anand Lee, Yi-Pin Naqiah Amrun, Siti Renia, Laurent Chan, Stephrene Fong, Siew-Wai Xu, Weili Fan, Eugene How, Wilson Kim-Wah, Nicholas Kwok, Immanuel Ng, Guan Puan, Kia Yazid Abdad, Mohammad
Source	BioRxiv
abstract	SARS-CoV-2 is the novel coronavirus responsible for the current COVID-19 pandemic. Severe complications are observed only in a small proportion of infected patients but the cellular mechanisms underlying this progression are still unknown. Comprehensive flow cytometry of whole blood samples from 54 COVID-19 patients revealed a dramatic increase in the number of immature neutrophils. This increase strongly correlated with disease severity and was associated with elevated IL-6 and IP-10 levels, two key players in the cytokine storm. The most pronounced decrease in cell counts was observed for CD8 T-cells and VD2 γδ T-cells, which both exhibited increased differentiation and activation. ROC analysis revealed that the count ratio of immature neutrophils to CD8 or VD2 T-cells predicts pneumonia onset (0.9071) as well as hypoxia onset (0.8908) with high sensitivity and specificity. It would thus be a useful prognostic marker for preventive patient management and improved healthcare resource management.
has issue date	2020-06-12(xsd:dateTime)
bibo:doi	10.1101/2020.06.11.147389
has license	biorxiv
sha1sum (hex)	98a6eaa15aa822ba73f075495e680eb9a597834d
schema:url	https://doi.org/10.1101/2020.06.11.147389
resource representing a document's title	Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early prognostic marker for severe COVID-19
schema:publication	bioRxiv
resource representing a document's body	covid:98a6eaa15aa822ba73f075495e680eb9a597834d#body_text
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