About: Structural insights into RNA recognition and activation of RIG-I-like receptors

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Structural insights into RNA recognition and activation of RIG-I-like receptors
Creator	Leung, Daisy Amarasinghe, Gaya Puglisi, Jody Williamson, Jamie
Source	Elsevier; Medline; PMC
abstract	RIG-I like receptors (RLR) that recognize non-self RNA play critical roles in activating host innate immune pathways in response to viral infections. Not surprisingly, RLRs and their associated signaling networks are also targeted by numerous antagonists that facilitate viral pathogenesis. Although the role of RLRs in orchestrating antiviral signaling has been recognized for some time, our knowledge of the complex regulatory mechanisms that control signaling through these key molecules is incomplete. A series of recent structural studies shed new light into the structural basis for dsRNA recognition and activation of RLRs. Collectively, these studies suggest that the repression of RLRs is facilitated by a cis element that makes multiple contacts with domains within the helicase and that RNA binding initiated by the C-terminal RNA binding domain is important for ATP hydrolysis and release of the CARD domain containing signaling module from the repressed conformation. These studies also highlight potential differences between RIG-I and MDA5, two RLR members. Together with previous studies, these new results bring us a step closer to uncovering the complex regulatory process of a key protein that protects host cells from invading pathogens.
has issue date	2012-06-01(xsd:dateTime)
bibo:doi	10.1016/j.sbi.2012.03.011
bibo:pmid	22560447
has license	green-oa
sha1sum (hex)	988378806c173a9d0cc4c2901e5c4c60d24328dc
schema:url	https://doi.org/10.1016/j.sbi.2012.03.011
resource representing a document's title	Structural insights into RNA recognition and activation of RIG-I-like receptors
has PubMed Central identifier	PMC3383332
has PubMed identifier	22560447
schema:publication	Current Opinion in Structural Biology
resource representing a document's body	covid:988378806c173a9d0cc4c2901e5c4c60d24328dc#body_text
is schema:about of	named entity 'STRUCTURAL' named entity 'LIKE' named entity 'series' named entity 'roles' named entity 'RECOGNITION' named entity 'SUGGEST' named entity 'REGULATORY PROCESS' named entity 'CIS ELEMENT' named entity 'MECHANISMS' named entity 'CRITICAL' named entity 'KEY' named entity 'RECOGNITION' named entity 'PATHWAYS' named entity 'SIGNALING' named entity 'RESPONSE TO' named entity 'ANTIVIRAL' named entity 'RIG-I' named entity 'THEIR' named entity 'DOMAIN' named entity 'TARGETED' named entity 'THESE' named entity 'STRUCTURAL' named entity 'RNA BINDING' named entity 'RIG-I' named entity 'ROLE' named entity 'OUR' named entity 'CARD' named entity 'PREVIOUS' named entity 'RNA' named entity 'NUCLEIC ACIDS' named entity 'ACTIVATION' named entity 'EDITED' named entity 'RECEPTORS' named entity 'INSIGHTS' named entity 'ISSUE' named entity 'PATHOGENS' named entity 'STEP' named entity 'CONTACTS' named entity 'REPRESSION' named entity 'RLR' named entity 'STUDIES' named entity 'VIRAL INFECTIONS' named entity 'HOST CELLS' named entity 'PROTEIN ' named entity 'TIME' named entity 'RELEASE' named entity 'COMPLEX' named entity 'CONTAINING' named entity 'CONFORMATION' named entity 'ROLES' named entity 'ACTIVATING' named entity 'INCOMPLETE' named entity 'REVIEW' named entity 'COMES' named entity 'ANTAGONISTS' named entity 'BASIS' named entity 'MDA5' named entity 'NON-SELF' named entity 'POTENTIAL' named entity 'C-TERMINAL' named entity 'NUMEROUS' named entity 'LIGHT' named entity 'NEW' named entity 'VIRAL PATHOGENESIS' named entity 'SIGNALING NETWORKS' named entity 'CONTROL' named entity 'MOLECULES' named entity 'RIG-I LIKE RECEPTORS' named entity 'ASSOCIATED' named entity 'SERIES' named entity 'IMMUNE' named entity 'REGULATORY' named entity 'IMPORTANT' named entity 'HELICASE' named entity 'KNOWLEDGE' named entity 'ACTIVATION' named entity 'MODULE' named entity 'MULTIPLE'

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