About: A simple and compact smartphone-based device for the quantitative readout of colloidal gold lateral flow immunoassay strips

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About: A simple and compact smartphone-based device for the quantitative readout of colloidal gold lateral flow immunoassay strips Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A simple and compact smartphone-based device for the quantitative readout of colloidal gold lateral flow immunoassay strips
Creator	Wang, Lei Xiao, Wei Xu, Fei Bian, Hongfen Fu, Qiangqiang Huang, Caihong Tang, Yong Xie, Kaixin Yan, Junjie
Source	Elsevier; Medline; PMC
abstract	Abstract Colloidal gold lateral flow immunoassay strips (AuNPs-LFIS) have been widely applied as qualitative diagnostic tools for point-of-care tests (POCT). If strip readers were incorporated, their use could be extended to quantitative analysis. However, their cost and non-portability render commercial strip readers unavailable for use in either home testing, community or rural hospital diagnosis. This is particularly true for on-site testing. Here, a smartphone-based reader was designed and 3D-printed for quantitatively assess AuNPs-LFIS. The basic principle of the devise was relying on a smartphone’s ambient light sensor (SPALS). This sensor was harnessed to measure the transmitted light intensities originating from the T-lines on the strips, the transmitted light intensities vary with concentration of AuNP on the T-lines. To validate this approach, our newly developed smartphone’s ambient light sensor-based reader (SPALS-reader) was used to readout AuNPs-LFIS of three analytical targets: cadmium ion (Cd2+; limit of detection (LOD) was 0.16 ng/mL), clenbuterol (CL; LOD was 0.046 ng/mL), and porcine epidemic diarrhea virus (PEDV; LOD was 0.055 μg/mL). The result showed good consistency with the results of conventional image analysis approaches, indicating that the smartphone-based device is appropriate for use in AuNPs-LFIS readouts. Compared with the traditional analysis method, the developed AuNPs-LFIS reader is easier operated, lower cost and more portable, which provided an on-site quantitative analysis tool for AuNPs-LFIS and enhances the applied range of AuNPs-LFIS.
has issue date	2018-08-01(xsd:dateTime)
bibo:doi	10.1016/j.snb.2018.03.110
bibo:pmid	32288251
has license	els-covid
sha1sum (hex)	987d2d5a1710526b45b365c59088e5dadca2e19f
schema:url	https://doi.org/10.1016/j.snb.2018.03.110
resource representing a document's title	A simple and compact smartphone-based device for the quantitative readout of colloidal gold lateral flow immunoassay strips
has PubMed Central identifier	PMC7127147
has PubMed identifier	32288251
schema:publication	Sensors and Actuators B: Chemical
resource representing a document's body	covid:987d2d5a1710526b45b365c59088e5dadca2e19f#body_text
is schema:about of	named entity 'COMPACT' named entity 'BASED' named entity 'strips' named entity 'immunoassay' named entity 'quantitatively' named entity 'qualitative' named entity 'rural' named entity 'The' named entity 'good' named entity 'testing' named entity 'lateral' named entity 'READOUT' named entity 'TESTING' named entity 'APPLIED' named entity 'PORTABLE' named entity 'COMMUNITY' named entity 'CADMIUM ION' named entity 'POINT-OF-CARE' named entity 'COMPARED' named entity 'SMARTPHONE' named entity 'SITE' named entity '27S' named entity 'DIAGNOSTIC' named entity 'BASIC' named entity 'LINES' named entity 'COLLOIDAL GOLD' named entity 'RURAL HOSPITAL' named entity 'HOME' named entity 'ANALYTICAL' named entity 'INDICATING' named entity 'STRIPS' named entity 'LIMIT OF DETECTION' named entity 'RENDER' named entity 'TOOL' named entity 'USED' named entity 'EITHER' named entity 'HERE' named entity 'QUANTITATIVE ANALYSIS' named entity 'CLENBUTEROL' named entity 'TARGETS' named entity 'PROVIDED' named entity 'TRUE' named entity 'AUNP' named entity 'APPROACH' named entity 'RESULT' named entity 'NEWLY' named entity 'READOUT' named entity 'CONCENTRATION OF' covid:arg/987d2d5a1710526b45b365c59088e5dadca2e19f named entity 'COLLOIDAL GOLD' named entity 'DEVICE' named entity 'PRINTED' named entity 'AMBIENT' named entity 'RANGE' named entity 'DIAGNOSIS' named entity 'HAVE' named entity 'READER' named entity 'DEVISE' named entity 'OUR' named entity 'EXTENDED' named entity 'LOWER' named entity 'APPROPRIATE' named entity 'TO MEASURE' named entity 'RESULTS' named entity 'COULD BE' named entity 'COMMERCIAL' named entity 'IMAGE ANALYSIS' named entity 'UNAVAILABLE' named entity 'SIMPLE' named entity 'READERS' named entity 'TOOLS' named entity 'DEVICE' named entity 'COST'

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