About: Genomic Characterization of a Newly Discovered Coronavirus Associated with Acute Respiratory Distress Syndrome in Humans

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About: Genomic Characterization of a Newly Discovered Coronavirus Associated with Acute Respiratory Distress Syndrome in Humans Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Genomic Characterization of a Newly Discovered Coronavirus Associated with Acute Respiratory Distress Syndrome in Humans
Creator	Fouchier, Ron Osterhaus, Albert Lauber, Chris Haagmans, Bart Bestebroer, Theo Gorbalenya, Alexander Snijder, Eric Buchmeier, Michael De Graaf, Miranda Stalin Raj, V Van Boheemen, Sander Zaki, Ali
Source	Medline; PMC
abstract	A novel human coronavirus (HCoV-EMC/2012) was isolated from a man with acute pneumonia and renal failure in June 2012. This report describes the complete genome sequence, genome organization, and expression strategy of HCoV-EMC/2012 and its relation with known coronaviruses. The genome contains 30,119 nucleotides and contains at least 10 predicted open reading frames, 9 of which are predicted to be expressed from a nested set of seven subgenomic mRNAs. Phylogenetic analysis of the replicase gene of coronaviruses with completely sequenced genomes showed that HCoV-EMC/2012 is most closely related to Tylonycteris bat coronavirus HKU4 (BtCoV-HKU4) and Pipistrellus bat coronavirus HKU5 (BtCoV-HKU5), which prototype two species in lineage C of the genus Betacoronavirus. In accordance with the guidelines of the International Committee on Taxonomy of Viruses, and in view of the 75% and 77% amino acid sequence identity in 7 conserved replicase domains with BtCoV-HKU4 and BtCoV-HKU5, respectively, we propose that HCoV-EMC/2012 prototypes a novel species in the genus Betacoronavirus. HCoV-EMC/2012 may be most closely related to a coronavirus detected in Pipistrellus pipistrellus in The Netherlands, but because only a short sequence from the most conserved part of the RNA-dependent RNA polymerase-encoding region of the genome was reported for this bat virus, its genetic distance from HCoV-EMC remains uncertain. HCoV-EMC/2012 is the sixth coronavirus known to infect humans and the first human virus within betacoronavirus lineage C.
has issue date	2012-11-20(xsd:dateTime)
bibo:doi	10.1128/mbio.00473-12
bibo:pmid	23170002
has license	cc-by-nc-sa
sha1sum (hex)	98513efd2f4e86626a263f1eb350ed2702ecb8ec
schema:url	https://doi.org/10.1128/mbio.00473-12
resource representing a document's title	Genomic Characterization of a Newly Discovered Coronavirus Associated with Acute Respiratory Distress Syndrome in Humans
has PubMed Central identifier	PMC3509437
has PubMed identifier	23170002
schema:publication	mBio
resource representing a document's body	covid:98513efd2f4e86626a263f1eb350ed2702ecb8ec#body_text
is schema:about of	named entity 'genome' named entity 'Betacoronavirus' named entity 'Pipistrellus' named entity 'Taxonomy' covid:arg/98513efd2f4e86626a263f1eb350ed2702ecb8ec named entity 'HCoV-EMC/2012' named entity 'detected' named entity 'acute' named entity 'open reading frames' named entity 'prototype' named entity 'Viruses' named entity 'replicase' named entity 'genome' named entity 'pneumonia' named entity 'coronavirus' named entity 'Acute Respiratory Distress Syndrome' named entity 'HCoV-EMC' named entity 'Pipistrellus bat coronavirus HKU5' named entity 'Betacoronavirus' named entity 'genus' named entity 'Tylonycteris bat coronavirus HKU4' named entity 'replicase' named entity 'human coronavirus' named entity 'replicase' named entity 'nested set' named entity 'genus' named entity 'International Committee on Taxonomy of Viruses' named entity 'human coronavirus' named entity 'GenBank' named entity 'protease' named entity 'AUG codon' named entity 'conserved domains' named entity 'supernatant' named entity 'coronaviruses' named entity 'cell culture' named entity 'enzymatic activities' named entity 'protein' named entity 'Sanger sequencing' named entity 'ORF' named entity 'SARS-CoV' named entity 'incubation' named entity 'protein' named entity 'ribosomal' named entity 'cell culture' named entity 'ICTV' named entity 'serum' named entity 'genome sequence' named entity 'sequence identities' named entity 'consensus sequence' named entity 'coronaviruses' named entity 'coronaviruses' named entity 'bat species' named entity 'original specimen' named entity 'HCoV-EMC/2012' named entity 'coronavirus' named entity 'virus' named entity 'reverse transcribed' named entity 'Applied Biosystems' named entity 'random hexamer' named entity 'viruses' named entity 'sequence variants' named entity 'genomes' named entity '454 sequencing' named entity 'ribosomal frameshifting' named entity 'nucleocapsid' named entity 'HCoV-EMC' named entity 'innate immune signaling' named entity 'betacoronaviruses' named entity 'genome sequence' named entity 'Saudi Arabia'

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