About: Randomized, Placebo Controlled Study of the Effect of Propentofylline on Survival Time and Quality of Life of Cats with Feline Infectious Peritonitis

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About: Randomized, Placebo Controlled Study of the Effect of Propentofylline on Survival Time and Quality of Life of Cats with Feline Infectious Peritonitis Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Randomized, Placebo Controlled Study of the Effect of Propentofylline on Survival Time and Quality of Life of Cats with Feline Infectious Peritonitis
Creator	Hartmann, K Weber, K Fischer, Y Ritz, S Sauter-Louis, C
Source	Medline; PMC
abstract	BACKGROUND: Currently there is no drug proven to effectively treat cats with feline infectious peritonitis (FIP). HYPOTHESIS: Propentofylline (PPF) can decrease vasculitis, and therefore prolong survival time in cats with FIP, and increase their quality of life. ANIMALS: Twenty‐three privately owned cats with FIP. METHODS: Placebo‐controlled double‐blind trial. FIP was confirmed by histology or immunostaining of feline coronavirus (FCoV) antigen in effusion or tissue macrophages or both. The cats were randomly selected for treatment with either PPF or placebo. All cats received additional treatment with glucocorticoids, antibiotics, and low molecular weight heparin according to methods. RESULTS: There was no statistically significant difference in the survival time of cats treated with PPF (8 days, 95% CI 5.4–10.6) versus placebo (7.5 days, 95% CI 4.4–9.6). The median survival time of all cats was 8 days (4–36 days). There was neither a difference in quality of life (day 7, P = .892), in the amount of effusion (day 7, P = .710), the tumor necrosis factor‐alpha (TNF‐α) concentration (day 7, P = .355), nor in any other variable investigated in this study, including a complete blood count, and a small animal biochemistry profile. CONCLUSIONS AND CLINICAL IMPORTANCE: This study did not detect an effect of PPF on the survival time, the quality of life, or any clinical or laboratory parameter in cats with FIP. Therefore, PPF does not appear to be an effective treatment option in cats with a late stage of the disease FIP.
has issue date	2011-10-12(xsd:dateTime)
bibo:doi	10.1111/j.1939-1676.2011.00806.x
bibo:pmid	22092616
has license	no-cc
sha1sum (hex)	9832e99b5e9cf68d174c2d2f53f87e1ba054c971
schema:url	https://doi.org/10.1111/j.1939-1676.2011.00806.x
resource representing a document's title	Randomized, Placebo Controlled Study of the Effect of Propentofylline on Survival Time and Quality of Life of Cats with Feline Infectious Peritonitis
has PubMed Central identifier	PMC7166892
has PubMed identifier	22092616
schema:publication	J Vet Intern Med
resource representing a document's body	covid:9832e99b5e9cf68d174c2d2f53f87e1ba054c971#body_text
is schema:about of	named entity 'Study' named entity 'THEIR' named entity 'FELINE INFECTIOUS PERITONITIS' named entity 'DECREASE' named entity 'INCREASE' named entity 'CATS' named entity 'BACKGROUND' named entity 'peritonitis' named entity 'proven' named entity 'cats' named entity 'Background' named entity 'Life' named entity 'feline infectious peritonitis' named entity 'Quality of Life' named entity 'Propentofylline' named entity 'statistically significant' named entity 'mode of action' named entity 'animal biochemistry' named entity 'RBC' named entity 'interferon' named entity 'statistically significant' named entity 'dexamethasone' named entity 'endothelial cell' named entity 'alanine aminotransferase' named entity 'chemical structure' named entity 'confounding factor' named entity 'WBC' named entity 'CBC' named entity 'thoraco' named entity '8 days' named entity 'animal welfare' named entity 'immunosuppressive' named entity 'white blood cells' named entity 'PPF' named entity 'SPSS' named entity 'survival time' named entity 'CBC' named entity 'serum' named entity 'Glucocorticoids' named entity 'vasculitis' named entity 'immunofluorescent' named entity 'proinflammatory cytokines' named entity 'TNF-a' named entity 'antibody' named entity 'antibody' named entity 'well-being' named entity 'anecdotal reports' named entity 'immune-mediated' named entity 'randomly assigned' named entity 'interleukin 1' named entity 'PPF' named entity 'immunofluorescent' named entity 'LMU University of Munich' named entity 'TNF-a' named entity 'PPF' named entity 'incubation' named entity 'histopathological examination' named entity 'survival time' named entity 'cellulose' named entity 'Karnofsky' named entity 'correlation' named entity 'creatinine' named entity 'significance level' named entity 'inoculation' named entity 'geriatric' named entity 'Trental' named entity 'ultrasound' named entity 'PPF' named entity '7.5' named entity 'Persian' named entity 'antibodies' named entity 'paracentesis' named entity 'FIV' named entity 'PPF' named entity 'FeLV' named entity '21 days' named entity 'measured values'

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