About: RANTES, Macrophage-Inhibitory Protein 1α, and the Eosinophil Product Major Basic Protein Are Released into Upper Respiratory Secretions during Virus-Induced Asthma Exacerbations in Children

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About: RANTES, Macrophage-Inhibitory Protein 1α, and the Eosinophil Product Major Basic Protein Are Released into Upper Respiratory Secretions during Virus-Induced Asthma Exacerbations in Children Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	RANTES, Macrophage-Inhibitory Protein 1α, and the Eosinophil Product Major Basic Protein Are Released into Upper Respiratory Secretions during Virus-Induced Asthma Exacerbations in Children
Creator	Johnston, Sebastian Papi, Alberto Compton, Steven Gleich, Gerald Low, J Seminario, Maria Shute, Janis Teran, Luis
Source	Medline; PMC
abstract	The presence of cytokines and the toxic eosinophil granule product major basic protein (MBP) was investigated in nasal aspirates from children with naturally occurring virus-induced asthma exacerbations and compared with levels in nasal aspirates taken from the same children when asymptomatic. Increased levels of MBP accompanied by increased levels of the chemokines RANTES and macrophage-inhibitory protein 1α were observed in nasal aspirates from children during the virus-induced exacerbations. Granulocyte-macrophage colony-stimulating factor was mostly undetectable in samples obtained during both symptomatic and asymptomatic periods. Interleukin-5 levels were low, but tended to increase in samples from symptomatic children. These data confirm that the eosinophil product MBP and the eosinophil chemoattractant chemokines RANTES and macrophage-inhibitory protein 1α are increased in upper respiratory viral infections associated with asthma exacerbations and suggest an important role for these chemokines in regulating eosinophil influx and activation. These chemokines may represent targets for therapeutic intervention in virus-induced asthma exacerbations.
has issue date	1999-03-01(xsd:dateTime)
bibo:doi	10.1086/314618
bibo:pmid	9952375
has license	no-cc
sha1sum (hex)	97f8e0c05e9324c35640b3d7217bdf63809414a8
schema:url	https://doi.org/10.1086/314618
resource representing a document's title	RANTES, Macrophage-Inhibitory Protein 1α, and the Eosinophil Product Major Basic Protein Are Released into Upper Respiratory Secretions during Virus-Induced Asthma Exacerbations in Children
has PubMed Central identifier	PMC7110233
has PubMed identifier	9952375
schema:publication	J Infect Dis
resource representing a document's body	covid:97f8e0c05e9324c35640b3d7217bdf63809414a8#body_text
is schema:about of	named entity 'EOSINOPHIL' named entity 'product' named entity 'targets' named entity 'nasal' named entity 'MACROPHAGE' named entity 'PRODUCT' named entity 'CHEMOKINES' named entity 'ASPIRATES' named entity 'ACTIVATION' named entity 'INHIBITORY' named entity 'THESE' named entity 'OBTAINED' named entity 'THERAPEUTIC INTERVENTION' named entity 'TARGETS' named entity 'NATURALLY OCCURRING' named entity 'UPPER' named entity 'BUT' named entity 'ASTHMA EXACERBATIONS' named entity 'BASIC PROTEIN' named entity 'LOW' named entity 'MAJOR' named entity 'CHILDREN' named entity 'MBP' named entity 'RANTES' named entity 'VIRUS' named entity 'CHILDREN' named entity 'PRODUCT' named entity 'PROTEIN ' named entity 'RESPIRATORY' named entity 'RELEASED' named entity 'SECRETIONS' named entity 'NASAL' named entity 'COMPARED' named entity 'ASTHMA EXACERBATIONS' named entity 'GRANULE PRODUCT' named entity 'TO INCREASE' named entity 'CONFIRM' named entity 'UPPER' named entity 'CYTOKINES' named entity 'PROTEIN ' named entity 'UNDETECTABLE' named entity '5 LEVELS' named entity 'CHEMOATTRACTANT' named entity 'SUGGEST' named entity 'GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR' named entity 'TAKEN' named entity 'INCREASED' named entity 'DATA' named entity 'INHIBITORY' named entity 'INDUCED' named entity 'IMPORTANT' named entity 'SYMPTOMATIC' named entity 'TOXIC' named entity 'MAJOR' named entity 'PERIODS' named entity 'RANTES' named entity 'ASYMPTOMATIC' named entity 'REGULATING' named entity 'ROLE' named entity 'SAMPLES' named entity 'REPRESENT' named entity 'RESPIRATORY' named entity 'INDUCED' named entity 'MACROPHAGE' named entity 'PRESENCE OF' named entity 'BASIC PROTEIN' named entity 'VIRUS' named entity 'VIRAL INFECTIONS' named entity 'INVESTIGATED' named entity 'EOSINOPHIL' named entity 'OBSERVED' named entity 'INTERLEUKIN-5 ' named entity 'LEVELS' named entity 'ASSOCIATED WITH'

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