About: Asthma, Viruses, and Nitric Oxide

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Asthma, Viruses, and Nitric Oxide Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Asthma, Viruses, and Nitric Oxide
Creator	Sanders, Scherer
source	Medline; PMC
abstract	Over the last two decades there has been a worldwide increase in the morbidity and mortality associated with asthma, a chronic inflammatory disease of the airways. There is a growing body of evidence that suggests there is an association between upper respiratory viral infections, particularly rhinovirus infections, and asthma exacerbations. Virally induced airways hyperreactivity has been associated with elevated numbers of inflammatory cells in the bronchial mucosa. Upon virus infection, respiratory epithelial cells produce proinflammatory cytokines, including IL‐6, IL‐8, RANTES, and GM‐CSF, which could contribute to the increased inflammatory cell recruitment noted in the airways. Whether or not a viral infection triggers an asthma attack may depend upon many factors, including the types of inflammatory cells recruited to the airways, the viral load, and variations in the host antiviral response. There is evidence to support the idea that eosinophils from asthmatic and symptomatic atopic subjects may be primed to respond to chemotactic cytokines produced by infected epithelial cells. Rhinovirus infections may therefore enhance airway eosinophilia in asthmatics, leading to airway hyperresponsiveness and impaired pulmonary function. Nitric oxide is a potent inhibitor of both rhinovirus‐induced cytokine production and viral replication and may play an important role in the host response to viral infections. Based upon these observations, we speculate that nitric oxide donors may represent a novel therapeutic approach for the treatment of rhinovirus infections and viral exacerbations of asthma.
has issue date	2003-11-03(xsd:dateTime)
bibo:doi	10.1046/j.1525-1373.1999.d01-19.x
bibo:pmid	10193439
has license	no-cc
sha1sum (hex)	97a00a0c464b11f33148ffba3f2c23a765d5dfba
schema:url	https://doi.org/10.1046/j.1525-1373.1999.d01-19.x
resource representing a document's title	Asthma, Viruses, and Nitric Oxide
has PubMed Central identifier	PMC7167740
has PubMed identifier	10193439
schema:publication	Proc Soc Exp Biol Med
resource representing a document's body	covid:97a00a0c464b11f33148ffba3f2c23a765d5dfba#body_text
is schema:about of	named entity 'airways' named entity 'inflammatory cells' named entity 'Nitric oxide' named entity 'worldwide' named entity 'potent' named entity 'recruitment' named entity 'viral infection' named entity 'decades' named entity 'cytokine' named entity 'Viruses' named entity 'asthmatic' named entity 'speculate' named entity 'attack' named entity 'chronic' named entity 'viral replication' named entity 'infected' named entity 'cytokines' named entity 'epithelial cells' named entity 'Rhinovirus' named entity 'chemotactic' named entity 'virus infection' named entity 'inflammatory cells' named entity 'asthmatic' named entity 'asthma exacerbations' named entity 'atopic' named entity 'IL-6' named entity 'cytokine' named entity 'respiratory viral infections' named entity 'protein synthesis' named entity 'proinflammatory' named entity 'respiratory epithelial' named entity 'cytokine' named entity 'asthmatic' named entity 'rhinovirus' named entity 'polyprotein' named entity 'medical costs' named entity 'viral protein' named entity 'polyprotein' named entity 'IL-6' named entity 'viral load' named entity 'adhesion molecule' named entity 'symptom' named entity 'physiological processes' named entity 'nasal lavage' named entity 'Virus' named entity 'bronchospasm' named entity 'viruses' named entity 'bronchoalveolar lavage' named entity 'NONOate' named entity 'bronchoalveolar lavage' named entity 'viral infections' named entity 'human rhinovirus' named entity 'ICAM-1' named entity 'chemoattractants' named entity 'asthma' named entity 'immunohistochemical' named entity 'viral infection' named entity 'protein' named entity 'pathogenesis' named entity 'mediated response' named entity 'cytokine' named entity 'proinflammatory' named entity 'nitric oxide' named entity 'viral load' named entity 'GM-CSF' named entity 'transcriptional regulation' named entity 'picornavirus' named entity 'vasodilator' named entity 'eotaxin' named entity 'rhinovirus' named entity 'coat proteins' named entity 'asymptomatic' named entity 'rhinovirus' named entity 'TH2' named entity 'epithelial cells' named entity 'iNOS' named entity 'cytokine' named entity 'asthma' named entity 'cytokine' named entity 'viral infections' named entity 'asthmatic individuals'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software