About: Molecular Mimicry between Chikungunya Virus and Host Components: A Possible Mechanism for the Arthritic Manifestations

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About: Molecular Mimicry between Chikungunya Virus and Host Components: A Possible Mechanism for the Arthritic Manifestations Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Molecular Mimicry between Chikungunya Virus and Host Components: A Possible Mechanism for the Arthritic Manifestations
Creator	Desai, Anita Reddy, Vijayalakshmi Vasanthapuram, Ravi Susarla Krishna, Shankar
topic	covid:977007f901c5697f613ad1b475532ebaf7baef86#this
source	PMC
abstract	BACKGROUND: Chikungunya virus (CHIKV), a reemerging pathogen causes a self limited illness characterized by fever, headache, myalgia and arthralgia. However, 10–20% affected individuals develop persistent arthralgia which contributes to considerable morbidity. The exact molecular mechanisms underlying these manifestations are not well understood. The present study investigated the possible occurrence of molecular mimicry between CHIKV E1 glycoprotein and host human components. METHODOLOGY: Bioinformatic tools were used to identify peptides of CHIKV E1 exhibiting similarity to host components. Two peptides (A&B) were identified using several bioinformatic tools, synthesised and used to validate the results obtained in silico. An ELISA was designed to assess the immunoreactivity of serum samples from CHIKV patients to these peptides. Further, experiments were conducted in a C57BL/6J experimental mouse model to investigate if peptide A and peptide B were indeed capable of inducing pathology. FINDINGS: The serum samples showed reactivity of varying degrees, indicating that these peptides are indeed being recognized by the host immune system during CHIKV infection. Further, these peptides when injected into C57BL/6J mice were able to induce significant inflammation in the muscles of C57BL/6J mice, similar to that observed in animals that were injected with CHIKV alone. Additionally, animals that were primed initially with CHIKV followed by a subsequent injection of the CHIKV peptides exhibited enhanced inflammatory pathology in the skeletal muscles as compared to animals that were injected with peptides or virus alone. Collectively these observations validate the hypothesis that molecular mimicry between CHIKV E1 protein and host proteins does contribute to pathology in CHIKV infection.
has issue date	2017-01-26(xsd:dateTime)
bibo:doi	10.1371/journal.pntd.0005238
bibo:pmid	28125580
has license	cc-by
sha1sum (hex)	977007f901c5697f613ad1b475532ebaf7baef86
schema:url	https://doi.org/10.1371/journal.pntd.0005238
resource representing a document's title	Molecular Mimicry between Chikungunya Virus and Host Components: A Possible Mechanism for the Arthritic Manifestations
has PubMed Central identifier	PMC5268390
has PubMed identifier	28125580
schema:publication	PLoS Negl Trop Dis
resource representing a document's body	covid:977007f901c5697f613ad1b475532ebaf7baef86#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/977007f901c5697f613ad1b475532ebaf7baef86
is schema:about of	named entity 'investigated' named entity 'Arthritic' covid:arg/977007f901c5697f613ad1b475532ebaf7baef86 named entity 'individuals' named entity 'arthralgia' named entity 'CHIKV' named entity 'morbidity' named entity 'host' named entity 'pathogen' named entity 'myalgia' named entity 'limited' named entity 'myalgia' named entity 'molecular mechanisms' named entity 'CHIKV' named entity 'precipitate' named entity 'beta arrestin' named entity 'peptide' named entity 'CHIKV' named entity 'tap water' named entity 'serum samples' named entity 'basophilia' named entity 'molecular mimicry' named entity 'CHIKV' named entity 'animal models' named entity 'stem cell' named entity 'hyperplasia' named entity 'homology' named entity 'CHIKV' named entity 'CHIKV' named entity 'structural homology' named entity 'w/v' named entity 'molecular mimicry' named entity 'Peptide' named entity 'CHIKV' named entity 'autoimmune' named entity 'alcohol' named entity 'Alphaviruses' named entity 'Ross River Virus' named entity 'pathology' named entity 'HLA-B27' named entity 'protein' named entity 'Peptide' named entity 'non-specific' named entity 'muscle' named entity 'real time PCR' named entity 'arthritic' named entity 'Chikungunya' named entity 'glycoprotein' named entity 'CHIKV' named entity 'CHIKV' named entity 'adjuvant' named entity 'India' named entity 'glycoprotein' named entity 'arthralgia' named entity 'Antibodies' named entity 'multiple sequence alignment' named entity 'Peptide' named entity 'amino acids' named entity 'homologous regions' named entity 'amino acid sequences' named entity 'protein' named entity 'Bioinformatics' named entity 'clinical diagnosis' named entity 'virus' named entity 'virus strain' named entity 'peptides' named entity 'autoimmune' named entity 'EMEM' named entity 'mice' named entity 'pathogenesis' named entity 'hydrophilicity' named entity 'CHIKV' named entity 'glycoprotein' named entity 'fluid volume' named entity 'peptides' named entity 'articular cartilage'

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