About: Chloroquine use improves dengue-related symptoms

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About: Chloroquine use improves dengue-related symptoms Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Chloroquine use improves dengue-related symptoms
Creator	Borges, Marcos Castro, Antonio Lopes Da Fonseca, Luiza, Antunes
Source	Medline; PMC
abstract	Dengue is the most important arboviral disease in the world. As chloroquine, an antimalarial agent, has shown some antiviral effects, this study evaluated its effect in patients with dengue. A randomised, double-blind study was performed by administering chloroquine or placebo for three days to 129 patients with dengue-related symptoms. Of these patients, 37 were confirmed as having dengue and completed the study; in total, 19 dengue patients received chloroquine and 18 received placebo. There was no significant difference in the duration of the disease or the degree and days of fever. However, 12 patients (63%) with confirmed dengue reported a substantial decrease in pain intensity and a great improvement in their ability to perform daily activities (p = 0.0004) while on the medication and the symptoms returned immediately after these patients stopped taking the medication. The same effect was not observed in patients with diseases other than dengue. Therefore, this study shows that patients with dengue treated with chloroquine had an improvement in their quality of life and were able to resume their daily activities. However, as chloroquine did not alter the duration of the disease or the intensity and days of fever, further studies are necessary to confirm the clinical effects and to assess the side effects of chloroquine in dengue patients.
has issue date	2013-08-01(xsd:dateTime)
bibo:doi	10.1590/0074-0276108052013010
bibo:pmid	23903975
has license	cc-by-nc
sha1sum (hex)	974de2ddd9575e32633a8038613f4e8f4333a70f
schema:url	https://doi.org/10.1590/0074-0276108052013010
resource representing a document's title	Chloroquine use improves dengue-related symptoms
has PubMed Central identifier	PMC3970591
has PubMed identifier	23903975
schema:publication	Mem Inst Oswaldo Cruz
resource representing a document's body	covid:974de2ddd9575e32633a8038613f4e8f4333a70f#body_text
is schema:about of	named entity 'SYMPTOMS' named entity 'RECEIVED' named entity 'ITS' named entity 'RESUME' named entity 'STUDIES' named entity 'ANTIVIRAL' named entity 'THEIR' named entity 'TOTAL' named entity 'COMPLETED' named entity 'RELATED' named entity 'DOUBLE-BLIND STUDY' named entity 'ANTIMALARIAL AGENT' named entity 'SIDE EFFECTS' named entity 'DENGUE' named entity 'WORLD' named entity 'RETURNED' named entity 'PERFORM' named entity 'DURATION' named entity 'REPORTED' named entity 'However' named entity 'symptoms' named entity 'chloroquine' named entity 'DAYS' named entity 'OTHER THAN' named entity 'DAILY ACTIVITIES' named entity 'PLACEBO' named entity 'DID' named entity 'THESE' named entity 'DISEASES' named entity 'SIGNIFICANT' named entity 'ADMINISTERING' named entity '129' named entity 'DENGUE' named entity 'USE' named entity 'CHLOROQUINE' named entity 'RELATED' named entity 'DISEASE' named entity 'SYMPTOMS' named entity 'CONFIRMED' named entity 'FEVER' named entity 'ASSESS' named entity 'TAKING' named entity 'STOPPED' named entity 'NECESSARY' named entity 'TREATED WITH' named entity 'DIFFERENCE' named entity 'EFFECT' named entity 'NOT OBSERVED' named entity 'CLINICAL EFFECTS' named entity '28P' named entity 'IMPROVES' named entity 'ALTER' named entity 'QUALITY OF LIFE' named entity 'MEDICATION' named entity 'IMMEDIATELY' named entity 'EVALUATED' named entity 'PERFORMED BY' named entity 'PATIENTS' named entity 'GREAT' named entity 'DECREASE' named entity 'STUDY' named entity 'INTENSITY' named entity 'EFFECTS' named entity 'IMPORTANT' named entity 'CONFIRM' named entity 'IMPROVEMENT' named entity 'DEGREE' named entity 'PAIN INTENSITY' named entity 'CHLOROQUINE' named entity 'ARBOVIRAL DISEASE' covid:arg/974de2ddd9575e32633a8038613f4e8f4333a70f named entity 'symptoms' named entity 'returned' named entity 'disease' named entity 'fever' named entity 'side effects' named entity 'received' named entity 'dengue'

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