About: Gut microbiota may underlie the predisposition of healthy individuals to COVID-19

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Gut microbiota may underlie the predisposition of healthy individuals to COVID-19
Creator	Wang, Jun Chen, Hao Xu, Shen, Bo Cai, Xue Guo, Tiannan Fu, Wu, Xiaomai Zhu, Yi Zhao, Haihong Yi, Chen, Geng-Dong Chen, Yu -Ming Gou, Wanglong Jiang, Zengliang Ling, Wenhua Miao, Zelei Shuai, Menglei Xiao, Congmei Xiao, Mian-Li Yue, Zheng, Ju-Sheng
source	MedRxiv
abstract	The COVID-19 pandemic is spreading globally with high disparity in the susceptibility of the disease severity. Identification of the key underlying factors for this disparity is highly warranted. Here we describe constructing a proteomic risk score based on 20 blood proteomic biomarkers which predict the progression to severe COVID-19. We demonstrate that in our own cohort of 990 individuals without infection, this proteomic risk score is positively associated with proinflammatory cytokines mainly among older, but not younger, individuals. We further discovered that a core set of gut microbiota could accurately predict the above proteomic biomarkers among 301 individuals using a machine learning model, and that these gut microbiota features are highly correlated with proinflammatory cytokines in another set of 366 individuals. Fecal metabolomic analysis suggested potential amino acid-related pathways linking gut microbiota to inflammation. This study suggests that gut microbiota may underlie the predisposition of normal individuals to severe COVID-19.
has issue date	2020-04-25(xsd:dateTime)
bibo:doi	10.1101/2020.04.22.20076091
has license	medrxiv
sha1sum (hex)	9718eeee44736c9aa9a129ee616c8a001ac56bec
schema:url	https://doi.org/10.1101/2020.04.22.20076091
resource representing a document's title	Gut microbiota may underlie the predisposition of healthy individuals to COVID-19
resource representing a document's body	covid:9718eeee44736c9aa9a129ee616c8a001ac56bec#body_text
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