About: Clinical characteristics and viral load of respiratory syncytial virus and human metapneumovirus in children hospitaled for acute lower respiratory tract infection

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About: Clinical characteristics and viral load of respiratory syncytial virus and human metapneumovirus in children hospitaled for acute lower respiratory tract infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical characteristics and viral load of respiratory syncytial virus and human metapneumovirus in children hospitaled for acute lower respiratory tract infection
Creator	Duan, Zhao-Jun Gao, Han-Chun Xie, Zhi-Ping Li, Yu-Mei Li, Yu-Ning Liu, Li-Jun Tang, Yi-Jie Yan, Xiao-Li Yang, Xue-Mei
Source	Medline; PMC
abstract	Respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) are two common viral pathogens in acute lower respiratory tract infections (ALRTI). However, the association of viral load with clinical characteristics is not well‐defined in ALRTI. To explore the correlation between viral load and clinical characteristics of RSV and HMPV in children hospitalized for ALRTI in Lanzhou, China. Three hundred and eighty‐seven children hospitalized for ALRTI were enrolled. Nasopharyngeal aspirates (NPAs) were sampled from each children. Real‐time PCR was used to screen RSV, HMPV, and twelve additional respiratory viruses. Bronchiolitis was the leading diagnoses both in RSV and HMPV positive patients. A significantly greater frequency of wheezing (52% vs. 33.52%, P = 0.000) was noted in RSV positive and negative patients. The RSV viral load was significant higher in children aged <1 year (P = 0.003), children without fever and wheezing (P = 0.015 and P = 0.000), days of illness <14 days (P = 0.002), children with bronchiolitis (P = 0.012) and children with RSV single infections (P = 0.000). No difference was found in the clinical features of HMPV positive and negative patients. The HMPV viral load had no correlation with any clinical characteristics. The incidences of severe disease were similar between single infection and coinfection for the two viruses (RSV, P = 0.221; HMPV, P = 0.764) and there has no statistical significance between severity and viral load (P = 0.166 and P = 0.721). Bronchiolitis is the most common disease caused by RSV and HMPV. High viral load or co‐infection may be associated with some symptoms but neither has a significant impact on disease severity for the two viruses. J. Med. Virol. 89:589–597, 2017. © 2016 Wiley Periodicals, Inc.
has issue date	2016-09-28(xsd:dateTime)
bibo:doi	10.1002/jmv.24687
bibo:pmid	27632796
has license	no-cc
sha1sum (hex)	9714e44a38f476b5b3393e7f4d89585344c63f54
schema:url	https://doi.org/10.1002/jmv.24687
resource representing a document's title	Clinical characteristics and viral load of respiratory syncytial virus and human metapneumovirus in children hospitaled for acute lower respiratory tract infection
has PubMed Central identifier	PMC7166468
has PubMed identifier	27632796
schema:publication	J Med Virol
resource representing a document's body	covid:9714e44a38f476b5b3393e7f4d89585344c63f54#body_text
is schema:about of	named entity 'disease' named entity 'aspirates' named entity 'Bronchiolitis' named entity 'negative' named entity 'Respiratory' named entity 'RSV' named entity 'leading' named entity 'impact' named entity 'severe' named entity 'days' named entity 'RSV' named entity 'RSV' named entity 'HMPV' named entity 'RSV' named entity 'viruses' named entity 'viral load' named entity 'HMPV' named entity 'RSV' named entity 'RSV' named entity 'clinical characteristics' named entity 'HMPV' named entity 'Nasopharyngeal' named entity 'viral pathogens' named entity 'coinfection' named entity 'viruses' named entity 'RSV' named entity 'clinical characteristics' named entity 'HMPV' named entity 'Viral Load' named entity 'Respiratory Syncytial Virus' named entity 'viral load' named entity 'gene' named entity 'multiple linear regression' named entity 'correlation' named entity 'RSV' named entity 'innate immune' named entity 'co-infected' named entity 'HMPV' named entity 'viral pathogen' named entity 'chronic illness' named entity 'RSV' named entity 'Fisher's exact test' named entity 'RNA transcripts' named entity 'bronchiolitis' named entity 'pneumonia' named entity 'Italy' named entity '3.4 million' named entity 'bronchiolitis' named entity 'Statistical analysis' named entity 'HMPV' named entity 'HMPV' named entity 'HMPV' named entity 'HMPV' named entity 'correlation' named entity 'viral infections' named entity 'virus' named entity 'Applied Biosystems' named entity 'viral RNA' named entity 'RSV' named entity 'HMPV' named entity 'tachypnea' named entity 'bronchitis' named entity 'Chongqing' named entity 'wheezing' named entity 'virus' named entity 'viral load' named entity 'interferon' named entity 'bronchitis' named entity 'correlation' named entity 'childhood diseases' named entity 'viral load' named entity 'RSV' named entity 'cyanosis'

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