About: An Overview of Current Approaches Toward the Treatment and Prevention of West Nile Virus Infection

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About: An Overview of Current Approaches Toward the Treatment and Prevention of West Nile Virus Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	An Overview of Current Approaches Toward the Treatment and Prevention of West Nile Virus Infection
Creator	Acharya, Dhiraj Bai, Fengwei
topic	covid:96fa7b0201a495e59794b2b1c2e8cd794d1ba413#this
Source	Medline; PMC
abstract	The persistence of West Nile virus (WNV) infections throughout the USA since its inception in 1999 and its continuous spread throughout the globe calls for an urgent need of effective treatments and prevention measures. Although the licensing of several WNV vaccines for veterinary use provides a proof of concept, similar efforts on the development of an effective vaccine for humans remain still unsuccessful. Increased understanding of biology and pathogenesis of WNV together with recent technological advancements have raised hope that an effective WNV vaccine may be available in the near future. In addition, rapid progress in the structural and functional characterization of WNV and other flaviviral proteins have provided a solid base for the design and development of several classes of inhibitors as potential WNV therapeutics. Moreover, the therapeutic monoclonal antibodies demonstrate an excellent efficacy against WNV in animal models and represent a promising class of WNV therapeutics. However, there are some challenges as to the design and development of a safe and efficient WNV vaccine or therapeutic. In this chapter, we discuss the current approaches, progress, and challenges toward the development of WNV vaccines, therapeutic antibodies, and antiviral drugs.
has issue date	2016-05-18(xsd:dateTime)
bibo:doi	10.1007/978-1-4939-3670-0_19
bibo:pmid	27188563
has license	no-cc
sha1sum (hex)	96fa7b0201a495e59794b2b1c2e8cd794d1ba413
schema:url	https://doi.org/10.1007/978-1-4939-3670-0_19
resource representing a document's title	An Overview of Current Approaches Toward the Treatment and Prevention of West Nile Virus Infection
has PubMed Central identifier	PMC7120145
has PubMed identifier	27188563
schema:publication	West Nile Virus
resource representing a document's body	covid:96fa7b0201a495e59794b2b1c2e8cd794d1ba413#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/96fa7b0201a495e59794b2b1c2e8cd794d1ba413
is schema:about of	named entity 'TREATMENT' named entity 'development' named entity 'USA' named entity 'effective' named entity 'WNV' named entity 'functional' named entity 'PREVENTION OF' named entity 'OVERVIEW' named entity 'SIMILAR' named entity 'HAVE' named entity 'DEVELOPMENT' named entity 'INFECTIONS' named entity 'WEST NILE VIRUS INFECTION' named entity 'POTENTIAL' named entity 'VETERINARY' named entity 'ITS' named entity 'NEAR' named entity 'MONOCLONAL ANTIBODIES' named entity 'AVAILABLE' named entity 'TREATMENTS' named entity 'PERSISTENCE' named entity 'CHARACTERIZATION' named entity 'SPREAD' named entity 'UNSUCCESSFUL' named entity 'RAISED' named entity 'HOPE' named entity 'CURRENT' named entity 'CLASSES' named entity 'ADDITION' named entity 'NEED' named entity 'EFFECTIVE' named entity 'VACCINES' named entity 'GLOBE' named entity 'CURRENT' named entity 'THERAPEUTICS' named entity 'SAFE' named entity 'HUMANS' named entity 'CHAPTER' named entity 'RAPID' named entity 'CONTINUOUS' named entity 'REPRESENT' named entity 'USE' named entity 'CLASS' named entity 'PREVENTION MEASURES' named entity 'VACCINE' named entity 'FUNCTIONAL' named entity 'DESIGN' named entity 'THERAPEUTIC' named entity 'BIOLOGY' named entity 'ANTIVIRAL DRUGS' named entity 'ANIMAL MODELS ' named entity 'USA' named entity 'FUTURE' named entity 'PROOF OF CONCEPT' named entity 'LICENSING' named entity 'CACY' named entity 'RECENT' named entity 'THERAPEUTIC ANTIBODIES' named entity 'PROGRESS' named entity 'WNV' named entity 'EXCELLENT' named entity 'URGENT' named entity 'APPROACHES' named entity 'SOLID BASE' named entity 'INHIBITORS' named entity 'PATHOGENESIS' named entity 'CHALLENGES' named entity 'INCREASED' named entity 'WEST NILE VIRUS' named entity 'MAY BE' named entity 'PROTEINS' named entity 'UNDERSTANDING' named entity 'PROVIDES' named entity 'STRUCTURAL' named entity 'PROVIDED' named entity 'DISCUSS' named entity 'APPROACHES' named entity 'hope'

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