About: Broad neutralizing activity of a human monoclonal antibody against H7N9 strains from 2013 to 2017

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Broad neutralizing activity of a human monoclonal antibody against H7N9 strains from 2013 to 2017 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Broad neutralizing activity of a human monoclonal antibody against H7N9 strains from 2013 to 2017
Creator	Xiao, Yan Jin, Qi Chen, Cong Liu, Liguo Liu, Zuliang Wang, Jianmin
Source	Medline; PMC
abstract	H7N9 influenza virus has been circulating among humans for five epidemic waves since it was first isolated in 2013 in China. The recent increase in H7N9 infections during the fifth outbreak in China has caused concerns of a possible pandemic. In this study, we describe a previously characterized human monoclonal antibody, HNIgGA6, obtained by isolating rearranged heavy-chain and light-chain genes from patients who had recovered from H7N9 infections. HNIgGA6 recognized multiple HAs and neutralized the infectivity of 11 out of the 12 H7N9 strains tested, as well as three emerging HPAI H7N9 isolates. The only resistant strain was A/Shanghai/1/2013 (H7N9-SH1), which carries the avian receptor alleles 186V and 226Q in the sialic acid-binding pocket. The mAb broadly neutralized divergent H7N9 strains from 2013 to 2017 and represents a potential alternative treatment for H7N9 interventions.
has issue date	2018-11-14(xsd:dateTime)
bibo:doi	10.1038/s41426-018-0182-2
bibo:pmid	30425238
has license	cc-by
sha1sum (hex)	9697849eeaed7f72a196d9ca4d4d8cfad6a8031e
schema:url	https://doi.org/10.1038/s41426-018-0182-2
resource representing a document's title	Broad neutralizing activity of a human monoclonal antibody against H7N9 strains from 2013 to 2017
has PubMed Central identifier	PMC6234208
has PubMed identifier	30425238
schema:publication	Emerg Microbes Infect
resource representing a document's body	covid:9697849eeaed7f72a196d9ca4d4d8cfad6a8031e#body_text
is schema:about of	named entity 'ACTIVITY' named entity 'H7N9' named entity 'infections' named entity 'multiple' named entity 'H7N9' named entity 'neutralized' named entity 'alternative' named entity 'STRAINS' named entity 'PANDEMIC' named entity 'BINDING' named entity 'GENES' named entity 'RESISTANT' named entity 'STRAIN' named entity 'POTENTIAL' named entity 'ISOLATED' named entity 'RECEPTOR' named entity 'HUMAN' named entity 'MONOCLONAL ANTIBODY' named entity 'TREATMENT' named entity '2F1' named entity 'INFECTIVITY' named entity 'HPAI' named entity 'MULTIPLE' named entity 'MONOCLONAL ANTIBODY' named entity 'BROAD' named entity 'HUMAN' named entity 'CARRIES' named entity 'CHINA' named entity 'H7N9' named entity 'AVIAN' named entity 'INFECTIONS' named entity 'POSSIBLE' named entity 'PREVIOUSLY' named entity 'RECOVERED' named entity 'EPIDEMIC' named entity 'LIGHT-CHAIN' named entity 'MAB' named entity 'ISOLATING' named entity 'FIFTH' named entity 'OBTAINED BY' named entity 'CAUSED' named entity 'WAVES' named entity 'DESCRIBE' named entity 'HUMANS' named entity 'SIALIC ACID' named entity 'ALLELES' named entity 'OUTBREAK' named entity 'INTERVENTIONS' named entity 'CIRCULATING' named entity 'INFLUENZA VIRUS' named entity 'INCREASE' named entity 'TESTED' named entity 'HEAVY-CHAIN' named entity 'H7N9 INFLUENZA' named entity 'PATIENTS' named entity 'SH1' named entity 'STRAINS' named entity 'CONCERNS' named entity 'ALTERNATIVE' named entity 'REARRANGED' named entity 'STUDY' named entity 'CHARACTERIZED' named entity 'RECENT' named entity 'WAS A' covid:arg/9697849eeaed7f72a196d9ca4d4d8cfad6a8031e named entity 'monoclonal antibody' named entity 'divergent' named entity 'describe' named entity '2013' named entity 'heavy-chain' named entity 'strain' named entity 'strains' named entity 'outbreak in China' named entity 'H7N9' named entity 'HPAI' named entity 'human monoclonal antibody'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software